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A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair

The Journal of cell biology, 2013-08, Vol.202 (3), p.579-595

2013

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Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

Nature communications, 2016-09, Vol.7 (1), p.12889-12889, Article 12889

2016

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Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

Science (American Association for the Advancement of Science), 2014-05, Vol.344 (6183), p.527-532

2014

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ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks

Nucleic acids research, 2020-09, Vol.48 (17), p.9710-9723

2020

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BRCA1 prevents R-loop-associated centromeric instability

Cell death & disease, 2021-10, Vol.12 (10), p.896-896, Article 896

2021

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DNA Junction Ligands Trigger DNA Damage and Are Synthetic Lethal with DNA Repair Inhibitors in Cancer Cells

Journal of the American Chemical Society, 2020-01, Vol.142 (1), p.424-435

2020

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Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

Cell reports (Cambridge), 2019-09, Vol.28 (12), p.3167-3181.e6

2019

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Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

eLife, 2021-06, Vol.10

2021

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Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

Nature structural & molecular biology, 2010-09, Vol.17 (9), p.1144-1151

2010

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DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal

Nucleic acids research, 2014-08, Vol.42 (14), p.9047

2014

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Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

Nature chemical biology, 2012-02, Vol.8 (3), p.301-310

2012

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DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal

Nucleic acids research, 2014-08, Vol.42 (14), p.9047-9062

2014

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Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites

Cell reports (Cambridge), 2015-05, Vol.11 (5), p.704-714

2015

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Small-molecule-induced DNA damage identifies alternative DNA structures in human genes

Nature chemical biology, 2012-03, Vol.8 (3), p.301

2012

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Phenyl dialkynylcarbinols, a Bioinspired Series of Synthetic Antitumor Acetylenic Lipids

Journal of medicinal chemistry, 2023-10, Vol.66 (20), p.13918-13945

2023

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Identification of the main barriers to Ku accumulation in chromatin

Cell reports (Cambridge), 2024-08, Vol.43 (8), p.114538-114538, Article 114538

2024

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Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells

Nucleic acids research, 2021-10, Vol.49 (18), p.10275-10288

2021

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Identification of Three-Way DNA Junction Ligands through Screening of Chemical Libraries and Validation by Complementary in Vitro Assays

Journal of medicinal chemistry, 2019-05, Vol.62 (9), p.4456-4466

2019

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DNA folds threaten genetic stability and can be leveraged for chemotherapy

RSC chemical biology, 2021-02, Vol.2 (1), p.47-76

2021

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Structural Optimization of Azacryptands for Targeting Three‐Way DNA Junctions

Angewandte Chemie International Edition, 2024-09, Vol.63 (36), p.e202409780-n/a

International ed. in English, 2024

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Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA

European journal of medicinal chemistry, 2023-11, Vol.259, p.115646-115646, Article 115646

2023

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Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis

Molecular and cellular biology, 2015-08, Vol.35 (15), p.2699-2713

2015

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DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks

Nucleic acids research, 2024-02, Vol.52 (3), p.1136-1155

2024

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XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase

Nucleic acids research, 2021-09, Vol.49 (17), p.9906-9925

2021

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A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks

Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks

BRCA1 prevents R-loop-associated centromeric instability

DNA Junction Ligands Trigger DNA Damage and Are Synthetic Lethal with DNA Repair Inhibitors in Cancer Cells

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal

Neddylation Promotes Ubiquitylation and Release of Ku from DNA-Damage Sites

Small-molecule-induced DNA damage identifies alternative DNA structures in human genes

Phenyl dialkynylcarbinols, a Bioinspired Series of Synthetic Antitumor Acetylenic Lipids

Identification of the main barriers to Ku accumulation in chromatin

Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells

Identification of Three-Way DNA Junction Ligands through Screening of Chemical Libraries and Validation by Complementary in Vitro Assays

DNA folds threaten genetic stability and can be leveraged for chemotherapy

Structural Optimization of Azacryptands for Targeting Three‐Way DNA Junctions

SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA

Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis

DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks

XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase

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