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Reversible, orally available ADP receptor (P2Y12) antagonists Part I: Hit to lead process

Bioorganic & medicinal chemistry letters, 2018-05, Vol.28 (9), p.1459-1463

2018

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Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1

The Journal of biological chemistry, 2005-05, Vol.280 (20), p.19867-19874

2005

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A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) - part I: pharmacological characterization

Thrombosis and haemostasis, 2007-01, Vol.97 (1), p.45

2007

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Host-guest complexation. 62. Solvophobic and entropic driving forces for forming velcraplexes, which are 4-fold, lock-key dimers in organic media

Journal of the American Chemical Society, 1992-09, Vol.114 (20), p.7748-7765

1992

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Potent Triazolothione Inhibitor of Heat-Shock Protein-90

Chemical biology & drug design, 2009-07, Vol.74 (1), p.43-50

2009

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Host-guest complexation. 48. Octol building blocks for cavitands and carcerands

Journal of organic chemistry, 1989-03, Vol.54 (6), p.1305-1312

1989

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Vases and kites as cavitands

Journal of the American Chemical Society, 1991-07, Vol.113 (15), p.5707-5714

1991

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Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis

Bioorganic & medicinal chemistry letters, 2018-11, Vol.28 (20), p.3372-3375

2018

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Host-guest complexation. 55. Guest capture during shell closure

Journal of the American Chemical Society, 1991-03, Vol.113 (6), p.2167-2172

1991

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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX- 517

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3819-3825

2007

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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3814-3818

2007

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Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA)

Bioorganic & medicinal chemistry letters, 2009-10, Vol.19 (19), p.5712-5715

2009

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Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): Pharmacodynamic and pharmacokinetic characterization

Thrombosis research, 2008, Vol.122 (4), p.533-540

2008

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A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models

Thrombosis and haemostasis, 2007-05, Vol.97 (5), p.847

2007

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3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa)

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (5), p.1349-1354

2007

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High preorganization of large lipophilic surfaces common to two complexing partners provides high binding free energies that vary dramatically with changes in organic solvent composition

Journal of the American Chemical Society, 1990-01, Vol.112 (3), p.1255-1256

1990

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Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I): In vitro effects on platelets

Thrombosis research, 2008, Vol.122 (4), p.523-532

2008

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Crystal Structures of Potent Thiol-Based Inhibitors Bound to Carboxypeptidase B

Biochemistry (Easton), 2005-07, Vol.44 (26), p.9339-9347

2005

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Solvophobic and entropic driving forces for forming velcraplexes, which are four-fold, lock-key dimers in organic media

Journal of the American Chemical Society, 1992-09, Vol.114 (20), p.7748-7765

1992

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Challenges in measuring the impact of interruption on patient safety and workflow outcomes

Methods of information in medicine, 2011-01, Vol.50 (5), p.447

2011

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Novel P2Y 12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): Pharmacodynamic and pharmacokinetic characterization

Thrombosis research, 2008, Vol.122 (4), p.533-540

2008

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Host-guest complexation. 54. Spherands containing cyclic urea units

Journal of the American Chemical Society, 1990-07, Vol.112 (15), p.5837-5843

1990

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Novel P2Y 12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I): In vitro effects on platelets

Thrombosis research, 2008, Vol.122 (4), p.523-532

2008

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Structures of potent selective peptide mimetics bound to carboxypeptidase B

Acta crystallographica. Section D, Biological crystallography., 2008-02, Vol.64 (2), p.149-157

2008

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Organic molecules dimerize with high structural recognition when each possesses a large lipophilic surface containing two preorganized and complementary host and guest regions

Journal of the American Chemical Society, 1990-01, Vol.112 (3), p.1254-1255

1990

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Reversible, orally available ADP receptor (P2Y12) antagonists Part I: Hit to lead process

Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1

A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) - part I: pharmacological characterization

Host-guest complexation. 62. Solvophobic and entropic driving forces for forming velcraplexes, which are 4-fold, lock-key dimers in organic media

Potent Triazolothione Inhibitor of Heat-Shock Protein-90

Host-guest complexation. 48. Octol building blocks for cavitands and carcerands

Vases and kites as cavitands

Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis

Host-guest complexation. 55. Guest capture during shell closure

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX- 517

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity

Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA)

Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): Pharmacodynamic and pharmacokinetic characterization

A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models

3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa)

High preorganization of large lipophilic surfaces common to two complexing partners provides high binding free energies that vary dramatically with changes in organic solvent composition

Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I): In vitro effects on platelets

Crystal Structures of Potent Thiol-Based Inhibitors Bound to Carboxypeptidase B

Solvophobic and entropic driving forces for forming velcraplexes, which are four-fold, lock-key dimers in organic media

Challenges in measuring the impact of interruption on patient safety and workflow outcomes

Novel P2Y 12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): Pharmacodynamic and pharmacokinetic characterization

Host-guest complexation. 54. Spherands containing cyclic urea units

Novel P2Y 12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (I): In vitro effects on platelets

Structures of potent selective peptide mimetics bound to carboxypeptidase B

Organic molecules dimerize with high structural recognition when each possesses a large lipophilic surface containing two preorganized and complementary host and guest regions

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