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The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule

Pflügers Archiv, 2012-12, Vol.464 (6), p.601-611

2012

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Development of a Highly Differentiated Human Primary Proximal Tubule MPS Model (aProximate MPS Flow)

Bioengineering (Basel), 2024-01, Vol.11 (1), p.7

2024

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The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance

Drug metabolism and disposition, 2018-10, Vol.46 (10), p.1441-1445

2018

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Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic Clearance

Drug metabolism and disposition, 2017-05, Vol.45 (5), p.556-568

2017

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Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling

Toxicology and applied pharmacology, 2008-12, Vol.233 (3), p.428-438

2008

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Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine

Clinical pharmacology and therapeutics, 2004-08, Vol.76 (2), p.167-177

2004

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The effect of gemfibrozil on the pharmacokinetics of rosuvastatin

Clinical pharmacology and therapeutics, 2004-05, Vol.75 (5), p.455-463

2004

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Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics

Drug metabolism and disposition, 2016-12, Vol.44 (12), p.1920-1924

2016

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Human Proximal Tubular Epithelium Actively Secretes but Does Not Retain Rosuvastatin

Molecular pharmacology, 2008-10, Vol.74 (4), p.1084-1091

2008

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Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines

Toxicology letters, 2015-06, Vol.235 (3), p.189-198

2015

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Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo

Biochemical pharmacology, 2013-01, Vol.85 (1), p.29-37

2013

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Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies

Toxicological sciences, 2014-02, Vol.137 (2), p.350-370

2014

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Characterization of MPP+ secretion across human intestinal Caco‐2 cell monolayers: role of P‐glycoprotein and a novel Na+‐dependent organic cation transport mechanism

British journal of pharmacology, 2000-02, Vol.129 (3), p.619-625

2000

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Abstract 5447: Investigating the relationship between pharmacogenetic variation in ABCB1 and ABCC2 tagSNPs and actinomycin D pharmacokinetics in children

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.5447-5447

2011

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The organic cation transporter OCT2 mediates the uptake of β ‐adrenoceptor antagonists across the apical membrane of renal LLC‐PK 1 cell monolayers

British journal of pharmacology, 2009-01, Vol.131 (1), p.71-79

2009

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Renal differentiation from adult spermatogonial stem cells

Renal failure, 2013-11, Vol.35 (10), p.1387-1391

2013

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The organic cation transporter OCT2 mediates the uptake of β‐adrenoceptor antagonists across the apical membrane of renal LLC‐PK1 cell monolayers

British journal of pharmacology, 2000-09, Vol.131 (1), p.71-79

2000

Volltextzugriff (PDF)

The organic cation transporter OCT2 mediates the uptake of [beta]-adrenoceptor antagonists across the apical membrane of renal LLC-PK1 cell monolayers

British journal of pharmacology, 2000-09, Vol.131 (1), p.71

2000

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Na-K-Cl cotransport in villus and crypt cells from rat duodenum

American journal of physiology: Gastrointestinal and liver physiology, 1994-12, Vol.30 (6), p.G1004-G1011

1994

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Characterization of a Na∶K∶2Cl cotransport system in the apical membrane of a renal epithelial cell line (LLC-PK1)

The Journal of membrane biology, 1985-01, Vol.87 (2), p.131-139

1985

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Pharmacogenomic Prediction of Anthracycline-Induced Cardiotoxicity in Children

Journal of clinical oncology, 2012-05, Vol.30 (13), p.1422-1428

2012

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IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

FEBS letters, 2009-06, Vol.583 (12), p.1817-1824

2009

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Shifting global Larix distributions: Northern expansion and southern retraction as species respond to changing climate

Journal of biogeography, 2019-01, Vol.46 (1), p.30-44

2019

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A randomized, placebo-controlled trial of online cognitive behavioral therapy for chronic insomnia disorder delivered via an automated media-rich web application

Sleep (New York, N.Y.), 2012-06, Vol.35 (6), p.769-781

2012

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The limitations of renal epithelial cell line HK-2 as a model of drug transporter expression and function in the proximal tubule

Development of a Highly Differentiated Human Primary Proximal Tubule MPS Model (aProximate MPS Flow)

The Importance of Incorporating OCT2 Plasma Membrane Expression and Membrane Potential in IVIVE of Metformin Renal Secretory Clearance

Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic Clearance

Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling

Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine

The effect of gemfibrozil on the pharmacokinetics of rosuvastatin

Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics

Human Proximal Tubular Epithelium Actively Secretes but Does Not Retain Rosuvastatin

Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines

Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo

Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studies

c-Rel orchestrates energy-dependent epithelial and macrophage reprogramming in fibrosis

Characterization of MPP+ secretion across human intestinal Caco‐2 cell monolayers: role of P‐glycoprotein and a novel Na+‐dependent organic cation transport mechanism

Abstract 5447: Investigating the relationship between pharmacogenetic variation in ABCB1 and ABCC2 tagSNPs and actinomycin D pharmacokinetics in children

The organic cation transporter OCT2 mediates the uptake of β ‐adrenoceptor antagonists across the apical membrane of renal LLC‐PK 1 cell monolayers

Renal differentiation from adult spermatogonial stem cells

The organic cation transporter OCT2 mediates the uptake of β‐adrenoceptor antagonists across the apical membrane of renal LLC‐PK1 cell monolayers

The organic cation transporter OCT2 mediates the uptake of [beta]-adrenoceptor antagonists across the apical membrane of renal LLC-PK1 cell monolayers

Na-K-Cl cotransport in villus and crypt cells from rat duodenum

Characterization of a Na∶K∶2Cl cotransport system in the apical membrane of a renal epithelial cell line (LLC-PK1)

Pharmacogenomic Prediction of Anthracycline-Induced Cardiotoxicity in Children

IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

Shifting global Larix distributions: Northern expansion and southern retraction as species respond to changing climate

A randomized, placebo-controlled trial of online cognitive behavioral therapy for chronic insomnia disorder delivered via an automated media-rich web application

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