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Cloning, Characterization and Site-Directed Mutagenesis of Canine Renin

Journal of biochemistry (Tokyo), 2007-12, Vol.142 (6), p.671-680

2007

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Purification and characterization of recombinant human renin for X-ray crystallization studies

BMC biochemistry, 2008-06, Vol.9 (1), p.19-19

2008

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In Vitro and In Vivo Assessment of the Potential of Supersaturation to Enhance the Absorption of Poorly Soluble Basic Drugs

Journal of pharmaceutical innovation, 2020-12, Vol.15 (4), p.591-602

2020

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Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists

Bioorganic & medicinal chemistry, 2016-03, Vol.24 (6), p.1384-1391

2016

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Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist

Journal of medicinal chemistry, 2016-04, Vol.59 (7), p.3264-3271

2016

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Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors

Molecular pharmacology, 2012-10, Vol.82 (4), p.719-727

2012

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The potent, selective RORγt blocker, VTP-43742, suppresses Th17 production in vivo and provides greater benefit than IL-17 blockade in the EAE model of autoimmunity (THER3P.968)

The Journal of immunology (1950), 2015-05, Vol.194 (1_Supplement), p.68-68.1

2015

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Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor

Bioorganic & medicinal chemistry, 2017-07, Vol.25 (14), p.3649-3657

2017

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Safety, tolerability, pharmacokinetics and pharmacodynamics of VTP-43742, a RORγt inhibitor, in normal healthy volunteers

The Journal of immunology (1950), 2016-05, Vol.196 (1_Supplement), p.71-71.4

2016

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P4‐217: EFFECTS OF BACE1 INHIBITION ON ABETA IN RATS AND TG2576

Alzheimer's & dementia, 2014-07, Vol.10 (4S_Part_23), p.P867-P867

2014

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EFFECTS OF BACE1 INHIBITION ON ABETA IN RATS AND TG2576

Alzheimer's & dementia, 2014-07, Vol.10 (4), p.P867-P867

2014

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Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists

Bioorganic & medicinal chemistry, 2016-03, Vol.24 (6)

2016

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Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (20), p.5044-5050

2016

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Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1

Journal of medicinal chemistry, 2011-09, Vol.54 (17), p.6050-6062

2011

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VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945)

The Journal of immunology (1950), 2015-05, Vol.194 (1_Supplement), p.208-208.5|68.3

2015

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Photoreactive Analogues of Prenyl Diphosphates as Inhibitors and Probes of Human Protein Farnesyltransferase and Geranylgeranyltransferase Type I

The Journal of biological chemistry, 1995-08, Vol.270 (32), p.19035-19040

1995

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Pharmacological characterization of the new bace1 inhibitor bi 1181181

Alzheimer's & dementia, 2015-07, Vol.11 (7), p.P477-P477

2015

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P1‐314: Pharmacological characterization of the new bace1 inhibitor bi 1181181

Alzheimer's & dementia, 2015-07, Vol.11 (7S_Part_10), p.P477-P477

2015

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Identification of inhibitors of bacterial transcription/translation machinery utilizing a miniaturized 1536-well format screen

Journal of biomolecular screening, 2001-08, Vol.6 (4), p.233-243

2001

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Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility

ACS medicinal chemistry letters, 2011-10, Vol.2 (10), p.747-751

2011

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Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.881-886

2010

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A novel LXR beta-selective partial agonist increases the ApoE-ABCA1 pathway and decreases hippocampal BETA-AMYLOID in cynomolgus monkeys without increasing liver triglycerides

Alzheimer's & dementia, 2013, Vol.8 (4), p.S752-S753

2013

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Optimization of orally bioavailable alkyl amine renin inhibitors

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.694-699

2010

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P4‐268: A novel LXR beta‐selective partial agonist increases the ApoE‐ABCA1 pathway and decreases hippocampal BETA‐AMYLOID in cynomolgus monkeys without increasing liver triglycerides

Alzheimer's & dementia, 2012-07, Vol.8 (4S_Part_20), p.S752-S753

2012

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Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (16), p.4836-4843

2011

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Cloning, Characterization and Site-Directed Mutagenesis of Canine Renin

Purification and characterization of recombinant human renin for X-ray crystallization studies

In Vitro and In Vivo Assessment of the Potential of Supersaturation to Enhance the Absorption of Poorly Soluble Basic Drugs

Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists

Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist

Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors

The potent, selective RORγt blocker, VTP-43742, suppresses Th17 production in vivo and provides greater benefit than IL-17 blockade in the EAE model of autoimmunity (THER3P.968)

Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor

Safety, tolerability, pharmacokinetics and pharmacodynamics of VTP-43742, a RORγt inhibitor, in normal healthy volunteers

P4‐217: EFFECTS OF BACE1 INHIBITION ON ABETA IN RATS AND TG2576

EFFECTS OF BACE1 INHIBITION ON ABETA IN RATS AND TG2576

Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists

Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core

Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1

VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945)

Photoreactive Analogues of Prenyl Diphosphates as Inhibitors and Probes of Human Protein Farnesyltransferase and Geranylgeranyltransferase Type I

Pharmacological characterization of the new bace1 inhibitor bi 1181181

P1‐314: Pharmacological characterization of the new bace1 inhibitor bi 1181181

Identification of inhibitors of bacterial transcription/translation machinery utilizing a miniaturized 1536-well format screen

Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility

Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design

A novel LXR beta-selective partial agonist increases the ApoE-ABCA1 pathway and decreases hippocampal BETA-AMYLOID in cynomolgus monkeys without increasing liver triglycerides

Optimization of orally bioavailable alkyl amine renin inhibitors

P4‐268: A novel LXR beta‐selective partial agonist increases the ApoE‐ABCA1 pathway and decreases hippocampal BETA‐AMYLOID in cynomolgus monkeys without increasing liver triglycerides

Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket

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