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Cathepsin K inhibitors for osteoporosis and potential off-target effects

Expert opinion on investigational drugs, 2009-05, Vol.18 (5), p.585-600

2009

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Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases

Matrix biology, 2018-01, Vol.65, p.30-44

2018

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Tanshinones that selectively block the collagenase activity of cathepsin K provide a novel class of ectosteric antiresorptive agents for bone

British journal of pharmacology, 2018-03, Vol.175 (6), p.902-923

2018

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Human and Parasitic Papain-Like Cysteine Proteases: Their Role in Physiology and Pathology and Recent Developments in Inhibitor Design

Chemical reviews, 2002-12, Vol.102 (12), p.4459-4488

2002

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Characterization of cathepsin S exosites that govern its elastolytic activity

Biochemical journal, 2020-01, Vol.477 (1), p.227-242

2020

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An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice

Journal of bone and mineral research, 2017-12, Vol.32 (12), p.2415-2430

2017

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Elastolytic activity of cysteine cathepsins K, S, and V promotes vascular calcification

Scientific reports, 2019-07, Vol.9 (1), p.9682-13, Article 9682

2019

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Diabetes Perturbs Bone Microarchitecture and Bone Strength through Regulation of Sema3A/IGF-1/β-Catenin in Rats

Cellular physiology and biochemistry, 2017-01, Vol.41 (1), p.55-66

2017

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An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice

Journal of bone and mineral research, 2019-04, Vol.34 (4), p.777-778

2019

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Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K

Circulation research, 2009-02, Vol.104 (4), p.455-465

2009

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Thiol-dependent cathepsins: pathophysiological implications and recent advances in inhibitor design

Current pharmaceutical design, 2002-01, Vol.8 (18), p.1639-1658

2002

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ApoE-Deficient Mice on Cholate-Containing High-Fat Diet Reveal a Pathology Similar to Lung Sarcoidosis

The American journal of pathology, 2010-03, Vol.176 (3), p.1148-1156

2010

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Osteoclastic Bone Degradation and the Role of Different Cysteine Proteinases and Matrix Metalloproteinases: Differences Between Calvaria and Long Bone

Journal of bone and mineral research, 2006-09, Vol.21 (9), p.1399-1408

2006

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The S2 subsites of cathepsins K and L and their contribution to collagen degradation

Protein science, 2007-04, Vol.16 (4), p.662-670

2007

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The role of cathepsins in osteoporosis and arthritis: Rationale for the design of new therapeutics

Advanced drug delivery reviews, 2005-05, Vol.57 (7), p.973-993

2005

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Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice

Aging (Albany, NY.), 2019-11, Vol.11 (21), p.9348-9368

2019

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Cathepsin K Is the Principal Protease in Giant Cell Tumor of Bone

The American journal of pathology, 2004-08, Vol.165 (2), p.593-600

2004

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Cathepsin K Activity-dependent Regulation of Osteoclast Actin Ring Formation and Bone Resorption

The Journal of biological chemistry, 2009-01, Vol.284 (4), p.2584-2592

2009

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Collagen type I degradation fragments act through the collagen receptor LAIR-1 to provide a negative feedback for osteoclast formation

Bone (New York, N.Y.), 2018-12, Vol.117, p.23-30

2018

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Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S

Biological chemistry, 2007-03, Vol.388 (3), p.331-336

2007

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Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities

The Journal of biological chemistry, 2006-05, Vol.281 (18), p.12824-12832

2006

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Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages

The Journal of experimental medicine, 2000-04, Vol.191 (7), p.1177-1186

2000

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Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation

Biochimica et biophysica acta. General subjects, 2020-05, Vol.1864 (5), p.129544-129544, Article 129544

2020

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Evaluation of Decalcification Techniques for Rat Femurs Using HE and Immunohistochemical Staining

BioMed research international, 2017-01, Vol.2017 (2017), p.1-6

2017

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Cathepsin K inhibitors for osteoporosis and potential off-target effects

Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases

Tanshinones that selectively block the collagenase activity of cathepsin K provide a novel class of ectosteric antiresorptive agents for bone

Human and Parasitic Papain-Like Cysteine Proteases: Their Role in Physiology and Pathology and Recent Developments in Inhibitor Design

Characterization of cathepsin S exosites that govern its elastolytic activity

An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice

Elastolytic activity of cysteine cathepsins K, S, and V promotes vascular calcification

Diabetes Perturbs Bone Microarchitecture and Bone Strength through Regulation of Sema3A/IGF-1/β-Catenin in Rats

An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice

Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K

Thiol-dependent cathepsins: pathophysiological implications and recent advances in inhibitor design

ApoE-Deficient Mice on Cholate-Containing High-Fat Diet Reveal a Pathology Similar to Lung Sarcoidosis

Osteoclastic Bone Degradation and the Role of Different Cysteine Proteinases and Matrix Metalloproteinases: Differences Between Calvaria and Long Bone

The S2 subsites of cathepsins K and L and their contribution to collagen degradation

Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3-dependent sensitization

The role of cathepsins in osteoporosis and arthritis: Rationale for the design of new therapeutics

Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice

Cathepsin K Is the Principal Protease in Giant Cell Tumor of Bone

Cathepsin K Activity-dependent Regulation of Osteoclast Actin Ring Formation and Bone Resorption

Collagen type I degradation fragments act through the collagen receptor LAIR-1 to provide a negative feedback for osteoclast formation

Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S

Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities

Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages

Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation

Evaluation of Decalcification Techniques for Rat Femurs Using HE and Immunohistochemical Staining

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