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Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children

Clinical pharmacology and therapeutics, 2018-07, Vol.104 (1), p.188-200

2018

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Development of physiologically based pharmacokinetic model to evaluate the relative systemic exposure to quetiapine after administration of IR and XR formulations to adults, children and adolescents

Biopharmaceutics & drug disposition, 2014-09, Vol.35 (6), p.341-352

2014

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The right compound in the right assay at the right time: an integrated discovery DMPK strategy

Drug metabolism reviews, 2012-08, Vol.44 (3), p.224-252

2012

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Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study

Neuropsychopharmacology (New York, N.Y.), 2017-03, Vol.42 (4), p.844-853

2017

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Population pharmacokinetics of naloxegol in a population of 1247 healthy subjects and patients

British journal of clinical pharmacology, 2016-01, Vol.81 (1), p.89-100

2016

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Population pharmacokinetic modeling of quetiapine after administration of seroquel and seroquel XR formulations to Western and Chinese patients with schizophrenia, schizoaffective disorder, or bipolar disorder

Journal of clinical pharmacology, 2015-11, Vol.55 (11), p.1248-1255

2015

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Effect of multiple intravenous doses of lanicemine (AZD6765) on the pharmacokinetics of midazolam in healthy subjects

Journal of clinical pharmacology, 2015-09, Vol.55 (9), p.1024-1030

2015

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Pharmacokinetics, metabolism and excretion of [14C]-lanicemine (AZD6765), a novel low-trapping N-methyl-d-aspartic acid receptor channel blocker, in healthy subjects

Xenobiotica, 2015-03, Vol.45 (3), p.244-255

2015

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Physiologically based pharmacokinetic modeling to predict complex drug-drug interactions: a case study of AZD2327 and its metabolite, competitive and time-dependent CYP3A inhibitors

Biopharmaceutics & drug disposition, 2015-11, Vol.36 (8), p.507-519

2015

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Population Exposure‐Response Modeling Supported Selection of Naloxegol Doses in Phase III Studies in Patients With Opioid‐Induced Constipation

CPT: pharmacometrics and systems pharmacology, 2017-10, Vol.6 (10), p.705-711

2017

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In vitro and in vivo metabolism of a selective δ-opioid receptor

Drug metabolism and disposition, 2011-10, Vol.39 (10), p.1883

2011

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4-Piperidin-4-ylidenemethyl-benzamides as δ-opioid receptor agonists for CNS indications: Identifying clinical candidates

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1174-1178

2012

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Multiparameter exploration of piperazine derivatives as δ-opioid receptor agonists for CNS indications

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1169-1173

2012

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Combining radio telemetry and automated blood sampling: A novel approach for integrative pharmacology and toxicology studies

Journal of pharmacological and toxicological methods, 2010-07, Vol.62 (1), p.30-39

2010

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Liquid chromatographic separation of diastereomers and structural isomers on cyclodextrin-bonded phases

Analytical chemistry (Washington), 1985-01, Vol.57 (1), p.234-237

1985

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Theory of homopolymer fractionation and its application to gradient elution liquid chromatography

Macromolecules, 1983-05, Vol.16 (3), p.466-476

1983

Volltextzugriff (PDF)

Theory of homopolymer retention in semidilute solutions using liquid chromatography

Macromolecules, 1984-05, Vol.17 (3), p.400-407

1984

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Use of pseudophase TLC in teaching laboratories

Journal of chemical education, 1984-05, Vol.61 (5), p.457

1984

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Determination of zafirlukast, a selective leukotriene antagonist, human plasma by normal-phase high-performance liquid chromatography with fluorescence detection

Journal of chromatography. B, Biomedical sciences and applications, 1997-08, Vol.696 (1), p.131-136

1997

Volltextzugriff (PDF)

Determination of ZD9583, a thromboxane receptor antagonist, in human plasma and urine by liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry

Journal of chromatography. B, Biomedical sciences and applications, 1997-08, Vol.695 (2), p.299-307

1997

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Evaluation of the theory and experimental consequences of gradient liquid chromatographic polymer separations

Journal of Chromatography A, 1984, Vol.288 (1), p.15-24

1984

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Direct Serum Injection and Analysis of Drugs with Aqueous Mobile Phases Containing Triethylammonium Acetate

Journal of liquid chromatography, 1989-04, Vol.12 (5), p.861-873

1989

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A Comparison of Polymer Separation Efficiency and Resolution by Gradient LC, GPC and TLC

Journal of liquid chromatography, 1984-01, Vol.7 (1), p.29-43

1984

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Practice, Mechanism and Theory of Reversed Phase TLC Polymer Fractionation

Journal of liquid chromatography, 1983-01, Vol.6 (1), p.1-22

1983

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Current application of algae derivatives for bioplastic production: A review

Bioresource technology, 2022-03, Vol.347, p.126698-126698, Article 126698

2022

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Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children

Development of physiologically based pharmacokinetic model to evaluate the relative systemic exposure to quetiapine after administration of IR and XR formulations to adults, children and adolescents

The right compound in the right assay at the right time: an integrated discovery DMPK strategy

Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study

Population pharmacokinetics of naloxegol in a population of 1247 healthy subjects and patients

Population pharmacokinetic modeling of quetiapine after administration of seroquel and seroquel XR formulations to Western and Chinese patients with schizophrenia, schizoaffective disorder, or bipolar disorder

Effect of multiple intravenous doses of lanicemine (AZD6765) on the pharmacokinetics of midazolam in healthy subjects

Pharmacokinetics, metabolism and excretion of [14C]-lanicemine (AZD6765), a novel low-trapping N-methyl-d-aspartic acid receptor channel blocker, in healthy subjects

Physiologically based pharmacokinetic modeling to predict complex drug-drug interactions: a case study of AZD2327 and its metabolite, competitive and time-dependent CYP3A inhibitors

Population Exposure‐Response Modeling Supported Selection of Naloxegol Doses in Phase III Studies in Patients With Opioid‐Induced Constipation

In vitro and in vivo metabolism of a selective δ-opioid receptor

4-Piperidin-4-ylidenemethyl-benzamides as δ-opioid receptor agonists for CNS indications: Identifying clinical candidates

Multiparameter exploration of piperazine derivatives as δ-opioid receptor agonists for CNS indications

Combining radio telemetry and automated blood sampling: A novel approach for integrative pharmacology and toxicology studies

Liquid chromatographic separation of diastereomers and structural isomers on cyclodextrin-bonded phases

Theory of homopolymer fractionation and its application to gradient elution liquid chromatography

Theory of homopolymer retention in semidilute solutions using liquid chromatography

Use of pseudophase TLC in teaching laboratories

Determination of zafirlukast, a selective leukotriene antagonist, human plasma by normal-phase high-performance liquid chromatography with fluorescence detection

Determination of ZD9583, a thromboxane receptor antagonist, in human plasma and urine by liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry

Evaluation of the theory and experimental consequences of gradient liquid chromatographic polymer separations

Direct Serum Injection and Analysis of Drugs with Aqueous Mobile Phases Containing Triethylammonium Acetate

A Comparison of Polymer Separation Efficiency and Resolution by Gradient LC, GPC and TLC

Practice, Mechanism and Theory of Reversed Phase TLC Polymer Fractionation

Current application of algae derivatives for bioplastic production: A review

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