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1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 2): action in other targets and antitargets

Current medicinal chemistry, 2012-09, Vol.19 (25), p.4306-4323

2012

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1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 1): action in ion channels and GPCRs

Current medicinal chemistry, 2011-11, Vol.18 (32), p.4901-4922

2011

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Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents

Phytochemistry (Oxford), 2020-02, Vol.170, p.112222-112222, Article 112222

2020

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Ligands of diltiazem binding site: an overview of some chemotypes

Mini reviews in medicinal chemistry, 2009-10, Vol.9 (12), p.1379-1388

2009

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Cardiovascular Profile of Xanthone-Based 1,4 Dihydropyridines Bearing a Lidoflazine Pharmacophore Fragment

Molecules (Basel, Switzerland), 2018-11, Vol.23 (12), p.3088

2018

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Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra‐amines

British journal of pharmacology, 2001-03, Vol.132 (5), p.1009-1016

2001

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L-Type Calcium Channel Blockers: From Diltiazem to 1,2,4-Oxadiazol-5-ones via Thiazinooxadiazol-3-one Derivatives

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2352-2362

2009

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Discovery of Novel and Cardioselective Diltiazem-like Calcium Channel Blockers via Virtual Screening

Journal of medicinal chemistry, 2008-09, Vol.51 (18), p.5552-5565

2008

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Coumarin 1,4-Dihydropyridine Derivatives

Bioorganic & medicinal chemistry, 1998-06, Vol.6 (6), p.803-810

1998

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Novel Quinolizidinyl Derivatives as Antiarrhythmic Agents

Journal of medicinal chemistry, 2007-01, Vol.50 (2), p.334-343

2007

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1,4-Dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety

Bioorganic & medicinal chemistry, 2005-05, Vol.13 (10), p.3423-3430

2005

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A New Class of Selective Myocardial Calcium Channel Modulators. 2. Role of the Acetal Chain in Oxadiazol-3-one Derivatives

Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2445-2456

2005

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In vitro characterization of tripitramine, a polymethylene tetraamine displaying high selectivity and affinity for muscarinic M2 receptors

British journal of pharmacology, 1995-04, Vol.114 (7), p.1507-1517

1995

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Evaluation of muscarinic M3-receptor antagonism of Solenostemma argel leaves

Planta medica, 2010, Vol.76 (12)

2010

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Cardiovascular Characterization of [1,4]Thiazino[3,4-c][1,2,4]oxadiazol-1-one Derivatives: Selective Myocardial Calcium Channel Modulators

Journal of medicinal chemistry, 2002-08, Vol.45 (16), p.3475-3481

2002

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Multidrug reverting activity toward leukemia cells in a group of new verapamil analogues with low cardiovascular activity

Leukemia research, 2006, Vol.30 (1), p.1-8

2006

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1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine

Bioorganic & medicinal chemistry, 1996-10, Vol.4 (10), p.1629-1635

1996

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Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone for Potential Use against Alzheimer's Disease

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4186-4189

1998

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Design, Synthesis, and in Vitro Activity of Catamphiphilic Reverters of Multidrug Resistance: Discovery of a Selective, Highly Efficacious Chemosensitizer with Potency in the Nanomolar Range

Journal of medicinal chemistry, 1999-05, Vol.42 (10), p.1687-1697

1999

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Synthesis and pharmacological evaluation of verapamil analogs with restricted molecular flexibility

European journal of medicinal chemistry, 1994, Vol.29 (2), p.139-148

1994

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Design, Synthesis, and Biological Evaluation of Symmetrically and Unsymmetrically Substituted Methoctramine-Related Polyamines as Muscular Nicotinic Receptor Noncompetitive Antagonists

Journal of medicinal chemistry, 1999-12, Vol.42 (25), p.5212-5223

1999

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Synthesis and “in vitro” cardiovascular activity of 4-aryl-2,3,3a,4-tetrahydro-1h-pyrrolo[2,1-c][1,4]benzothiazin-1-ones and 7-acetoxy-6-phenyl-7a,8,9,10-tetrahydropyrrolo [2,1,-d][1,5]benzothiazepin-10-one

Bioorganic & medicinal chemistry letters, 1994-05, Vol.4 (10), p.1235-1240

1994

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Structure–activity relationships and optimisation of the selective MDR modulator 2-(3,4-dimethoxyphenyl)-5-(9-fluorenylamino)-2-(methylethyl) pentanenitrile and its N-methyl derivative

Bioorganic & medicinal chemistry, 2001-10, Vol.9 (10), p.2673-2682

2001

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Structure−Activity Relationships of Methoctramine-Related Polyamines as Muscular Nicotinic Receptor Noncompetitive Antagonists. 2. Role of Polymethylene Chain Lengths Separating Amine Functions and of Substituents on the Terminal Nitrogen Atoms

Journal of medicinal chemistry, 2002-04, Vol.45 (9), p.1860-1878

2002

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Design, Synthesis, and Biological Activity of Prazosin-Related Antagonists. Role of the Piperazine and Furan Units of Prazosin on the Selectivity for α1-Adrenoreceptor Subtypes

Journal of medicinal chemistry, 1998-11, Vol.41 (24), p.4844-4853

1998

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1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 2): action in other targets and antitargets

1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 1): action in ion channels and GPCRs

Antihypertensive phytocomplexes of proven efficacy and well-established use: Mode of action and individual characterization of the active constituents

Ligands of diltiazem binding site: an overview of some chemotypes

Cardiovascular Profile of Xanthone-Based 1,4 Dihydropyridines Bearing a Lidoflazine Pharmacophore Fragment

Analysis of the muscarinic receptor subtype mediating inhibition of the neurogenic contractions in rabbit isolated vas deferens by a series of polymethylene tetra‐amines

L-Type Calcium Channel Blockers: From Diltiazem to 1,2,4-Oxadiazol-5-ones via Thiazinooxadiazol-3-one Derivatives

Discovery of Novel and Cardioselective Diltiazem-like Calcium Channel Blockers via Virtual Screening

Coumarin 1,4-Dihydropyridine Derivatives

Novel Quinolizidinyl Derivatives as Antiarrhythmic Agents

1,4-Dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety

A New Class of Selective Myocardial Calcium Channel Modulators. 2. Role of the Acetal Chain in Oxadiazol-3-one Derivatives

In vitro characterization of tripitramine, a polymethylene tetraamine displaying high selectivity and affinity for muscarinic M2 receptors

Evaluation of muscarinic M3-receptor antagonism of Solenostemma argel leaves

Cardiovascular Characterization of [1,4]Thiazino[3,4-c][1,2,4]oxadiazol-1-one Derivatives: Selective Myocardial Calcium Channel Modulators

Multidrug reverting activity toward leukemia cells in a group of new verapamil analogues with low cardiovascular activity

1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine

Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone for Potential Use against Alzheimer's Disease

Design, Synthesis, and in Vitro Activity of Catamphiphilic Reverters of Multidrug Resistance: Discovery of a Selective, Highly Efficacious Chemosensitizer with Potency in the Nanomolar Range

Synthesis and pharmacological evaluation of verapamil analogs with restricted molecular flexibility

Design, Synthesis, and Biological Evaluation of Symmetrically and Unsymmetrically Substituted Methoctramine-Related Polyamines as Muscular Nicotinic Receptor Noncompetitive Antagonists

Synthesis and “in vitro” cardiovascular activity of 4-aryl-2,3,3a,4-tetrahydro-1h-pyrrolo[2,1-c][1,4]benzothiazin-1-ones and 7-acetoxy-6-phenyl-7a,8,9,10-tetrahydropyrrolo [2,1,-d][1,5]benzothiazepin-10-one

Structure–activity relationships and optimisation of the selective MDR modulator 2-(3,4-dimethoxyphenyl)-5-(9-fluorenylamino)-2-(methylethyl) pentanenitrile and its N-methyl derivative

Structure−Activity Relationships of Methoctramine-Related Polyamines as Muscular Nicotinic Receptor Noncompetitive Antagonists. 2. Role of Polymethylene Chain Lengths Separating Amine Functions and of Substituents on the Terminal Nitrogen Atoms

Design, Synthesis, and Biological Activity of Prazosin-Related Antagonists. Role of the Piperazine and Furan Units of Prazosin on the Selectivity for α1-Adrenoreceptor Subtypes

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