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Quantification of receptor binding from response data obtained at different receptor levels: a simple individual sigmoid fitting and a unified SABRE approach

Scientific reports, 2022-11, Vol.12 (1), p.18833-18833, Article 18833

Buchwald, Peter

2022

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A Receptor Model With Binding Affinity, Activation Efficacy, and Signal Amplification Parameters for Complex Fractional Response Versus Occupancy Data

Frontiers in pharmacology, 2019-06, Vol.10, p.605-605

Buchwald, Peter

2019

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Quantitative receptor model for responses that are left- or right-shifted versus occupancy (are more or less concentration sensitive): the SABRE approach

Frontiers in pharmacology, 2023, Vol.14, p.1274065-1274065

Buchwald, Peter

2023

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Small‐molecule protein–protein interaction inhibitors: Therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations

IUBMB life, 2010-10, Vol.62 (10), p.724-731

Buchwald, Peter

2010

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FEM-based oxygen consumption and cell viability models for avascular pancreatic islets

Theoretical biology and medical modelling, 2009-04, Vol.6 (5), p.5-5, Article 5

Buchwald, Peter

2009

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Toward Small-Molecule Inhibition of Protein-Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions

Current topics in medicinal chemistry, 2018-01, Vol.18 (8), p.674

2018

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Methylene Blue Inhibits the SARS-CoV-2 Spike-ACE2 Protein-Protein Interaction-a Mechanism that can Contribute to its Antiviral Activity Against COVID-19

Frontiers in pharmacology, 2021-01, Vol.11, p.600372

2021

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Concentration-Dependency and Time Profile of Insulin Secretion: Dynamic Perifusion Studies With Human and Murine Islets

Frontiers in endocrinology (Lausanne), 2019-10, Vol.10, p.680-680

2019

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Glucose‐stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets

Biotechnology and bioengineering, 2018-01, Vol.115 (1), p.232-245

2018

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TNF superfamily protein-protein interactions: feasibility of small- molecule modulation

Current drug targets, 2015-01, Vol.16 (4), p.393

2015

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Broad-Spectrum Small-Molecule Inhibitors of the SARS-CoV-2 Spike-ACE2 Protein-Protein Interaction from a Chemical Space of Privileged Protein Binders

Pharmaceuticals (Basel, Switzerland), 2022-08, Vol.15 (9), p.1084

2022

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Oscillatory Dynamics of Cdc42 GTPase in the Control of Polarized Growth

Science (American Association for the Advancement of Science), 2012-07, Vol.337 (6091), p.239-243

2012

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Glucocorticoid receptor binding: A biphasic dependence on molecular size as revealed by the bilinear LinBiExp model

Steroids, 2008-02, Vol.73 (2), p.193-208

Buchwald, Peter

2008

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Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40⁻CD154 Costimulatory Protein-Protein Interaction

Molecules (Basel, Switzerland), 2018-05, Vol.23 (5), p.1153

2018

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A single unified model for fitting simple to complex receptor response data

Scientific reports, 2020-08, Vol.10 (1), p.13386-13386, Article 13386

Buchwald, Peter

2020

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Small-Molecule Inhibitors of the Coronavirus Spike: ACE2 Protein–Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV‑2

ACS infectious diseases, 2021-06, Vol.7 (6), p.1519-1534

2021

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Soft drugs: design principles, success stories, and future perspectives

Expert opinion on drug metabolism & toxicology, 2020-08, Vol.16 (8), p.645-650

Buchwald, Peter

2020

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RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells

Nature communications, 2022-04, Vol.13 (1), p.1815-1815, Article 1815

2022

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Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets

Lab on a chip, 2017, Vol.17 (5), p.772-781

2017

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The food colorant erythrosine is a promiscuous protein–protein interaction inhibitor

Biochemical pharmacology, 2011-03, Vol.81 (6), p.810-818

2011

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The Effect of Recovery Warm-up Time Following Cold Storage on the Dynamic Glucose-stimulated Insulin Secretion of Isolated Human Islets

Cell transplantation, 2020-01, Vol.29, p.963689720908278-963689720908278

2020

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Exploring Computational Data Amplification and Imputation for the Discovery of Type 1 Diabetes (T1D) Biomarkers from Limited Human Datasets

Biomolecules (Basel, Switzerland), 2022-10, Vol.12 (10), p.1444

2022

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Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis

Molecular biology of the cell, 2015-10, Vol.26 (19), p.3520-3534

2015

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A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets

Theoretical biology and medical modelling, 2011-06, Vol.8 (1), p.20-20, Article 20

Buchwald, Peter

2011

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Drug Integrating Amphiphilic Nano-Assemblies: 2. Spatiotemporal Distribution within Inflammation Sites

Pharmaceutics, 2024-05, Vol.16 (5), p.652

2024

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Quantification of receptor binding from response data obtained at different receptor levels: a simple individual sigmoid fitting and a unified SABRE approach

A Receptor Model With Binding Affinity, Activation Efficacy, and Signal Amplification Parameters for Complex Fractional Response Versus Occupancy Data

Quantitative receptor model for responses that are left- or right-shifted versus occupancy (are more or less concentration sensitive): the SABRE approach

Small‐molecule protein–protein interaction inhibitors: Therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations

FEM-based oxygen consumption and cell viability models for avascular pancreatic islets

Toward Small-Molecule Inhibition of Protein-Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions

Methylene Blue Inhibits the SARS-CoV-2 Spike-ACE2 Protein-Protein Interaction-a Mechanism that can Contribute to its Antiviral Activity Against COVID-19

Concentration-Dependency and Time Profile of Insulin Secretion: Dynamic Perifusion Studies With Human and Murine Islets

Glucose‐stimulated insulin release: Parallel perifusion studies of free and hydrogel encapsulated human pancreatic islets

TNF superfamily protein-protein interactions: feasibility of small- molecule modulation

Broad-Spectrum Small-Molecule Inhibitors of the SARS-CoV-2 Spike-ACE2 Protein-Protein Interaction from a Chemical Space of Privileged Protein Binders

Oscillatory Dynamics of Cdc42 GTPase in the Control of Polarized Growth

Glucocorticoid receptor binding: A biphasic dependence on molecular size as revealed by the bilinear LinBiExp model

Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40⁻CD154 Costimulatory Protein-Protein Interaction

A single unified model for fitting simple to complex receptor response data

Small-Molecule Inhibitors of the Coronavirus Spike: ACE2 Protein–Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV‑2

Soft drugs: design principles, success stories, and future perspectives

RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets

The food colorant erythrosine is a promiscuous protein–protein interaction inhibitor

The Effect of Recovery Warm-up Time Following Cold Storage on the Dynamic Glucose-stimulated Insulin Secretion of Isolated Human Islets

Exploring Computational Data Amplification and Imputation for the Discovery of Type 1 Diabetes (T1D) Biomarkers from Limited Human Datasets

Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis

A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets

Drug Integrating Amphiphilic Nano-Assemblies: 2. Spatiotemporal Distribution within Inflammation Sites

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