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Short-course IL-15 given as a continuous infusion led to a massive expansion of effective NK cells: implications for combination therapy with antitumor antibodies

Journal for immunotherapy of cancer, 2021-04, Vol.9 (4), p.e002193

2021

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Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia

Translational oncology, 2021-01, Vol.14 (1), p.100913-100913, Article 100913

2021

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Accessory cells precondition naïve T cells and regulatory T cells for cytokine-mediated proliferation

Proceedings of the National Academy of Sciences - PNAS, 2023-04, Vol.120 (15), p.e2217562120-e2217562120

2023

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Clinical trial of a humanized anti‐IL‐2/IL‐15 receptor β chain in HAM/TSP

Annals of clinical and translational neurology, 2019-08, Vol.6 (8), p.1383-1394

2019

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IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion

Clinical cancer research, 2019-08, Vol.25 (16), p.4945-4954

2019

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Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma

Cancer cell, 2018-08, Vol.34 (2), p.286-297.e10

2018

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Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia

Blood, 2013-01, Vol.121 (3), p.476-484

2013

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CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP

Blood, 2011-02, Vol.117 (6), p.1938-1946

2011

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Triple combination of BET plus PI3K and NF-κB inhibitors exhibit synergistic activity in adult T-cell leukemia/lymphoma

Blood advances, 2022-04, Vol.6 (7), p.2346-2360

2022

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Autocrine/paracrine cytokine stimulation of leukemic cell proliferation in smoldering and chronic adult T-cell leukemia

Blood, 2010-12, Vol.116 (26), p.5948-5956

2010

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90 Y-Daclizumab (Anti-CD25), High-Dose Carmustine, Etoposide, Cytarabine, and Melphalan Chemotherapy and Autologous Hematopoietic Stem Cell Transplant Yielded Sustained Complete Remissions in 4 Patients with Recurrent Hodgkin's Lymphoma

Cancer biotherapy & radiopharmaceuticals, 2020-05, Vol.35 (4), p.249

2020

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IL15 Infusion of Cancer Patients Expands the Subpopulation of Cytotoxic CD56bright NK Cells and Increases NK-Cell Cytokine Release Capabilities

Cancer immunology research, 2017-10, Vol.5 (10), p.929-938

2017

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90Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin’s lymphoma

Proceedings of the National Academy of Sciences - PNAS, 2015-10, Vol.112 (42), p.13045-13050

2015

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Genetic analysis of synchronous mucinous tumors of the ovary and appendix

Human pathology, 1996-02, Vol.27 (2), p.165-171

1996

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Accessory cells precondition naive T cells and regulatory T cells for cytokine-mediated proliferation

The Journal of immunology (1950), 2023-05, Vol.210 (1_Supplement), p.164-164.02

2023

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Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism

Blood, 2008-05, Vol.111 (10), p.5163-5172

2008

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IL-15 by continuous i.v. infusion to adult patients with solid tumors in a Phase I trial induced dramatic NK cell subset expansion

Clinical cancer research, 2019-05, Vol.25 (16), p.4945-4954

2019

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Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T-Cell Leukemia/Lymphoma

Blood, 2017-12, Vol.130 (Suppl_1), p.731-731

2017

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90 Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin’s lymphoma

Proceedings of the National Academy of Sciences - PNAS, 2015-10, Vol.112 (42), p.13045-13050

2015

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sup 90^Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin's lymphoma

Proceedings of the National Academy of Sciences - PNAS, 2015-10, Vol.112 (42), p.13045

2015

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super( 90)Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin's lymphoma

Proceedings of the National Academy of Sciences - PNAS, 2015-10, Vol.112 (42), p.13045-13045

2015

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IL15 Infusion of Cancer Patients Expands the Subpopulation of Cytotoxic CD56 bright NK Cells and Increases NK-Cell Cytokine Release Capabilities

Cancer immunology research, 2017-10, Vol.5 (10), p.929

2017

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Genetic Changes in Chromosomes 1p and 17p in Thyroid Cancer Progression

Endocrine pathology, 2000, Vol.11 (2), p.137-144

2000

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Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques

Short-course IL-15 given as a continuous infusion led to a massive expansion of effective NK cells: implications for combination therapy with antitumor antibodies

Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia

Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer

Accessory cells precondition naïve T cells and regulatory T cells for cytokine-mediated proliferation

Clinical trial of a humanized anti‐IL‐2/IL‐15 receptor β chain in HAM/TSP

IL15 by Continuous Intravenous Infusion to Adult Patients with Solid Tumors in a Phase I Trial Induced Dramatic NK-Cell Subset Expansion

Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma

Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia

CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP

Triple combination of BET plus PI3K and NF-κB inhibitors exhibit synergistic activity in adult T-cell leukemia/lymphoma

Autocrine/paracrine cytokine stimulation of leukemic cell proliferation in smoldering and chronic adult T-cell leukemia

90 Y-Daclizumab (Anti-CD25), High-Dose Carmustine, Etoposide, Cytarabine, and Melphalan Chemotherapy and Autologous Hematopoietic Stem Cell Transplant Yielded Sustained Complete Remissions in 4 Patients with Recurrent Hodgkin's Lymphoma

IL15 Infusion of Cancer Patients Expands the Subpopulation of Cytotoxic CD56bright NK Cells and Increases NK-Cell Cytokine Release Capabilities

90Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin’s lymphoma

Genetic analysis of synchronous mucinous tumors of the ovary and appendix

Accessory cells precondition naive T cells and regulatory T cells for cytokine-mediated proliferation

Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism

IL-15 by continuous i.v. infusion to adult patients with solid tumors in a Phase I trial induced dramatic NK cell subset expansion

Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T-Cell Leukemia/Lymphoma

90 Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin’s lymphoma

sup 90^Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin's lymphoma

super( 90)Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin's lymphoma

IL15 Infusion of Cancer Patients Expands the Subpopulation of Cytotoxic CD56 bright NK Cells and Increases NK-Cell Cytokine Release Capabilities

Genetic Changes in Chromosomes 1p and 17p in Thyroid Cancer Progression

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