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Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors

Bioorganic & medicinal chemistry letters, 1998-08, Vol.8 (16), p.2235-2240

1998

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Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor Xa inhibitors

Bioorganic & medicinal chemistry letters, 1998-07, Vol.8 (14), p.1877-1882

1998

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Synthesis and Tissue Biodistribution of [.omega.-11C]Palmitic Acid. A Novel Pet Imaging Agent for Cardiac Fatty acid Metabolism

Journal of medicinal chemistry, 1994-07, Vol.37 (15), p.2481-2485

1994

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Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1

The Journal of biological chemistry, 2005-05, Vol.280 (20), p.19867-19874

2005

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A62 LUNG FIBROSIS: FIBROBLAST BIOLOGY: Identification Of Novel Small-Molecule Loxl2 Inhibitors By High Throughput Screening

American journal of respiratory and critical care medicine, 2014-01, Vol.189, p.1

2014

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A62 LUNG FIBROSIS: FIBROBLAST BIOLOGY: Impact Of Lpa And Lpa1 Receptor Antagonists On Gene And Protein Expression In Human Primary Cells

American journal of respiratory and critical care medicine, 2014-01, Vol.189, p.1

2014

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A62 LUNG FIBROSIS: FIBROBLAST BIOLOGY: Small-Molecule And Peptide Activators Of The Nrf2-Dependent Antioxidant Response Element

American journal of respiratory and critical care medicine, 2014-01, Vol.189, p.1

2014

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Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin

Acta crystallographica. Section D, Biological crystallography., 1999-08, Vol.55 (8), p.1395-1404

1999

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C58 EMERGING TECHNIQUES AND NEW TOOLS TO UNDERSTAND LUNG DISEASES: Phenotypic Screening For Inhibitors Of Fibroblast To Myofibroblast Transition (fmt)

American journal of respiratory and critical care medicine, 2014-01, Vol.189, p.1

2014

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Solvent effects on manganese(III)-based oxidative free-radical cyclizations: ethanol and acetic acid

Journal of organic chemistry, 1991-09, Vol.56 (19), p.5544-5553

1991

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A60 LUNG FIBROSIS: ANIMAL MODELS I: Discovery Of Itmn-30162: A Pirfenidone Analog With Improved Pharmacokinetics, Anti-Fibrotic Efficacy And Potential For Reduced Gastric Side Effects

American journal of respiratory and critical care medicine, 2014-01, Vol.189, p.1

2014

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A62 LUNG FIBROSIS: FIBROBLAST BIOLOGY: Discovery And Anti-Fibrotic Activity Of Novel Antagonists Of Lysophosphatidic Acid Receptor 1 (lpar1)

American journal of respiratory and critical care medicine, 2014-01, Vol.189, p.1

2014

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Termination of Mn(III)-based oxidative free-radical cyclizations by addition to nitriles. Formation of cyclopentanones and cyclohexanones

Journal of organic chemistry, 1992-01, Vol.57 (1), p.322-326

1992

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Manganese (III) based oxidative free-radical annulations

Tetrahedron, 1989, Vol.45 (22), p.6969-6978

1989

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Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (9), p.2249-2252

2005

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Solid-phase synthesis of 1,3-dialkyl quinazoline-2,4-diones

Tetrahedron letters, 1996-06, Vol.37 (26), p.4439-4442

1996

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Fluorine-18-labeled progestin 16α,17α-dioxolanes : development of high-affinity ligands for the progesterone receptor with high in vivo target site selectivity

Journal of medicinal chemistry, 1995, Vol.38 (2), p.328-337

1995

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Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (19), p.3361-3365

2003

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Design, Synthesis, and Activity of a Novel Series of Factor Xa Inhibitors: Optimization of Arylamidine Groups

Journal of medicinal chemistry, 2002-06, Vol.45 (12), p.2484-2493

2002

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Manganese(III)-based asymmetric oxidative free-radical cyclization of unsaturated .beta.-keto sulfoxides

Journal of organic chemistry, 1991-01, Vol.56 (1), p.328-334

1991

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Design, Synthesis, and Biological Activity of Novel Factor Xa Inhibitors: 4-Aryloxy Substituents of 2,6-Diphenoxypyridines

Bioorganic & medicinal chemistry, 2002-03, Vol.10 (3), p.657-666

2002

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Solution-phase parallel synthesis of benzoxazines using a polymer-supported carbodiimide

Tetrahedron letters, 1998-03, Vol.39 (12), p.1487-1488

1998

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Automated parallel solid-phase synthesis of non-peptide CCR1 receptor antagonists

Combinatorial chemistry & high throughput screening, 2002-05, Vol.5 (3), p.249-251

2002

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Fluorine-18-labeled progestin 16 alpha, 17 alpha-dioxolanes: development of high-affinity ligands for the progesterone receptor with high in vivo target site selectivity

Journal of medicinal chemistry, 1995-01, Vol.38 (2), p.328-337

1995

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Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors

Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor Xa inhibitors

Synthesis and Tissue Biodistribution of [.omega.-11C]Palmitic Acid. A Novel Pet Imaging Agent for Cardiac Fatty acid Metabolism

Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3,5-difluoro- 6-[3-(4,5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylglycine (ZK-807834): A Potent, Selective, and Orally Active Inhibitor of the Blood Coagulation Enzyme Factor Xa

Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1

A62 LUNG FIBROSIS: FIBROBLAST BIOLOGY: Identification Of Novel Small-Molecule Loxl2 Inhibitors By High Throughput Screening

A62 LUNG FIBROSIS: FIBROBLAST BIOLOGY: Impact Of Lpa And Lpa1 Receptor Antagonists On Gene And Protein Expression In Human Primary Cells

A62 LUNG FIBROSIS: FIBROBLAST BIOLOGY: Small-Molecule And Peptide Activators Of The Nrf2-Dependent Antioxidant Response Element

Crystallographic analysis of potent and selective factor Xa inhibitors complexed to bovine trypsin

C58 EMERGING TECHNIQUES AND NEW TOOLS TO UNDERSTAND LUNG DISEASES: Phenotypic Screening For Inhibitors Of Fibroblast To Myofibroblast Transition (fmt)

Solvent effects on manganese(III)-based oxidative free-radical cyclizations: ethanol and acetic acid

A60 LUNG FIBROSIS: ANIMAL MODELS I: Discovery Of Itmn-30162: A Pirfenidone Analog With Improved Pharmacokinetics, Anti-Fibrotic Efficacy And Potential For Reduced Gastric Side Effects

A62 LUNG FIBROSIS: FIBROBLAST BIOLOGY: Discovery And Anti-Fibrotic Activity Of Novel Antagonists Of Lysophosphatidic Acid Receptor 1 (lpar1)

Termination of Mn(III)-based oxidative free-radical cyclizations by addition to nitriles. Formation of cyclopentanones and cyclohexanones

Manganese (III) based oxidative free-radical annulations

Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors

Solid-phase synthesis of 1,3-dialkyl quinazoline-2,4-diones

Fluorine-18-labeled progestin 16α,17α-dioxolanes : development of high-affinity ligands for the progesterone receptor with high in vivo target site selectivity

Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

Design, Synthesis, and Activity of a Novel Series of Factor Xa Inhibitors: Optimization of Arylamidine Groups

Manganese(III)-based asymmetric oxidative free-radical cyclization of unsaturated .beta.-keto sulfoxides

Design, Synthesis, and Biological Activity of Novel Factor Xa Inhibitors: 4-Aryloxy Substituents of 2,6-Diphenoxypyridines

Solution-phase parallel synthesis of benzoxazines using a polymer-supported carbodiimide

Automated parallel solid-phase synthesis of non-peptide CCR1 receptor antagonists

Fluorine-18-labeled progestin 16 alpha, 17 alpha-dioxolanes: development of high-affinity ligands for the progesterone receptor with high in vivo target site selectivity

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