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A detailed characterization of the hyperpolarization-activated “funny” current (If) in human-induced pluripotent stem cell (iPSC)–derived cardiomyocytes with pacemaker activity

Pflügers Archiv, 2021-07, Vol.473 (7), p.1009-1021

2021

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Exercise training reduces resting heart rate via downregulation of the funny channel HCN4

Nature communications, 2014-05, Vol.5 (1), p.3775-3775, Article 3775

2014

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A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

eLife, 2018-06, Vol.7

2018

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Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4

Proceedings of the National Academy of Sciences - PNAS, 2011-01, Vol.108 (4), p.1705-1710

2011

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Physiology and pharmacology of the cardiac pacemaker ("funny") current

Pharmacology & therapeutics (Oxford), 2005-07, Vol.107 (1), p.59-79

2005

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Chinese natural compound decreases pacemaking of rabbit cardiac sinoatrial cells by targeting second messenger regulation of f-channels

eLife, 2022-03, Vol.11

2022

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Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice

Frontiers in neuroscience, 2021-05, Vol.15, p.617698-617698

2021

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Caveolin-3 and Caveolin-1 Interaction Decreases Channel Dysfunction Due to Caveolin-3 Mutations

International journal of molecular sciences, 2024-01, Vol.25 (2), p.980

2024

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A novel de novo HCN1 loss-of-function mutation in genetic generalized epilepsy causing increased neuronal excitability

Neurobiology of disease, 2018-10, Vol.118, p.55-63

2018

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The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction

Journal of interventional cardiac electrophysiology, 2015-08, Vol.43 (2), p.121-134

2015

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Identification of the molecular site of ivabradine binding to HCN4 channels

PloS one, 2013-01, Vol.8 (1), p.e53132

2013

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Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease

Progress in biophysics and molecular biology, 2021-11, Vol.166, p.61-85

2021

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Current-dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine

The Journal of general physiology, 2002-07, Vol.120 (1), p.1-13

2002

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PITX2 gain-of-function mutation associated with atrial fibrillation alters mitochondrial activity in human iPSC atrial-like cardiomyocytes

Frontiers in physiology, 2023-11, Vol.14, p.1250951-1250951

2023

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Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2

The Journal of general physiology, 2006-11, Vol.128 (5), p.593-604

2006

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Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models

Frontiers in physiology, 2012-01, Vol.3, p.240-240

2012

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Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness

Nature chemical biology, 2014-06, Vol.10 (6), p.457-462

2014

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INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model

Scientific reports, 2016-04, Vol.6 (1), p.24515-24515, Article 24515

2016

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Modulation of cyclic nucleotide-regulated HCN channels by PIP2 and receptors coupled to phospholipase C

Pflügers Archiv, 2007-10, Vol.455 (1), p.125-145

2007

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Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current

Journal of molecular and cellular cardiology, 2007-07, Vol.43 (1), p.39-48

2007

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A Loss-of-Function HCN4 Mutation Associated With Familial Benign Myoclonic Epilepsy in Infancy Causes Increased Neuronal Excitability

Frontiers in molecular neuroscience, 2018-08, Vol.11, p.269-269

2018

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Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker

Circulation (New York, N.Y.), 2006-09, Vol.114 (10), p.992-999

2006

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HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with If blockade

Heart rhythm, 2008-02, Vol.5 (2), p.282-288

2008

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f/HCN channels: From a tiny current controlling cardiac pacemaking to a pleiotropic current all over the body

Progress in biophysics and molecular biology, 2021-11, Vol.166, p.1-2

2021

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A detailed characterization of the hyperpolarization-activated “funny” current (If) in human-induced pluripotent stem cell (iPSC)–derived cardiomyocytes with pacemaker activity

Exercise training reduces resting heart rate via downregulation of the funny channel HCN4

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4

Physiology and pharmacology of the cardiac pacemaker ("funny") current

Chinese natural compound decreases pacemaking of rabbit cardiac sinoatrial cells by targeting second messenger regulation of f-channels

A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate

Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice

Caveolin-3 and Caveolin-1 Interaction Decreases Channel Dysfunction Due to Caveolin-3 Mutations

A novel de novo HCN1 loss-of-function mutation in genetic generalized epilepsy causing increased neuronal excitability

The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction

Identification of the molecular site of ivabradine binding to HCN4 channels

Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease

Current-dependent Block of Rabbit Sino-Atrial Node If Channels by Ivabradine

PITX2 gain-of-function mutation associated with atrial fibrillation alters mitochondrial activity in human iPSC atrial-like cardiomyocytes

Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models

Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness

INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model

Modulation of cyclic nucleotide-regulated HCN channels by PIP2 and receptors coupled to phospholipase C

Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current

A Loss-of-Function HCN4 Mutation Associated With Familial Benign Myoclonic Epilepsy in Infancy Causes Increased Neuronal Excitability

Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker

HCN212-channel biological pacemakers manifesting ventricular tachyarrhythmias are responsive to treatment with If blockade

f/HCN channels: From a tiny current controlling cardiac pacemaking to a pleiotropic current all over the body

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