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Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens: Synthesis, in Vitro Biological Activity, Pharmacokinetics, and Antitumor Activity in the LAPC4 Human Prostate Cancer Xenograft Model

Journal of medicinal chemistry, 2005-04, Vol.48 (8), p.2972-2984

2005

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Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole

Cancer research (Chicago, Ill.), 2005-06, Vol.65 (12), p.5380-5389

2005

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Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model

Cancer research (Chicago, Ill.), 2005-06, Vol.65 (12), p.5439-5444

2005

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Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR

British journal of cancer, 2010-09, Vol.103 (7), p.1001-1007

2010

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Abstract PD05-03: HDAC Inhibitor Entinostat Restores Responsiveness of Letrozole Resistant MCF-7Ca Xenografts to AIs through Modulation of Her-2

Cancer research (Chicago, Ill.), 2010-12, Vol.70 (24_Supplement), p.PD05-03-PD05-03

2010

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The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts

The Prostate, 2004-03, Vol.58 (4), p.382-393

2004

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Three Dimensional Pharmacophore Modeling of Human CYP17 Inhibitors. Potential Agents for Prostate Cancer Therapy

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2345-2351

2003

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Inhibitors of 17α-Hydroxylase/17,20-Lyase (CYPl7): Potential Agents for the Treatment of Prostate Cancer

Current pharmaceutical design, 1999-03, Vol.5 (3), p.163-180

1999

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Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice

British journal of cancer, 2006-02, Vol.94 (4), p.513-523

2006

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Aromatase and COX-2 expression in human breast cancers

Journal of steroid biochemistry and molecular biology, 2001-12, Vol.79 (1), p.41-47

2001

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Novel Retinoic Acid Metabolism Blocking Agents Endowed with Multiple Biological Activities Are Efficient Growth Inhibitors of Human Breast and Prostate Cancer Cells in Vitro and a Human Breast Tumor Xenograft in Nude Mice

Journal of medicinal chemistry, 2004-12, Vol.47 (27), p.6716-6729

2004

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Aromatase inhibitors and their application in breast cancer treatment

Steroids, 2000-04, Vol.65 (4), p.171-179

2000

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Comprehensive pharmacology and clinical efficacy of aromatase inhibitors

Drugs (New York, N.Y.), 1999-08, Vol.58 (2), p.233-255

1999

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Novel P450(17alpha) inhibitors: 17-(2'-oxazolyl)- and 17-(2'-thiazolyl)-androstene derivatives

Steroids, 2003-09, Vol.68 (7-8), p.603-611

2003

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Intracellular aromatase and its relevance to the pharmacological efficacy of aromatase inhibitors

Journal of steroid biochemistry and molecular biology, 2001-01, Vol.76 (1), p.199-202

2001

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Effects of Exemestane and Tamoxifen in a Postmenopausal Breast Cancer Model

Clinical cancer research, 2004-11, Vol.10 (21), p.7375-7381

2004

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Aromatase inhibitors and breast cancer

Seminars in oncology, 1996-08, Vol.23 (4 Suppl 9), p.10-20

1996

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Aromatase inhibitors in advanced breast cancer: mechanism of action and clinical implications

Journal of Steroid Biochemistry and Molecular Biology, 1998-07, Vol.66 (1), p.1-10

1998

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Aromatase inhibitors in the treatment of breast cancer

Journal of steroid biochemistry and molecular biology, 1994-06, Vol.49 (4), p.281-287

Brodie, Angela M.H.

1994

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Potent CYP17 inhibitors: improved syntheses, pharmacokinetics and anti-tumor activity in the LNCaP human prostate cancer model

The Journal of steroid biochemistry and molecular biology, 2004-10, Vol.92 (3), p.155-165

2004

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The steroidal antiestrogen ICI 182,780 is an inhibitor of cellular aromatase activity

The Journal of steroid biochemistry and molecular biology, 1998-11, Vol.67 (4), p.293-304

1998

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Mechanisms of the actions of aromatase inhibitors 4-hydroxyandrostenedione, fadrozole, and aminoglutethimide on aromatase in JEG-3 cell culture

The Journal of steroid biochemistry and molecular biology, 1997-11, Vol.63 (4), p.317-328

1997

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Aromatase, its inhibitors and their use in breast cancer treatment

Pharmacology & therapeutics (Oxford), 1993-12, Vol.60 (3), p.501-515

BRODIE, A. M. H

1993

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Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids

Bioorganic & medicinal chemistry letters, 2000-09, Vol.10 (17), p.1905-1908

2000

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Expression of aromatase cytochrome P-450 in premenopausal and postmenopausal human ovaries: an immunocytochemical study

The journal of clinical endocrinology and metabolism, 1991-10, Vol.73 (4), p.717-726

1991

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Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens: Synthesis, in Vitro Biological Activity, Pharmacokinetics, and Antitumor Activity in the LAPC4 Human Prostate Cancer Xenograft Model

Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole

Additive antitumor effect of aromatase inhibitor letrozole and antiestrogen fulvestrant in a postmenopausal breast cancer model

Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR

Abstract PD05-03: HDAC Inhibitor Entinostat Restores Responsiveness of Letrozole Resistant MCF-7Ca Xenografts to AIs through Modulation of Her-2

The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts

Three Dimensional Pharmacophore Modeling of Human CYP17 Inhibitors. Potential Agents for Prostate Cancer Therapy

Inhibitors of 17α-Hydroxylase/17,20-Lyase (CYPl7): Potential Agents for the Treatment of Prostate Cancer

Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice

Aromatase and COX-2 expression in human breast cancers

Novel Retinoic Acid Metabolism Blocking Agents Endowed with Multiple Biological Activities Are Efficient Growth Inhibitors of Human Breast and Prostate Cancer Cells in Vitro and a Human Breast Tumor Xenograft in Nude Mice

Aromatase inhibitors and their application in breast cancer treatment

Comprehensive pharmacology and clinical efficacy of aromatase inhibitors

Novel P450(17alpha) inhibitors: 17-(2'-oxazolyl)- and 17-(2'-thiazolyl)-androstene derivatives

Intracellular aromatase and its relevance to the pharmacological efficacy of aromatase inhibitors

Effects of Exemestane and Tamoxifen in a Postmenopausal Breast Cancer Model

Aromatase inhibitors and breast cancer

Aromatase inhibitors in advanced breast cancer: mechanism of action and clinical implications

Aromatase inhibitors in the treatment of breast cancer

Potent CYP17 inhibitors: improved syntheses, pharmacokinetics and anti-tumor activity in the LNCaP human prostate cancer model

The steroidal antiestrogen ICI 182,780 is an inhibitor of cellular aromatase activity

Mechanisms of the actions of aromatase inhibitors 4-hydroxyandrostenedione, fadrozole, and aminoglutethimide on aromatase in JEG-3 cell culture

Aromatase, its inhibitors and their use in breast cancer treatment

Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids

Expression of aromatase cytochrome P-450 in premenopausal and postmenopausal human ovaries: an immunocytochemical study

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