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Muscarinic and Nicotinic Acetylcholine Receptor Agonists and Allosteric Modulators for the Treatment of Schizophrenia

Neuropsychopharmacology (New York, N.Y.), 2012-01, Vol.37 (1), p.16-42

2012

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Cortical hierarchy governs rat claustrocortical circuit organization

Journal of comparative neurology (1911), 2017-04, Vol.525 (6), p.1347-1362

2017

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Muscarinic receptor pharmacology and circuitry for the modulation of cognition

Handbook of experimental pharmacology, 2012 (208), p.121

2012

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Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Neuropsychopharmacology (New York, N.Y.), 2014-06, Vol.39 (7), p.1578-1593

2014

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Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

ACS chemical neuroscience, 2014-10, Vol.5 (10), p.920-942

2014

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Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist

Neuropharmacology, 2015-08, Vol.95, p.121-129

2015

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Challenges in the development of an M 4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

Bioorganic & medicinal chemistry letters, 2017-01, Vol.27 (2), p.171-175

2017

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Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome

Neurobiology of disease, 2010-09, Vol.39 (3), p.283-291

2010

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State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 – Relation to antipsychotic-like drug effects

Neuropharmacology, 2016-03, Vol.102, p.244-253

2016

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Design and Synthesis of N‑Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs

ACS medicinal chemistry letters, 2017-09, Vol.8 (9), p.925-930

2017

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Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

ACS medicinal chemistry letters, 2017-02, Vol.8 (2), p.233-238

2017

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Discovery and optimization of a novel series of highly CNS penetrant M 4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3- d ]pyrimidine core

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (13), p.3029-3033

2016

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A Rodent Model of Traumatic Stress Induces Lasting Sleep and Quantitative Electroencephalographic Disturbances

ACS chemical neuroscience, 2015-03, Vol.6 (3), p.485-493

2015

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Dopaminergic regulation of orexin neurons

The European journal of neuroscience, 2005-06, Vol.21 (11), p.2993-3001

2005

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Neurotensin Activates GABAergic Interneurons in the Prefrontal Cortex

The Journal of neuroscience, 2005-02, Vol.25 (7), p.1629-1636

2005

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The M4 muscarinic acetylcholine receptor positive allosteric modulator VU0467154 normalizes non‐rapid eye movement sleep deficits in non‐pathologically aged mice

Alzheimer's & dementia, 2023-12, Vol.19, p.n/a

2023

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The M 4 muscarinic acetylcholine receptor positive allosteric modulator VU0467154 normalizes non‐rapid eye movement sleep deficits in non‐pathologically aged mice

Alzheimer's & dementia, 2023-12, Vol.19 (S21)

2023

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Prepulse inhibition of the acoustic startle response of rats is reduced by 6-hydroxydopamine lesions of the medial prefrontal cortex

Psychopharmacologia, 1994, Vol.113 (3-4), p.487-492

1994

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The M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) VU0453595 and M4 PAM VU0467154 Normalize Sleep‐Wake Architecture Deficits in Aged Mice

Alzheimer's & dementia, 2022-12, Vol.18 (S10), p.n/a

2022

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Selective M5 muscarinic acetylcholine receptor negative allosteric modulator VU6008667 blocks acquisition of opioid self-administration

Neuropharmacology, 2023-04, Vol.227, p.109424-109424, Article 109424

2023

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The Neurotensin Agonist PD149163 Increases Fos Expression in the Prefrontal Cortex of the Rat

Neuropsychopharmacology, 2004-10, Vol.29 (10), p.1878-1888

2004

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Deficient Sensorimotor Gating After 6-Hydroxydopamine Lesion of the Rat medial Prefrontal Cortex is Reversed by Haloperidol

The European journal of neuroscience, 1994-12, Vol.6 (12), p.1837-1845

1994

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Age and circadian rhythm‐dependent effects of M 1 muscarinic acetylcholine receptor positive allosteric modulators and donepezil on sleep‐wake architecture and arousal

Alzheimer's & dementia, 2021-12, Vol.17 (S9)

2021

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Age and circadian rhythm‐dependent effects of M1 muscarinic acetylcholine receptor positive allosteric modulators and donepezil on sleep‐wake architecture and arousal

Alzheimer's & dementia, 2021-12, Vol.17, p.n/a

2021

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Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators

Molecular psychiatry, 2020-11, Vol.25 (11), p.2786-2799

2020

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Muscarinic and Nicotinic Acetylcholine Receptor Agonists and Allosteric Modulators for the Treatment of Schizophrenia

Cortical hierarchy governs rat claustrocortical circuit organization

Muscarinic receptor pharmacology and circuitry for the modulation of cognition

Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist

Challenges in the development of an M 4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome

State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 – Relation to antipsychotic-like drug effects

Design and Synthesis of N‑Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs

Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

Discovery and optimization of a novel series of highly CNS penetrant M 4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3- d ]pyrimidine core

A Rodent Model of Traumatic Stress Induces Lasting Sleep and Quantitative Electroencephalographic Disturbances

Dopaminergic regulation of orexin neurons

Neurotensin Activates GABAergic Interneurons in the Prefrontal Cortex

The M4 muscarinic acetylcholine receptor positive allosteric modulator VU0467154 normalizes non‐rapid eye movement sleep deficits in non‐pathologically aged mice

The M 4 muscarinic acetylcholine receptor positive allosteric modulator VU0467154 normalizes non‐rapid eye movement sleep deficits in non‐pathologically aged mice

Prepulse inhibition of the acoustic startle response of rats is reduced by 6-hydroxydopamine lesions of the medial prefrontal cortex

The M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) VU0453595 and M4 PAM VU0467154 Normalize Sleep‐Wake Architecture Deficits in Aged Mice

Selective M5 muscarinic acetylcholine receptor negative allosteric modulator VU6008667 blocks acquisition of opioid self-administration

The Neurotensin Agonist PD149163 Increases Fos Expression in the Prefrontal Cortex of the Rat

Deficient Sensorimotor Gating After 6-Hydroxydopamine Lesion of the Rat medial Prefrontal Cortex is Reversed by Haloperidol

Age and circadian rhythm‐dependent effects of M 1 muscarinic acetylcholine receptor positive allosteric modulators and donepezil on sleep‐wake architecture and arousal

Age and circadian rhythm‐dependent effects of M1 muscarinic acetylcholine receptor positive allosteric modulators and donepezil on sleep‐wake architecture and arousal

Activation of the mGlu1 metabotropic glutamate receptor has antipsychotic-like effects and is required for efficacy of M4 muscarinic receptor allosteric modulators

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