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KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma

Current neuropharmacology, 2018-01, Vol.16 (5), p.618-626

2018

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Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1- d ]oxazol-2-amine (SKA-121)

Molecular pharmacology, 2017-10, Vol.92 (4), p.469-480

2017

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The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators

Frontiers in pharmacology, 2019-09, Vol.10, p.972-972

2019

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The Riluzole Derivative 2-Amino-6-trifluoromethylthio-benzothiazole (SKA-19), a Mixed KCa2 Activator and NaV Blocker, is a Potent Novel Anticonvulsant

Neurotherapeutics, 2015, Vol.12 (1), p.234-249

2015

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Recent advances in our understanding of the structure and function of more unusual cation channels [version 1; peer review: 2 approved]

F1000 research, 2019, Vol.8, p.123

2019

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A non-hallucinogenic psychedelic analogue with therapeutic potential

Nature (London), 2021-01, Vol.589 (7842), p.474-479

2021

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When Does the IC50 Accurately Assess the Blocking Potency of a Drug?

Journal of chemical information and modeling, 2020-03, Vol.60 (3), p.1779-1790

2020

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Computer vision for automated seizure detection and classification: A systematic review

Epilepsia (Copenhagen), 2024-05, Vol.65 (5), p.1176-1202

2024

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Changes in Politics and Religiosity Among Students at a Protestant University

Journal for the scientific study of religion, 2024-03, Vol.63 (1), p.117-136

2024

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Explaining the Relationship between Religiosity and Political Participation: The Mediating Roles of Transcendent Accountability and Religiopolitical Awareness

Journal for the scientific study of religion, 2023-09, Vol.62 (3), p.549-579

2023

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When Does the IC 50 Accurately Assess the Blocking Potency of a Drug?

Journal of chemical information and modeling, 2020-03, Vol.60 (3), p.1779-1790

2020

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The Trials and Tribulations of Structure Assisted Design of K Ca Channel Activators

Frontiers in pharmacology, 2019-09, Vol.10, p.972

2019

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Are there superagonists for calcium-activated potassium channels?

Channels (Austin, Tex.), 2017-11, Vol.11 (6), p.504-506

2017

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A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain

Neuropharmacology, 2017-07, Vol.121, p.204-218

2017

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Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content

The international journal of biochemistry & cell biology, 2016-07, Vol.76, p.19-30

2016

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A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo

Molecular pharmacology, 2015-02, Vol.87 (2), p.338-348

2015

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New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1

Molecular pharmacology, 2014-09, Vol.86 (3), p.342-357

2014

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Development of a QPatch automated electrophysiology assay for identifying KCa3.1 inhibitors and activators

Assay and drug development technologies, 2013-12, Vol.11 (9-10), p.551

2013

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Mechanism of Gating of the Intermediate-Conductance Calcium-Activated Potassium Channel (KCa3.1)

Biophysical journal, 2018-02, Vol.114 (3), p.308a-309a

2018

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Structure Assisted Design of Small Molecule KCa Channel Modulators

The FASEB journal, 2018-04, Vol.32 (S1), p.556.1-556.1

2018

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Structural Determinants for Selectivity of the Positive KCa Channel Gating Modulator, SKA-121

Biophysical journal, 2016-02, Vol.110 (3), p.114a-114a

2016

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Positive KCa Channel Gating Modulators with Selectivity for KCa3.1

Biophysical journal, 2015-01, Vol.108 (2), p.20a-20a

2015

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Molecular Determinants of Steroid Hormone and Drug Induced Arrhythmogenesis via hERG Channel Block

Biophysical journal, 2018-02, Vol.114 (3), p.486a-486a

2018

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IC50 evaluation is critically dependent on the protocol used for measurement

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106807, Article 106807

2020

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KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma

Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1- d ]oxazol-2-amine (SKA-121)

The Trials and Tribulations of Structure Assisted Design of KCa Channel Activators

Conditional KCa3.1-transgene induction in murine skin produces pruritic eczematous dermatitis with severe epidermal hyperplasia and hyperkeratosis

The Riluzole Derivative 2-Amino-6-trifluoromethylthio-benzothiazole (SKA-19), a Mixed KCa2 Activator and NaV Blocker, is a Potent Novel Anticonvulsant

Recent advances in our understanding of the structure and function of more unusual cation channels [version 1; peer review: 2 approved]

A non-hallucinogenic psychedelic analogue with therapeutic potential

When Does the IC50 Accurately Assess the Blocking Potency of a Drug?

Computer vision for automated seizure detection and classification: A systematic review

Changes in Politics and Religiosity Among Students at a Protestant University

Explaining the Relationship between Religiosity and Political Participation: The Mediating Roles of Transcendent Accountability and Religiopolitical Awareness

When Does the IC 50 Accurately Assess the Blocking Potency of a Drug?

The Trials and Tribulations of Structure Assisted Design of K Ca Channel Activators

Are there superagonists for calcium-activated potassium channels?

A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain

Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content

A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo

New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1

Development of a QPatch automated electrophysiology assay for identifying KCa3.1 inhibitors and activators

Mechanism of Gating of the Intermediate-Conductance Calcium-Activated Potassium Channel (KCa3.1)

Structure Assisted Design of Small Molecule KCa Channel Modulators

Structural Determinants for Selectivity of the Positive KCa Channel Gating Modulator, SKA-121

Positive KCa Channel Gating Modulators with Selectivity for KCa3.1

Molecular Determinants of Steroid Hormone and Drug Induced Arrhythmogenesis via hERG Channel Block

IC50 evaluation is critically dependent on the protocol used for measurement

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