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Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC‐derived exosomes

FEBS letters, 2016-12, Vol.590 (23), p.4263-4274

2016

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Extracellular Vesicles in Organ Fibrosis: Mechanisms, Therapies, and Diagnostics

Cells (Basel, Switzerland), 2021-06, Vol.10 (7), p.1596

Brigstock, David R

2021

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Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1

American journal of physiology: Gastrointestinal and liver physiology, 2015-09, Vol.309 (6), p.G491-G499

2015

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Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver

Surgery, 2014-09, Vol.156 (3), p.548-555

2014

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Epigenetic regulation of connective tissue growth factor by MicroRNA‐214 delivery in exosomes from mouse or human hepatic stellate cells

Hepatology (Baltimore, Md.), 2014-03, Vol.59 (3), p.1118-1129

2014

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Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2)

Cytokine & growth factor reviews, 2013-02, Vol.24 (1), p.59-68

2013

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Production, Exacerbating Effect, and EV-Mediated Transcription of Hepatic CCN2 in NASH: Implications for Diagnosis and Therapy of NASH Fibrosis

International journal of molecular sciences, 2023-08, Vol.24 (16), p.12823

2023

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Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals

Journal of cell communication and signaling, 2010-03, Vol.4 (1), p.1-4

Brigstock, David R.

2010

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Therapeutic effects of serum extracellular vesicles in liver fibrosis

Journal of extracellular vesicles, 2018-12, Vol.7 (1), p.1461505-n/a

2018

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Graves' disease overlapping with chronic hepatitis B and methimazole-induced liver injury and autoimmune hepatitis: a case report

BMC gastroenterology, 2022-02, Vol.22 (1), p.59-59, Article 59

2022

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Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61)

Angiogenesis (London), 2002, Vol.5 (3), p.153-165

BRIGSTOCK, David R

2002

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Extracellular Vesicles From Hepatocytes Are Therapeutic for Toxin-Mediated Fibrosis and Gene Expression in the Liver

Frontiers in cell and developmental biology, 2020-01, Vol.7, p.368-368

2020

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Identification of Candidate Angiogenic Inhibitors Processed by Matrix Metalloproteinase 2 (MMP-2) in Cell-Based Proteomic Screens: Disruption of Vascular Endothelial Growth Factor (VEGF)/Heparin Affin Regulatory Peptide (Pleiotrophin) and VEGF/Connective Tissue Growth Factor Angiogenic Inhibitory Complexes by MMP-2 Proteolysis

Molecular and Cellular Biology, 2007-12, Vol.27 (24), p.8454-8465

2007

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Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes

Frontiers in cell and developmental biology, 2021-03, Vol.9, p.640667-640667

2021

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Dynamic Changes in Function and Proteomic Composition of Extracellular Vesicles from Hepatic Stellate Cells during Cellular Activation

Cells (Basel, Switzerland), 2020-01, Vol.9 (2), p.290

2020

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Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo

Journal of cell communication and signaling, 2009-03, Vol.3 (1), p.5-18

Brigstock, David R.

2009

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Regulation of pancreatic inflammation by connective tissue growth factor (CTGF/CCN2)

Immunology, 2014-04, Vol.141 (4), p.564-576

2014

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Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes

Journal of cell communication and signaling, 2014-06, Vol.8 (2), p.147-156

2014

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Regulation of hepatic stellate cells by connective tissue growth factor

Frontiers in bioscience (Landmark. Print), 2012-06, Vol.17 (7), p.2495

2012

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Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes

Hepatology (Baltimore, Md.), 2009-09, Vol.50 (3), p.939-947

2009

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Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis

Laboratory investigation, 2010-08, Vol.90 (8), p.1179-1188

2010

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Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice

Laboratory investigation, 2012-05, Vol.92 (5), p.703-712

2012

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Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor

Journal of hepatology, 2011-08, Vol.55 (2), p.399-406

2011

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Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes

PloS one, 2012-10, Vol.7 (10), p.e46526-e46526

2012

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Fibrogenic Signaling Is Suppressed in Hepatic Stellate Cells through Targeting of Connective Tissue Growth Factor (CCN2) by Cellular or Exosomal MicroRNA-199a-5p

The American journal of pathology, 2016-11, Vol.186 (11), p.2921-2933

2016

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Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC‐derived exosomes

Extracellular Vesicles in Organ Fibrosis: Mechanisms, Therapies, and Diagnostics

Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1

Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver

Epigenetic regulation of connective tissue growth factor by MicroRNA‐214 delivery in exosomes from mouse or human hepatic stellate cells

Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2)

Production, Exacerbating Effect, and EV-Mediated Transcription of Hepatic CCN2 in NASH: Implications for Diagnosis and Therapy of NASH Fibrosis

Connective tissue growth factor (CCN2, CTGF) and organ fibrosis: lessons from transgenic animals

Therapeutic effects of serum extracellular vesicles in liver fibrosis

Graves' disease overlapping with chronic hepatitis B and methimazole-induced liver injury and autoimmune hepatitis: a case report

Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61)

Extracellular Vesicles From Hepatocytes Are Therapeutic for Toxin-Mediated Fibrosis and Gene Expression in the Liver

Structural and Functional Characterization of Fibronectin in Extracellular Vesicles From Hepatocytes

Dynamic Changes in Function and Proteomic Composition of Extracellular Vesicles from Hepatic Stellate Cells during Cellular Activation

Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo

Regulation of pancreatic inflammation by connective tissue growth factor (CTGF/CCN2)

Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes

Regulation of hepatic stellate cells by connective tissue growth factor

Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes

Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis

Heparin-binding epidermal growth factor-like growth factor suppresses experimental liver fibrosis in mice

Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor

Activation of the connective tissue growth factor (CTGF)-transforming growth factor β 1 (TGF-β 1) axis in hepatitis C virus-expressing hepatocytes

Fibrogenic Signaling Is Suppressed in Hepatic Stellate Cells through Targeting of Connective Tissue Growth Factor (CCN2) by Cellular or Exosomal MicroRNA-199a-5p

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