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A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction

Clinical cancer research, 2012-02, Vol.18 (3), p.858-868

2012

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Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes

The Journal of experimental medicine, 2004-08, Vol.200 (4), p.527-533

2004

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Clinical Development of Listeria monocytogenes –Based Immunotherapies

Seminars in oncology, 2012-06, Vol.39 (3), p.311-322

2012

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Listeria-Based Cancer Vaccines That Segregate Immunogenicity from Toxicity

Proceedings of the National Academy of Sciences - PNAS, 2004-09, Vol.101 (38), p.13832-13837

2004

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Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

Immunity (Cambridge, Mass.), 2016-08, Vol.45 (2), p.389-401

2016

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Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer

Journal of clinical oncology, 2015-04, Vol.33 (12), p.1325-1333

2015

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Results from a Phase IIb, Randomized, Multicenter Study of GVAX Pancreas and CRS-207 Compared with Chemotherapy in Adults with Previously Treated Metastatic Pancreatic Adenocarcinoma (ECLIPSE Study)

Clinical cancer research, 2019-09, Vol.25 (18), p.5493-5502

2019

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Enhanced virus-specific CD8+ T cell responses by Listeria monocytogenes-infected dendritic cells in the context of Tim-3 blockade

PloS one, 2014, Vol.9 (1), p.e87821-e87821

2014

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Clinical Response of Live-Attenuated, Listeria monocytogenes Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma

Clinical cancer research, 2019-10, Vol.25 (19), p.5787-5798

2019

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Impact of Preexisting Vector-Specific Immunity on Vaccine Potency: Characterization of Listeria monocytogenes-Specific Humoral and Cellular Immunity in Humans and Modeling Studies Using Recombinant Vaccines in Mice

Infection and Immunity, 2009-09, Vol.77 (9), p.3958-3968

2009

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Evaluation of Cyclophosphamide/GVAX Pancreas Followed by Listeria-Mesothelin (CRS-207) with or without Nivolumab in Patients with Pancreatic Cancer

Clinical cancer research, 2020-07, Vol.26 (14), p.3578-3588

2020

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Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains

Infection and Immunity, 2008-08, Vol.76 (8), p.3742-3753

2008

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Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria

PLoS pathogens, 2009-09, Vol.5 (9), p.e1000568-e1000568

2009

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Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity

Journal of medicinal chemistry, 2020-05, Vol.63 (10), p.5398-5420

2020

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A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice

Gastroenterology (New York, N.Y. 1943), 2014-06, Vol.146 (7), p.1784-1794.e6

2014

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Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study

Allergy (Copenhagen), 2024-04, Vol.79 (4), p.924-936

2024

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Cytosolic Entry Controls CD8⁺-T-Cell Potency during Bacterial Infection

Infection and Immunity, 2006-11, Vol.74 (11), p.6387-6397

2006

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Tumors establish resistance to immunotherapy by regulating T reg recruitment via CCR4

Journal for immunotherapy of cancer, 2020-11, Vol.8 (2), p.e000764

2020

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Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8584-8607

2020

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Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo

Molecular cancer therapeutics, 2020-10, Vol.19 (10), p.1970-1980

2020

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Systemic Tolerance Mediated by Melanoma Brain Tumors Is Reversible by Radiotherapy and Vaccination

Clinical cancer research, 2016-03, Vol.22 (5), p.1161-1172

2016

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A Potent and Effective Suicidal Listeria Vaccine Platform

Infection and immunity, 2019-08, Vol.87 (8)

2019

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EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22

PLoS pathogens, 2022-01, Vol.18 (1), p.e1010200-e1010200

2022

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Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy

Journal of medicinal chemistry, 2022-10, Vol.65 (19), p.12895-12924

2022

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Single-Cell Immune Competency Signatures Associate with Survival in Phase II GVAX and CRS-207 Randomized Studies in Patients with Metastatic Pancreatic Cancer

Cancer immunology research, 2020-05, Vol.8 (5), p.609-617

2020

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A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction

Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes

Clinical Development of Listeria monocytogenes –Based Immunotherapies

Listeria-Based Cancer Vaccines That Segregate Immunogenicity from Toxicity

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer

Results from a Phase IIb, Randomized, Multicenter Study of GVAX Pancreas and CRS-207 Compared with Chemotherapy in Adults with Previously Treated Metastatic Pancreatic Adenocarcinoma (ECLIPSE Study)

Enhanced virus-specific CD8+ T cell responses by Listeria monocytogenes-infected dendritic cells in the context of Tim-3 blockade

Clinical Response of Live-Attenuated, Listeria monocytogenes Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma

Impact of Preexisting Vector-Specific Immunity on Vaccine Potency: Characterization of Listeria monocytogenes-Specific Humoral and Cellular Immunity in Humans and Modeling Studies Using Recombinant Vaccines in Mice

Evaluation of Cyclophosphamide/GVAX Pancreas Followed by Listeria-Mesothelin (CRS-207) with or without Nivolumab in Patients with Pancreatic Cancer

Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains

Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria

Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity

A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice

Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study

Cytosolic Entry Controls CD8⁺-T-Cell Potency during Bacterial Infection

Tumors establish resistance to immunotherapy by regulating T reg recruitment via CCR4

Novel Piperidinyl-Azetidines as Potent and Selective CCR4 Antagonists Elicit Antitumor Response as a Single Agent and in Combination with Checkpoint Inhibitors

Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity In Vitro and In Vivo

Systemic Tolerance Mediated by Melanoma Brain Tumors Is Reversible by Radiotherapy and Vaccination

A Potent and Effective Suicidal Listeria Vaccine Platform

EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22

Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy

Single-Cell Immune Competency Signatures Associate with Survival in Phase II GVAX and CRS-207 Randomized Studies in Patients with Metastatic Pancreatic Cancer

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