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Concordance of preclinical and clinical pharmacology and toxicology of monoclonal antibodies and fusion proteins: soluble targets

British journal of pharmacology, 2012-06, Vol.166 (3), p.806-822

2012

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Concordance of preclinical and clinical pharmacology and toxicology of therapeutic monoclonal antibodies and fusion proteins: cell surface targets

British journal of pharmacology, 2012-06, Vol.166 (3), p.823-846

2012

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Characterization of golimumab, a human monoclonal antibody specific for human tumor necrosis factor α

mAbs, 2010-07, Vol.2 (4), p.428-439

2010

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Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice

Respiratory research, 2009-06, Vol.10 (1), p.43-43, Article 43

2009

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Anti‐interleukin‐6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus

Immunology, 2006-11, Vol.119 (3), p.296-305

2006

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Critical Review of Preclinical Approaches to Evaluate the Potential of Immunosuppressive Drugs to Influence Human Neoplasia

International Journal of Toxicology, 2010-09, Vol.29 (5), p.435-466

2010

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Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys

Journal of allergy and clinical immunology, 2001-08, Vol.108 (2), p.250-257

2001

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Therapeutic dosing with anti-interleukin-13 monoclonal antibody inhibits asthma progression in mice

The Journal of pharmacology and experimental therapeutics, 2005-04, Vol.313 (1), p.8

2005

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Genetic aspects of immune-mediated adverse drug effects

Nature reviews. Drug discovery, 2005-01, Vol.4 (1), p.59-69

Bugelski, Peter J

2005

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CNTO 530 increases expression of HbA and HbF in murine models of β-thalassemia and sickle cell anemia

Current pharmaceutical biotechnology, 2013-02, Vol.14 (2), p.242

2013

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Monoclonal antibody-induced cytokine-release syndrome

Expert review of clinical immunology, 2009-09, Vol.5 (5), p.499-521

2009

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CNTO 530 functions as a potent EPO mimetic via unique sustained effects on bone marrow proerythroblast pools

Blood, 2009-05, Vol.113 (20), p.4955-4962

2009

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Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model

Transplantation, 2007-08, Vol.84 (3), p.308

2007

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Immunomodulatory Effects of Anti-CD4 Antibody in Host Resistance against Infections and Tumors in Human CD4 Transgenic Mice

Infection and Immunity, 2001-02, Vol.69 (2), p.1032-1043

2001

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Development of a human whole blood assay for prediction of cytokine release similar to anti-CD28 superagonists using multiplex cytokine and hierarchical cluster analysis

International immunopharmacology, 2011-11, Vol.11 (11), p.1697-1705

2011

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Immunotoxicologic effects of cyclosporine on tumor progression in models of squamous cell carcinoma and B-cell lymphoma in C3H mice

Journal of immunotoxicology, 2012-01, Vol.9 (1), p.43-55

2012

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Effects of CNTO 530, an erythropoietin mimetic-IgG4 fusion protein, on embryofetal development in rats and rabbits

Birth defects research. Part B. Developmental and reproductive toxicology, 2010-04, Vol.89 (2), p.87-96

2010

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Development of a murine model of lymph node metastases suitable for immunotoxicity studies

Journal of pharmacological and toxicological methods, 2011-05, Vol.63 (3), p.236-249

2011

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Pharmacodynamics of Recombinant Human Erythropoietin in Murine Bone Marrow

Pharmaceutical research, 2008-02, Vol.25 (2), p.369-378

2008

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A Novel Technique For Mapping the Lipid Composition of Atherosclerotic Fatty Streaks by En Face Fluorescence Microscopy

The journal of histochemistry and cytochemistry, 1997-05, Vol.45 (5), p.743-753

1997

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A statistical pattern recognition approach for determining cellular viability and lineage phenotype in cultured cells and murine bone marrow

Cytometry. Part A, 2007-08, Vol.71A (8), p.612-624

2007

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T-Dependent Antigen Response (TDAR) Tests: Meta-Analysis of Results Generated Across Multiple Laboratories

Journal of immunotoxicology, 2007-04, Vol.4 (2), p.159-164

2007

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B cells and beyond: therapeutic opportunities targeting inflammation

Inflammation & allergy drug targets, 2007-09, Vol.6 (3), p.142

2007

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Sequential univariate gating approach to study the effects of erythropoietin in murine bone marrow

Cytometry. Part A, 2008-08, Vol.73A (8), p.702-714

2008

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Myelodysplasia and anemia of chronic disease in human tumor necrosis factor-α transgenic mice

Cytometry. Part A, 2008-02, Vol.73A (2), p.148-159

2008

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Concordance of preclinical and clinical pharmacology and toxicology of monoclonal antibodies and fusion proteins: soluble targets

Concordance of preclinical and clinical pharmacology and toxicology of therapeutic monoclonal antibodies and fusion proteins: cell surface targets

Characterization of golimumab, a human monoclonal antibody specific for human tumor necrosis factor α

Long-term activation of TLR3 by poly(I:C) induces inflammation and impairs lung function in mice

Anti‐interleukin‐6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus

Critical Review of Preclinical Approaches to Evaluate the Potential of Immunosuppressive Drugs to Influence Human Neoplasia

Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys

Therapeutic dosing with anti-interleukin-13 monoclonal antibody inhibits asthma progression in mice

Genetic aspects of immune-mediated adverse drug effects

CNTO 530 increases expression of HbA and HbF in murine models of β-thalassemia and sickle cell anemia

Monoclonal antibody-induced cytokine-release syndrome

CNTO 530 functions as a potent EPO mimetic via unique sustained effects on bone marrow proerythroblast pools

Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model

Immunomodulatory Effects of Anti-CD4 Antibody in Host Resistance against Infections and Tumors in Human CD4 Transgenic Mice

Development of a human whole blood assay for prediction of cytokine release similar to anti-CD28 superagonists using multiplex cytokine and hierarchical cluster analysis

Immunotoxicologic effects of cyclosporine on tumor progression in models of squamous cell carcinoma and B-cell lymphoma in C3H mice

Effects of CNTO 530, an erythropoietin mimetic-IgG4 fusion protein, on embryofetal development in rats and rabbits

Development of a murine model of lymph node metastases suitable for immunotoxicity studies

Pharmacodynamics of Recombinant Human Erythropoietin in Murine Bone Marrow

A Novel Technique For Mapping the Lipid Composition of Atherosclerotic Fatty Streaks by En Face Fluorescence Microscopy

A statistical pattern recognition approach for determining cellular viability and lineage phenotype in cultured cells and murine bone marrow

T-Dependent Antigen Response (TDAR) Tests: Meta-Analysis of Results Generated Across Multiple Laboratories

B cells and beyond: therapeutic opportunities targeting inflammation

Sequential univariate gating approach to study the effects of erythropoietin in murine bone marrow

Myelodysplasia and anemia of chronic disease in human tumor necrosis factor-α transgenic mice

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