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Chemical biology of mGlu4 receptor activation: dogmas, challenges, strategies and opportunities

Current topics in medicinal chemistry, 2014-01, Vol.14 (15), p.1755-1770

2014

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Discovery and structure–activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1398-1406

2013

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P2X7 receptor‐mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats

European journal of pain, 2022-07, Vol.26 (6), p.1304-1321

2022

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Identification and characterization of NDT 9513727 [N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a novel, orally bioavailable C5a receptor inverse agonist

The Journal of pharmacology and experimental therapeutics, 2008-12, Vol.327 (3), p.898-909

2008

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Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation

The Annals of thoracic surgery, 2007, Vol.83 (1), p.146-152

2007

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C5L2, a Nonsignaling C5A Binding Protein

Biochemistry (Easton), 2003-08, Vol.42 (31), p.9406-9415

2003

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Molecular Characterization of the Gerbil C5a Receptor and Identification of a Transmembrane Domain V Amino Acid That Is Crucial for Small Molecule Antagonist Interaction

The Journal of biological chemistry, 2005-12, Vol.280 (49), p.40617-40623

2005

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Efficacy switching SAR of mGluR5 allosteric modulators: Highly potent positive and negative modulators from one chemotype

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (11), p.3407-3410

2011

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Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (12), p.3275-3278

2009

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Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (14), p.4037-4043

2013

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N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (17), p.5658-5662

2012

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Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2012-10, Vol.22 (20), p.6469-6474

2012

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Novel heterocyclic compounds as mGlu5 antagonists: WO2009015897

Expert opinion on therapeutic patents, 2010-03, Vol.20 (3), p.435-439

2010

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Aminopyrazine CB1 receptor inverse agonists

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (11), p.3376-3381

2008

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Discovery of a potent and brain penetrant mGluRS positive allosteric modulator

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (12), p.3275-3278

2009

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Leukocyte effects of C5a-receptor blockade during simulated extracorporeal circulation. Commentary

The Annals of thoracic surgery, 2007, Vol.83 (1), p.146-152

2007

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Circulatory Half-Life but not Interaction with the Lutropin/Chorionic Gonadotropin Receptor is Modulated by Sulfation of Bovine Lutropin Oligosaccharides

Proceedings of the National Academy of Sciences - PNAS, 1992-01, Vol.89 (1), p.334-338

1992

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Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction. VOLUME 280 (2005) PAGES 40617-40623

The Journal of biological chemistry, 2006-02, Vol.281 (6), p.3752-3752

2006

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Secretion of alpha-1-proteinase inhibitor requires an almost full length molecule

The Journal of biological chemistry, 1992-01, Vol.267 (1), p.294-297

1992

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Study of the roles of proline 391 and a highly conserved sequence in the carboxyl-terminal region of members of the serpin family in the secretion of α1-proteinase inhibitor

The Journal of biological chemistry, 1994-06, Vol.269 (25), p.17252-17256

1994

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Residue 78 in the second transmembrane domain of the neurokinin-1 receptor is important in coupling high affinity agonist binding to multiple second messenger responses

Molecular pharmacology, 1995-05, Vol.47 (5), p.1065

1995

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G-Protein Coupled Receptor Inverse Agonists: Identification, Pharmacological Relevance and Functional Assays

Annual Reports in Medicinal Chemistry, 2005, Vol.40, p.373-386

2005

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Lectin affinity high-performance liquid chromatography: Interactions of N-glycanase-released oligosaccharides with leukoagglutinating phytohemagglutinin, concanavalin A, Datura stramonium agglutinin, and Vicia villosa agglutinin

Analytical biochemistry, 1987-11, Vol.167 (1), p.62-75

1987

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Design and Synthesis of [(2,3-Dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as Novel Ligands Selective for the Dopamine D3 Receptor Subtype

Journal of medicinal chemistry, 2001-09, Vol.44 (19), p.3175-3186

2001

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Design and Synthesis of [(2,3-Dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as Novel Ligands Selective for the Dopamine D 3 Receptor Subtype

Journal of medicinal chemistry, 2001-09, Vol.44 (19), p.3175-3186

2001

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Chemical biology of mGlu4 receptor activation: dogmas, challenges, strategies and opportunities

Discovery and structure–activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators

P2X7 receptor‐mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats

Identification and characterization of NDT 9513727 [N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a novel, orally bioavailable C5a receptor inverse agonist

Leukocyte Effects of C5a-Receptor Blockade During Simulated Extracorporeal Circulation

C5L2, a Nonsignaling C5A Binding Protein

Molecular Characterization of the Gerbil C5a Receptor and Identification of a Transmembrane Domain V Amino Acid That Is Crucial for Small Molecule Antagonist Interaction

Efficacy switching SAR of mGluR5 allosteric modulators: Highly potent positive and negative modulators from one chemotype

Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator

Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators

N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators

Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators

Novel heterocyclic compounds as mGlu5 antagonists: WO2009015897

Aminopyrazine CB1 receptor inverse agonists

Discovery of a potent and brain penetrant mGluRS positive allosteric modulator

Leukocyte effects of C5a-receptor blockade during simulated extracorporeal circulation. Commentary

Circulatory Half-Life but not Interaction with the Lutropin/Chorionic Gonadotropin Receptor is Modulated by Sulfation of Bovine Lutropin Oligosaccharides

Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction. VOLUME 280 (2005) PAGES 40617-40623

Secretion of alpha-1-proteinase inhibitor requires an almost full length molecule

Study of the roles of proline 391 and a highly conserved sequence in the carboxyl-terminal region of members of the serpin family in the secretion of α1-proteinase inhibitor

Residue 78 in the second transmembrane domain of the neurokinin-1 receptor is important in coupling high affinity agonist binding to multiple second messenger responses

G-Protein Coupled Receptor Inverse Agonists: Identification, Pharmacological Relevance and Functional Assays

Lectin affinity high-performance liquid chromatography: Interactions of N-glycanase-released oligosaccharides with leukoagglutinating phytohemagglutinin, concanavalin A, Datura stramonium agglutinin, and Vicia villosa agglutinin

Design and Synthesis of [(2,3-Dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as Novel Ligands Selective for the Dopamine D3 Receptor Subtype

Design and Synthesis of [(2,3-Dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as Novel Ligands Selective for the Dopamine D 3 Receptor Subtype

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