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Structural basis of VHH-mediated neutralization of the food-borne pathogen Listeria monocytogenes

The Journal of biological chemistry, 2018-08, Vol.293 (35), p.13626-13635

2018

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Glycosylation of MUC1 influences the binding of a therapeutic antibody by altering the conformational equilibrium of the antigen

Glycobiology (Oxford), 2017-07, Vol.27 (7), p.677-687

2017

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Role of a noncanonical disulfide bond in the stability, affinity, and flexibility of a VHH specific for the Listeria virulence factor InlB

Protein science, 2020-04, Vol.29 (4), p.1004-1017

2020

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Structure of a VHH isolated from a naïve phage display library

BMC research notes, 2019-03, Vol.12 (1), p.154-154, Article 154

2019

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Antibody recognition of a unique tumor-specific glycopeptide antigen

Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (22), p.10056-10061

2010

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Crystal structure of a human MUC16 SEA domain reveals insight into the nature of the CA125 tumor marker

Proteins, structure, function, and bioinformatics, 2022-05, Vol.90 (5), p.1210-1218

2022

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Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS

Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (51), p.20877-20882

2012

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Experimental Determination of Antibody Affinity and Avidity: Guidance and Considerations

Monoclonal antibodies in immunodiagnosis and immunotherapy, 2024-10

2024

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Charting the Course for Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

Monoclonal antibodies in immunodiagnosis and immunotherapy, 2024-06, Vol.43 (3), p.83-84

2024

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Directed Evolution of the Escherichia coli cAMP Receptor Protein at the cAMP Pocket

The Journal of biological chemistry, 2015-10, Vol.290 (44), p.26587-26596

2015

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Understanding the Role of Cancer Glycosylation on Antibody Binding to MUC16

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Modular Cloning of MUC1 Recombinant Antibodies by Assembly of Synthetic Domain Genes

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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X-ray Crystal Structure Analysis of VHH-Protein Antigen Complexes

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2446, p.513

2022

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Immunological Functions and Evolutionary Emergence of Heavy-Chain Antibodies

Trends in immunology, 2018-12, Vol.39 (12), p.956-960

2018

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Structure of a Therapeutic Antibody in Complex with MUC16 Reveals a Conformational Epitope Influenced by Antigen Glycosylation

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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2.1 Å crystal structure of the Mycobacterium tuberculosis serine hydrolase, Hip1, in its anhydro-form (Anhydrohip1)

Biochemical and biophysical research communications, 2022-11, Vol.630, p.57-63

2022

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ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody

Clinical cancer research, 2022-03, Vol.28 (5), p.948-959

2022

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Interrogating the Theranostic Capacity of a MUC16-Targeted Antibody for Ovarian Cancer

Journal of Nuclear Medicine, 2024-04, Vol.65 (4), p.580-585

2024

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Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6

Molecular cancer therapeutics, 2024-06, Vol.23 (6), p.836

2024

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Preclinical Evaluation of a Humanized, Near-Infrared Fluorescent Antibody for Fluorescence-Guided Surgery of MUC16-Expressing Pancreatic Cancer

Molecular pharmaceutics, 2022-10, Vol.19 (10), p.3586-3599

2022

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Untangling structure–function relationships in the rhomboid family of intramembrane proteases

Biochimica et biophysica acta, 2013-12, Vol.1828 (12), p.2862-2872

2013

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Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody–Carbohydrate Binding Affinity by an Order of Magnitude

Biochemistry (Easton), 2019-02, Vol.58 (6), p.714-726

2019

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Rapid expression screening of eukaryotic membrane proteins in Pichia pastoris

Protein science, 2013-04, Vol.22 (4), p.425-433

2013

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Role of glycosylation on the ensemble of conformations in the MUC1 immunodominant epitope

Journal of peptide science, 2020-01, Vol.26 (1), p.e3229-n/a

2020

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The structure of lactoferrin-binding protein B from Neisseria meningitidis suggests roles in iron acquisition and neutralization of host defences

Acta crystallographica. Section F, Structural biology communications, 2014-10, Vol.70 (10), p.1312-1317

2014

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Structural basis of VHH-mediated neutralization of the food-borne pathogen Listeria monocytogenes

Glycosylation of MUC1 influences the binding of a therapeutic antibody by altering the conformational equilibrium of the antigen

Role of a noncanonical disulfide bond in the stability, affinity, and flexibility of a VHH specific for the Listeria virulence factor InlB

Structure of a VHH isolated from a naïve phage display library

Antibody recognition of a unique tumor-specific glycopeptide antigen

Crystal structure of a human MUC16 SEA domain reveals insight into the nature of the CA125 tumor marker

Antibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPS

Experimental Determination of Antibody Affinity and Avidity: Guidance and Considerations

Charting the Course for Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

Directed Evolution of the Escherichia coli cAMP Receptor Protein at the cAMP Pocket

Understanding the Role of Cancer Glycosylation on Antibody Binding to MUC16

Modular Cloning of MUC1 Recombinant Antibodies by Assembly of Synthetic Domain Genes

X-ray Crystal Structure Analysis of VHH-Protein Antigen Complexes

Immunological Functions and Evolutionary Emergence of Heavy-Chain Antibodies

Structure of a Therapeutic Antibody in Complex with MUC16 Reveals a Conformational Epitope Influenced by Antigen Glycosylation

2.1 Å crystal structure of the Mycobacterium tuberculosis serine hydrolase, Hip1, in its anhydro-form (Anhydrohip1)

ImmunoPET of Ovarian and Pancreatic Cancer with AR9.6, a Novel MUC16-Targeted Therapeutic Antibody

Interrogating the Theranostic Capacity of a MUC16-Targeted Antibody for Ovarian Cancer

Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6

Preclinical Evaluation of a Humanized, Near-Infrared Fluorescent Antibody for Fluorescence-Guided Surgery of MUC16-Expressing Pancreatic Cancer

Untangling structure–function relationships in the rhomboid family of intramembrane proteases

Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody–Carbohydrate Binding Affinity by an Order of Magnitude

Rapid expression screening of eukaryotic membrane proteins in Pichia pastoris

Role of glycosylation on the ensemble of conformations in the MUC1 immunodominant epitope

The structure of lactoferrin-binding protein B from Neisseria meningitidis suggests roles in iron acquisition and neutralization of host defences

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