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New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides

Chemical research in toxicology, 2020-07, Vol.33 (7), p.1551-1560

2020

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The N‐Acetylgalactosamine‐conjugated small interfering RNA inclisiran can be coadministered safely with atorvastatin in cynomolgus monkeys resulting in additive low‐density lipoprotein cholesterol reductions

Pharmacology research & perspectives, 2023-04, Vol.11 (2), p.e01080-n/a

2023

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Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration

Cancer chemotherapy and pharmacology, 2007-04, Vol.59 (5), p.671-679

2007

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Immune Responses in Human Necatoriasis: Association between Interleukin-5 Responses and Resistance to Reinfection

The Journal of infectious diseases, 2004-08, Vol.190 (3), p.430-438

2004

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Antigen-driven basophil activation is indicative of early Necator americanus infection in IgE-seronegative patients

Journal of allergy and clinical immunology, 2009-12, Vol.124 (6), p.1343-1350.e7

2009

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Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino )-17-demethoxygeldanamycin (17-DMAG), in rats and dogs : potential clinical relevance

Cancer chemotherapy and pharmacology, 2005-12, Vol.56 (6), p.637-647

2005

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Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study, Not Predicted by Standard In Vitro Ion Channel Assays

International journal of toxicology, 2024-06, Vol.43 (3), p.231-242

2024

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Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors

Biochemical pharmacology, 2023-03, Vol.209, p.115418, Article 115418

2023

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Degradation of MSCRAMM target macromolecules in VLU slough by Lucilia sericata chymotrypsin 1 (ISP) persists in the presence of tissue gelatinase activity

International wound journal, 2015-08, Vol.12 (4), p.414-421

2015

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Cartilage Dysplasia and Tissue Mineralization in the Rat Following Administration of a FGF Receptor Tyrosine Kinase Inhibitor

Toxicologic pathology, 2005-01, Vol.33 (4), p.449-455

2005

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Graphical display of histopathology data from toxicology studies for drug discovery and development: An industry perspective

Regulatory toxicology and pharmacology, 2016-12, Vol.82, p.167-172

2016

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Mortality Associated With Opioid Overdose: A Review of Clinical Characteristics and Health Services Received in the Year Prior to Death

Psychiatric services (Washington, D.C.), 2019-02, Vol.70 (2), p.90-96

2019

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Cutaneous Lesions in the Rat Following Administration of an Irreversible Inhibitor of erbB Receptors, Including the Epidermal Growth Factor Receptor

Toxicologic pathology, 2008-04, Vol.36 (3), p.410-419

2008

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Species-specific Bioactivation of Morpholines as a Causative of Drug Induced Liver Injury Observed in Monkeys

Drug Metabolism and Bioanalysis Letters, 2024-01, Vol.17 (1), p.13-22

2024

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Correlation Between Nasal Epithelial Injury and In Vitro Cytotoxicity Using a Series of Small Molecule Protein Tyrosine Phosphatase 1B Inhibitors Investigated for Reversal of Leptin Resistance in Obesity

International journal of toxicology, 2017-07, Vol.36 (4), p.303-313

2017

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Development of methods to measure humoral immune responses against selected antigens in the common marmoset ( Callithrix jacchus) and the effect of pyridostigmine bromide administration

International immunopharmacology, 2006-12, Vol.6 (12), p.1755-1764

2006

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Manic episode after total abdominal hysterectomy with bilateral salpingo-oophorectomy: case report

Menopause (New York, N.Y.), 2012-04, Vol.19 (4), p.476-478

2012

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Ascaris suum-Derived Products Induce Human Neutrophil Activation via a G Protein-Coupled Receptor That Interacts with the Interleukin-8 Receptor Pathway

Infection and Immunity, 2001-06, Vol.69 (6), p.4007-4018

2001

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Interconnectivity of Disparate Nonclinical Data Silos for Drug Discovery and Development

Therapeutic innovation & regulatory science, 2014-07, Vol.48 (4), p.498-506

2014

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Toxicity and toxicokinetics of the cyclin-dependent kinase inhibitor AG-024322 in cynomolgus monkeys following intravenous infusion

Cancer chemotherapy and pharmacology, 2008-11, Vol.62 (6), p.1091-1101

2008

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A practical guide to study directing

The quality assurance journal, 2009-01, Vol.12 (1), p.40-50

Brown, Alan P.

2009

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Development of a model of hookworm infection exhibiting salient characteristics of human infection

The American journal of tropical medicine and hygiene, 2008-06, Vol.78 (6), p.936-945

2008

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Cyclic and differential pulse voltammetric behavior of reactants confined to the electrode surface

Analytical chemistry (Washington), 1977-09, Vol.49 (11), p.1589-1595

1977

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Preclinical toxicity studies of kahalalide F, a new anticancer agent: single and multiple dosing regimens in the rat

Cancer chemotherapy and pharmacology, 2002-10, Vol.50 (4), p.333-340

2002

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New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides

The N‐Acetylgalactosamine‐conjugated small interfering RNA inclisiran can be coadministered safely with atorvastatin in cynomolgus monkeys resulting in additive low‐density lipoprotein cholesterol reductions

Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration

Immune Responses in Human Necatoriasis: Association between Interleukin-5 Responses and Resistance to Reinfection

Antigen-driven basophil activation is indicative of early Necator americanus infection in IgE-seronegative patients

Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino )-17-demethoxygeldanamycin (17-DMAG), in rats and dogs : potential clinical relevance

Electrophysiological Changes in the Rabbit Ventricular Wedge and Human-Induced Pluripotent Stem-Cell Derived (IPSC) Cardiomyocytes Translate to Severe Arrhythmia Observed in a Canine Toxicology Study, Not Predicted by Standard In Vitro Ion Channel Assays

Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors

Degradation of MSCRAMM target macromolecules in VLU slough by Lucilia sericata chymotrypsin 1 (ISP) persists in the presence of tissue gelatinase activity

Cartilage Dysplasia and Tissue Mineralization in the Rat Following Administration of a FGF Receptor Tyrosine Kinase Inhibitor

Graphical display of histopathology data from toxicology studies for drug discovery and development: An industry perspective

Mortality Associated With Opioid Overdose: A Review of Clinical Characteristics and Health Services Received in the Year Prior to Death

Cutaneous Lesions in the Rat Following Administration of an Irreversible Inhibitor of erbB Receptors, Including the Epidermal Growth Factor Receptor

Species-specific Bioactivation of Morpholines as a Causative of Drug Induced Liver Injury Observed in Monkeys

Correlation Between Nasal Epithelial Injury and In Vitro Cytotoxicity Using a Series of Small Molecule Protein Tyrosine Phosphatase 1B Inhibitors Investigated for Reversal of Leptin Resistance in Obesity

Development of methods to measure humoral immune responses against selected antigens in the common marmoset ( Callithrix jacchus) and the effect of pyridostigmine bromide administration

Manic episode after total abdominal hysterectomy with bilateral salpingo-oophorectomy: case report

Ascaris suum-Derived Products Induce Human Neutrophil Activation via a G Protein-Coupled Receptor That Interacts with the Interleukin-8 Receptor Pathway

Interconnectivity of Disparate Nonclinical Data Silos for Drug Discovery and Development

Toxicity and toxicokinetics of the cyclin-dependent kinase inhibitor AG-024322 in cynomolgus monkeys following intravenous infusion

Antibacterial Oxazolidinones Possessing a Novel C-5 Side Chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic Acid Amide (PF-00422602), a New Lead Compound

A practical guide to study directing

Development of a model of hookworm infection exhibiting salient characteristics of human infection

Cyclic and differential pulse voltammetric behavior of reactants confined to the electrode surface

Preclinical toxicity studies of kahalalide F, a new anticancer agent: single and multiple dosing regimens in the rat

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