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Heat Shock Protein Inhibitors: Success Stories

1st ed. 2016., 2016

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Molecular chaperones and substrate ubiquitination control the efficiency of endoplasmic reticulum-associated degradation

Diabetes, obesity & metabolism, 2010-10, Vol.12 (s2), p.32-38

2010

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Heat shock protein 101 effects in A. thaliana: genetic variation, fitness and pleiotropy in controlled temperature conditions

Molecular ecology, 2008-03, Vol.17 (6), p.1614-1626

2008

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THE ACTION OF MOLECULAR CHAPERONES IN THE EARLY SECRETORY PATHWAY

Annual review of genetics, 2001-01, Vol.35 (1), p.149-191

2001

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Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast

Molecular biology of the cell, 2001-05, Vol.12 (5), p.1303-1314

2001

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A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome

The Journal of cell biology, 1993-12, Vol.123 (6), p.1355-1363

1993

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Differential regulation of MAP2 by phosphorylation events in proline‐rich versus C‐terminal domains

The FASEB journal, 2023-10, Vol.37 (10), p.e23194-n/a

2023

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Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP

The Journal of cell biology, 1996-02, Vol.132 (3), p.291-298

1996

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BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum

Proceedings of the National Academy of Sciences - PNAS, 1995-10, Vol.92 (21), p.9643-9646

1995

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The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain

Molecular and Cellular Biology, 1997-08, Vol.17 (8), p.4761-4773

1997

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Selectivity of the molecular chaperone-specific immunosuppressive agent 15-deoxyspergualin: Modulation of HSC70 ATPase activity without compromising DnaJ chaperone interactions

Biochemical pharmacology, 1999-04, Vol.57 (8), p.877-880

Brodsky, Jeffrey L

1999

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Regulation of Hsp70 Function by HspBP1: Structural Analysis Reveals an Alternate Mechanism for Hsp70 Nucleotide Exchange

Molecular cell, 2005-02, Vol.17 (3), p.367-379

2005

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Molecular Chaperones in the Yeast Endoplasmic Reticulum Maintain the Solubility of Proteins for Retrotranslocation and Degradation

The Journal of cell biology, 2001-05, Vol.153 (5), p.1061-1069

2001

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ER protein quality control and proteasome-mediated protein degradation

Seminars in cell & developmental biology, 1999-10, Vol.10 (5), p.507-513

1999

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Nucleotide Exchange Factor for the Yeast Hsp70 Molecular Chaperone Ssa1p

Molecular and Cellular Biology, 2002-07, Vol.22 (13), p.4677-4689

2002

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Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic Hsc70

The Journal of cell biology, 1993, Vol.120 (1), p.95-102

1993

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The Function of the Yeast Molecular Chaperone Sse1 Is Mechanistically Distinct from the Closely Related Hsp70 Family

The Journal of biological chemistry, 2004-05, Vol.279 (21), p.21992-22001

2004

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Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate

Proceedings of the National Academy of Sciences - PNAS, 1996-11, Vol.93 (24), p.13797-13801

1996

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The Requirement for Molecular Chaperones during Endoplasmic Reticulum-associated Protein Degradation Demonstrates That Protein Export and Import Are Mechanistically Distinct

The Journal of biological chemistry, 1999-02, Vol.274 (6), p.3453-3460

1999

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Apoprotein B Degradation Is Promoted by the Molecular Chaperones hsp90 and hsp70

The Journal of biological chemistry, 2001-07, Vol.276 (27), p.24891-24900

2001

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Degradation of Mutated Bovine Pancreatic Trypsin Inhibitor in the Yeast Vacuole Suggests Post-endoplasmic Reticulum Protein Quality Control

The Journal of biological chemistry, 2004-04, Vol.279 (15), p.15289-15297

2004

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A J Domain Virulence Effector of Pseudomonas syringae Remodels Host Chloroplasts and Suppresses Defenses

Current biology, 2007-03, Vol.17 (6), p.499-508

2007

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Sodium affinity of brain Na(+)-K(+)-ATPase is dependent on isozyme and environment of the pump

American Journal of Physiology: Cell Physiology, 1990-05, Vol.258 (5), p.C803-C811

1990

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Insulin activation of brain Na(+)-K(+)-ATPase is mediated by alpha 2-form of enzyme

American Journal of Physiology: Cell Physiology, 1990-05, Vol.258 (5), p.C812-C817

Brodsky, J. L

1990

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Small molecule microarrays: from proteins to mammalian cells – are we there yet?

Trends in biotechnology (Regular ed.), 2005-06, Vol.23 (6), p.271-274

2005

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Heat Shock Protein Inhibitors: Success Stories

Molecular chaperones and substrate ubiquitination control the efficiency of endoplasmic reticulum-associated degradation

Heat shock protein 101 effects in A. thaliana: genetic variation, fitness and pleiotropy in controlled temperature conditions

THE ACTION OF MOLECULAR CHAPERONES IN THE EARLY SECRETORY PATHWAY

Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast

A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome

Differential regulation of MAP2 by phosphorylation events in proline‐rich versus C‐terminal domains

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP

BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum

The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain

Selectivity of the molecular chaperone-specific immunosuppressive agent 15-deoxyspergualin: Modulation of HSC70 ATPase activity without compromising DnaJ chaperone interactions

Regulation of Hsp70 Function by HspBP1: Structural Analysis Reveals an Alternate Mechanism for Hsp70 Nucleotide Exchange

Molecular Chaperones in the Yeast Endoplasmic Reticulum Maintain the Solubility of Proteins for Retrotranslocation and Degradation

ER protein quality control and proteasome-mediated protein degradation

Nucleotide Exchange Factor for the Yeast Hsp70 Molecular Chaperone Ssa1p

Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic Hsc70

The Function of the Yeast Molecular Chaperone Sse1 Is Mechanistically Distinct from the Closely Related Hsp70 Family

Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate

The Requirement for Molecular Chaperones during Endoplasmic Reticulum-associated Protein Degradation Demonstrates That Protein Export and Import Are Mechanistically Distinct

Apoprotein B Degradation Is Promoted by the Molecular Chaperones hsp90 and hsp70

Degradation of Mutated Bovine Pancreatic Trypsin Inhibitor in the Yeast Vacuole Suggests Post-endoplasmic Reticulum Protein Quality Control

A J Domain Virulence Effector of Pseudomonas syringae Remodels Host Chloroplasts and Suppresses Defenses

Sodium affinity of brain Na(+)-K(+)-ATPase is dependent on isozyme and environment of the pump

Insulin activation of brain Na(+)-K(+)-ATPase is mediated by alpha 2-form of enzyme

Small molecule microarrays: from proteins to mammalian cells – are we there yet?

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