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Informing and Validating Translational Mechanism‐Based Models for Antibiotics by Experimental and Computational Approaches

Clinical pharmacology and therapeutics, 2021-12, Vol.110 (6), p.1426-1428

Bulitta, Jürgen B.

2021

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Distinguishing Antimicrobial Models with Different Resistance Mechanisms via Population Pharmacodynamic Modeling

PLoS computational biology, 2016-03, Vol.12 (3), p.e1004782-e1004782

2016

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Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans

Antimicrobial agents and chemotherapy, 2019-05, Vol.63 (5)

2019

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Population pharmacokinetic rationale for intravenous contezolid acefosamil followed by oral contezolid dosage regimens

Antimicrobial agents and chemotherapy, 2024-04, Vol.68 (4), p.e0140023

2024

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Development of a Physiologically Relevant Population Pharmacokinetic in Vitro–in Vivo Correlation Approach for Designing Extended-Release Oral Dosage Formulation

Molecular pharmaceutics, 2017-01, Vol.14 (1), p.53-65

2017

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Aminoglycoside-resistance gene signatures are predictive of aminoglycoside MICs for carbapenem-resistant Klebsiella pneumoniae

Journal of antimicrobial chemotherapy, 2022-02, Vol.77 (2), p.356-363

2022

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Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection model

Journal of antimicrobial chemotherapy, 2020-09, Vol.75 (9), p.2622-2632

2020

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Resurgence of Colistin: A Review of Resistance, Toxicity, Pharmacodynamics, and Dosing

Pharmacotherapy, 2010-12, Vol.30 (12), p.1279-1291

2010

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Central and peripheral lung deposition of fluticasone propionate dry powder inhaler formulations in humans characterized by population pharmacokinetics

Pharmaceutical research, 2023-05, Vol.40 (5), p.1177-1191

2023

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Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling

Antimicrobial agents and chemotherapy, 2017-12, Vol.61 (12)

2017

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Penetration of Antibacterials into Bone: Pharmacokinetic, Pharmacodynamic and Bioanalytical Considerations

Clinical pharmacokinetics, 2009-01, Vol.48 (2), p.89-124

2009

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Penicillin-Binding Protein 5/6 Acting as a Decoy Target in Pseudomonas aeruginosa Identified by Whole-Cell Receptor Binding and Quantitative Systems Pharmacology

Antimicrobial agents and chemotherapy, 2023-06, Vol.67 (6), p.e0160322-e0160322

2023

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High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model

Antimicrobial agents and chemotherapy, 2017-03, Vol.61 (3)

2017

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Controlling antibiotic release from mesoporous silica nano drug carriers via self-assembled polyelectrolyte coating

Journal of materials science. Materials in medicine, 2015-02, Vol.26 (2), p.117-7, Article 117

2015

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Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics

Antimicrobial agents and chemotherapy, 2024-02, Vol.68 (2), p.e0139323

2024

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Evaluation of Pharmacokinetic/Pharmacodynamic Model-Based Optimized Combination Regimens against Multidrug-Resistant Pseudomonas aeruginosa in a Murine Thigh Infection Model by Using Humanized Dosing Schemes

Antimicrobial agents and chemotherapy, 2017-12, Vol.61 (12)

2017

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Population pharmacokinetics of enrofloxacin and florfenicol in the giant danio (Devario aequipinnatus) following oral administration of both antibiotics and bath administration of enrofloxacin

Aquaculture, 2024-01, Vol.579, p.740222, Article 740222

2024

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Mechanistic Insights to Combating NDM- and CTX-M-Coproducing Klebsiella pneumoniae by Targeting Cell Wall Synthesis and Outer Membrane Integrity

Antimicrobial agents and chemotherapy, 2022-09, Vol.66 (9), p.e0052722

2022

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Population pharmacokinetics and humanized dosage regimens matching the peak, area, trough, and range of amikacin plasma concentrations in immune-competent murine bloodstream and lung infection models

Antimicrobial agents and chemotherapy, 2024-03, Vol.68 (3), p.e0139423

2024

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Clinical Population Pharmacokinetics and Toxicodynamics of Linezolid

Antimicrobial agents and chemotherapy, 2014-04, Vol.58 (4), p.2334-2343

2014

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Distinguishing inducible and non-inducible resistance to colistin in Pseudomonas aeruginosa by Quantitative and Systems Pharmacology modeling at low and standard inocula

Journal of pharmaceutical sciences, 2024-01, Vol.113 (1), p.202-213

2024

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Individual Components of Polymyxin B Modeled via Population Pharmacokinetics to Design Humanized Dosage Regimens for a Bloodstream and Lung Infection Model in Immune-Competent Mice

Antimicrobial agents and chemotherapy, 2023-05, Vol.67 (5), p.e0019723

2023

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Characterization of Hypermutator Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis in Australia

Antimicrobial agents and chemotherapy, 2019-04, Vol.63 (4)

2019

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Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii

Antimicrobial agents and chemotherapy, 2016-07, Vol.60 (7), p.3913-3920

2016

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Aminoglycosides against carbapenem-resistant Enterobacteriaceae in the critically ill: the pitfalls of aminoglycoside susceptibility

Expert review of anti-infective therapy, 2017-06, Vol.15 (6), p.519-526

2017

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Informing and Validating Translational Mechanism‐Based Models for Antibiotics by Experimental and Computational Approaches

Distinguishing Antimicrobial Models with Different Resistance Mechanisms via Population Pharmacodynamic Modeling

Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans

Population pharmacokinetic rationale for intravenous contezolid acefosamil followed by oral contezolid dosage regimens

Development of a Physiologically Relevant Population Pharmacokinetic in Vitro–in Vivo Correlation Approach for Designing Extended-Release Oral Dosage Formulation

Aminoglycoside-resistance gene signatures are predictive of aminoglycoside MICs for carbapenem-resistant Klebsiella pneumoniae

Determining the optimal dosing of a novel combination regimen of ceftazidime/avibactam with aztreonam against NDM-1-producing Enterobacteriaceae using a hollow-fibre infection model

Resurgence of Colistin: A Review of Resistance, Toxicity, Pharmacodynamics, and Dosing

Central and peripheral lung deposition of fluticasone propionate dry powder inhaler formulations in humans characterized by population pharmacokinetics

Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling

Penetration of Antibacterials into Bone: Pharmacokinetic, Pharmacodynamic and Bioanalytical Considerations

Penicillin-Binding Protein 5/6 Acting as a Decoy Target in Pseudomonas aeruginosa Identified by Whole-Cell Receptor Binding and Quantitative Systems Pharmacology

High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model

Controlling antibiotic release from mesoporous silica nano drug carriers via self-assembled polyelectrolyte coating

Improved characterization of aminoglycoside penetration into human lung epithelial lining fluid via population pharmacokinetics

Evaluation of Pharmacokinetic/Pharmacodynamic Model-Based Optimized Combination Regimens against Multidrug-Resistant Pseudomonas aeruginosa in a Murine Thigh Infection Model by Using Humanized Dosing Schemes

Population pharmacokinetics of enrofloxacin and florfenicol in the giant danio (Devario aequipinnatus) following oral administration of both antibiotics and bath administration of enrofloxacin

Mechanistic Insights to Combating NDM- and CTX-M-Coproducing Klebsiella pneumoniae by Targeting Cell Wall Synthesis and Outer Membrane Integrity

Population pharmacokinetics and humanized dosage regimens matching the peak, area, trough, and range of amikacin plasma concentrations in immune-competent murine bloodstream and lung infection models

Clinical Population Pharmacokinetics and Toxicodynamics of Linezolid

Distinguishing inducible and non-inducible resistance to colistin in Pseudomonas aeruginosa by Quantitative and Systems Pharmacology modeling at low and standard inocula

Individual Components of Polymyxin B Modeled via Population Pharmacokinetics to Design Humanized Dosage Regimens for a Bloodstream and Lung Infection Model in Immune-Competent Mice

Characterization of Hypermutator Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis in Australia

Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii

Aminoglycosides against carbapenem-resistant Enterobacteriaceae in the critically ill: the pitfalls of aminoglycoside susceptibility

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