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Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

Digestive diseases and sciences, 2015-11, Vol.60 (11), p.3318-3328

2015

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Producing circular field harmonics inside elliptic magnet apertures with superconducting canted-cosine-theta coils

Physical review. Accelerators and beams, 2024-02, Vol.27 (2), p.022402

Brouwer, L.

2024

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Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

Pharmaceutical research, 2024-03, Vol.41 (3), p.441-462

2024

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Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences

PloS one, 2022-12, Vol.17 (12), p.e0278297-e0278297

2022

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Improving automatic delineation for head and neck organs at risk by Deep Learning Contouring

Radiotherapy and oncology, 2020-01, Vol.142, p.115-123

2020

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Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

Clinical pharmacology and therapeutics, 2015-09, Vol.98 (3), p.266-287

2015

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CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines

Radiotherapy and oncology, 2015-10, Vol.117 (1), p.83-90

2015

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Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation

The Journal of pharmacology and experimental therapeutics, 2016-08, Vol.358 (2), p.324

2016

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Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

Pharmaceutical research, 2023-11, Vol.40 (11), p.2513-2523

2023

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Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes

The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.727

2013

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A Perspective on Efflux Transport Proteins in the Liver

Clinical pharmacology and therapeutics, 2012-11, Vol.92 (5), p.599-612

2012

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Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates

PloS one, 2019-09, Vol.14 (9), p.e0222422-e0222422

2019

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An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

Journal of pharmaceutical sciences, 2013-09, Vol.102 (9), p.3037-3057

2013

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Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4

Drug metabolism and disposition, 2014-04, Vol.42 (4), p.665

2014

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In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

Clinical pharmacology and therapeutics, 2013-07, Vol.94 (1), p.95-112

2013

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Identifying patients who may benefit from adaptive radiotherapy: Does the literature on anatomic and dosimetric changes in head and neck organs at risk during radiotherapy provide information to help?

Radiotherapy and oncology, 2015-06, Vol.115 (3), p.285-294

2015

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Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids

Analytical chemistry (Washington), 2016-07, Vol.88 (14), p.7041-7048

2016

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Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids

Analytical and bioanalytical chemistry, 2018-08, Vol.410 (21), p.5287-5300

2018

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Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

Clinical pharmacology and therapeutics, 2013-07, Vol.94 (1), p.126-141

2013

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A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity

Scientific reports, 2022-08, Vol.12 (1), p.14333-14333, Article 14333

2022

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The complexities of hepatic drug transport: current knowledge and emerging concepts

Pharmaceutical research, 2004-05, Vol.21 (5), p.719-735

2004

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Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?

Toxicological sciences, 2016-01, Vol.149 (1), p.237-250

2016

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Influence of Drug Transport Proteins on the Pharmacokinetics and Drug Interactions of Hiv Protease Inhibitors

Journal of pharmaceutical sciences, 2011-09, Vol.100 (9), p.3636-3654

2011

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Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer’s Disease

Molecular pharmaceutics, 2018-09, Vol.15 (9), p.4073-4083

2018

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Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications

Clinical pharmacology and therapeutics, 2021-01, Vol.109 (1), p.55-64

2021

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Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

Producing circular field harmonics inside elliptic magnet apertures with superconducting canted-cosine-theta coils

Physiologically Based Pharmacokinetic (PBPK) Model Predictions of Disease Mediated Changes in Drug Disposition in Patients with Nonalcoholic Fatty Liver Disease (NAFLD)

Developing evidence-based resources for evaluating postgraduate trainees in the biomedical sciences

Improving automatic delineation for head and neck organs at risk by Deep Learning Contouring

Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

CT-based delineation of organs at risk in the head and neck region: DAHANCA, EORTC, GORTEC, HKNPCSG, NCIC CTG, NCRI, NRG Oncology and TROG consensus guidelines

Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation

Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers

Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes

A Perspective on Efflux Transport Proteins in the Liver

Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates

An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4

In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

Identifying patients who may benefit from adaptive radiotherapy: Does the literature on anatomic and dosimetric changes in head and neck organs at risk during radiotherapy provide information to help?

Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids

Analysis of human C24 bile acids metabolome in serum and urine based on enzyme digestion of conjugated bile acids and LC-MS determination of unconjugated bile acids

Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity

The complexities of hepatic drug transport: current knowledge and emerging concepts

Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?

Influence of Drug Transport Proteins on the Pharmacokinetics and Drug Interactions of Hiv Protease Inhibitors

Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer’s Disease

Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications

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