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Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?

Lancet neurology, 2014-11, Vol.13 (11), p.1127-1138

2014

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Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

Nature (London), 2011-09, Vol.477 (7363), p.211-215

2011

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A randomized controlled trial of resistance and endurance exercise in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis and frontotemporal degeneration, 2018-04, Vol.19 (3-4), p.250-258

2018

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Supported Treadmill Ambulation for Amyotrophic Lateral Sclerosis: A Pilot Study

Archives of physical medicine and rehabilitation, 2010-12, Vol.91 (12), p.1920-1929

2010

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A post hoc analysis of subgroup outcomes and creatinine in the phase III clinical trial (EMPOWER) of dexpramipexole in ALS

Amyotrophic lateral sclerosis and frontotemporal degeneration, 2014-09, Vol.15 (5-6), p.406-413

2014

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Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway

BMC medical genomics, 2011-10, Vol.4 (1), p.74-74, Article 74

2011

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The LO-BaFL method and ALS microarray expression analysis

BMC bioinformatics, 2012-09, Vol.13 (1), p.244-244, Article 244

2012

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Defining and diagnosing involuntary emotional expression disorder

CNS spectrums, 2006-06, Vol.11 (S6), p.1

2006

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A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS

Amyotrophic lateral sclerosis and frontotemporal degeneration, 2021-05, Vol.22 (3-4), p.287-299

2021

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Metabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology

American journal of physiology. Regulatory, integrative and comparative physiology, 2011-04, Vol.300 (4), p.R844-R854

2011

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Best practices protocol for the evaluation of bulbar dysfunction: summary recommendations from the NEALS bulbar subcommittee symposium

Amyotrophic lateral sclerosis and frontotemporal degeneration, 2018-05, Vol.19 (3-4), p.311-312

2018

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In Vitro Effects of Cholesterol β-d-Glucoside, Cholesterol and Cycad Phytosterol Glucosides on Respiration and Reactive Oxygen Species Generation in Brain Mitochondria

The Journal of membrane biology, 2010-10, Vol.237 (2-3), p.71-77

2010

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Consensus guidelines for the design and implementation of clinical trials in ALS

Journal of the neurological sciences, 1999-10, Vol.169 (1), p.2-12

1999

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A longitudinal study of motor performance and striatal [18F]fluorodopa uptake in Parkinson’s disease

Brain imaging and behavior, 2011-09, Vol.5 (3), p.203-211

2011

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Myopathic dropped head syndrome: an expanding clinicopathological spectrum

American journal of physical medicine & rehabilitation, 2007-12, Vol.86 (12), p.970

2007

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Multiple orofacial indices in amyotrophic lateral sclerosis

Journal of speech and hearing research, 1993-12, Vol.36 (6), p.1158

1993

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The Six-Minute Walk (6MWT) as a measure Walking capacity (WC) in Ambulatory Individual with Amyotrophic Lateral Sclerosis (ambALS)

Archives of physical medicine and rehabilitation, 2017

2017

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CuZnSOD and MnSOD immunoreactivity in brain stem motor neurons from amyotropic lateral sclerosis patients

Acta neuropathologica, 1997-12, Vol.95 (1), p.63-70

1997

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Quantitative description of the dysarthria in women with amyotrophic lateral sclerosis

Journal of speech and hearing research, 1992-08, Vol.35 (4), p.723

1992

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In Vitro Effects of Cholesterol [beta]-d-Glucoside, Cholesterol and Cycad Phytosterol Glucosides on Respiration and Reactive Oxygen Species Generation in Brain Mitochondria

The Journal of membrane biology, 2010-10, Vol.237 (2-3), p.71

2010

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Speech deterioration in amyotrophic lateral sclerosis: a case study

Journal of speech and hearing research, 1991-12, Vol.34 (6), p.1269

1991

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Metabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology

American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Vol.69 (4)

2011

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Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials

Amyotrophic lateral sclerosis, 2004-06, Vol.5 (2), p.107-117

2004

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Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?

Controversies and priorities in amyotrophic lateral sclerosis

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

A randomized controlled trial of resistance and endurance exercise in amyotrophic lateral sclerosis

Supported Treadmill Ambulation for Amyotrophic Lateral Sclerosis: A Pilot Study

A post hoc analysis of subgroup outcomes and creatinine in the phase III clinical trial (EMPOWER) of dexpramipexole in ALS

Microarray analysis of peripheral blood lymphocytes from ALS patients and the SAFE detection of the KEGG ALS pathway

The LO-BaFL method and ALS microarray expression analysis

Defining and diagnosing involuntary emotional expression disorder

A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS

Metabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology

Best practices protocol for the evaluation of bulbar dysfunction: summary recommendations from the NEALS bulbar subcommittee symposium

In Vitro Effects of Cholesterol β-d-Glucoside, Cholesterol and Cycad Phytosterol Glucosides on Respiration and Reactive Oxygen Species Generation in Brain Mitochondria

Consensus guidelines for the design and implementation of clinical trials in ALS

A longitudinal study of motor performance and striatal [18F]fluorodopa uptake in Parkinson’s disease

Myopathic dropped head syndrome: an expanding clinicopathological spectrum

Multiple orofacial indices in amyotrophic lateral sclerosis

The Six-Minute Walk (6MWT) as a measure Walking capacity (WC) in Ambulatory Individual with Amyotrophic Lateral Sclerosis (ambALS)

CuZnSOD and MnSOD immunoreactivity in brain stem motor neurons from amyotropic lateral sclerosis patients

Quantitative description of the dysarthria in women with amyotrophic lateral sclerosis

In Vitro Effects of Cholesterol [beta]-d-Glucoside, Cholesterol and Cycad Phytosterol Glucosides on Respiration and Reactive Oxygen Species Generation in Brain Mitochondria

Speech deterioration in amyotrophic lateral sclerosis: a case study

Metabolic and functional differences between brain and spinal cord mitochondria underlie different predisposition to pathology

Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials

Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery

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