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Key role of phosphorylation sites in ATPase domain and Linker region of MLH1 for DNA binding and functionality of MutLα

Scientific reports, 2023-08, Vol.13 (1), p.12503-12503, Article 12503

2023

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Erk Inhibition as a Promising Therapeutic Strategy for High IL-8-Secreting and Low SPTAN1-Expressing Colorectal Cancer

International journal of molecular sciences, 2024-06, Vol.25 (11), p.5658

2024

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CK2 and the Hallmarks of Cancer

Biomedicines, 2022-08, Vol.10 (8), p.1987

2022

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Investigation of the Wilson gene ATP7B transcriptional start site and the effect of core promoter alterations

Scientific reports, 2021-04, Vol.11 (1), p.7674-7674, Article 7674

2021

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Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region

PloS one, 2020-11, Vol.15 (11), p.e0242819-e0242819

2020

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Functional characterization of MLH1 missense variants unveils mechanisms of pathogenicity and clarifies role in cancer

PloS one, 2022-12, Vol.17 (12)

2022

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Downregulation of SPTAN1 is related to MLH1 deficiency and metastasis in colorectal cancer

PloS one, 2019-03, Vol.14 (3), p.e0213411-e0213411

2019

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Functional characterization of MLH1 missense variants unveils mechanisms of pathogenicity and clarifies role in cancer

PloS one, 2022-12, Vol.17 (12), p.e0278283-e0278283

2022

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High Expression of Casein Kinase 2 Alpha Is Responsible for Enhanced Phosphorylation of DNA Mismatch Repair Protein MLH1 and Increased Tumor Mutation Rates in Colorectal Cancer

Cancers, 2022-03, Vol.14 (6), p.1553

2022

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The Role of Hypoxia-Inducible Factor 1 Alpha in Acute-on-Chronic Liver Failure

International journal of molecular sciences, 2024-02, Vol.25 (3), p.1542

2024

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Promoter methylation of MLH1, PMS2, MSH2 and p16 is a phenomenon of advanced-stage HCCs

PloS one, 2014-01, Vol.9 (1), p.e84453-e84453

2014

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SPTAN1 Expression Predicts Treatment and Survival Outcomes in Colorectal Cancer

Cancers, 2021-07, Vol.13 (14), p.3638

2021

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The Role of Nonerythroid Spectrin αII in Cancer

Journal of oncology, 2019-01, Vol.2019 (2019), p.1-14

2019

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C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins

PloS one, 2012-02, Vol.7 (2), p.e31863

2012

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Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system

Gastroenterology (New York, N.Y. 1943), 2002-01, Vol.122 (1), p.211-219

2002

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Expression and secretion of the pro‑inflammatory cytokine IL‑8 is increased in colorectal cancer cells following the knockdown of non‑erythroid spectrin αII

International journal of oncology, 2020-06, Vol.56 (6), p.1551-1564

2020

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An Interstitial Deletion at 3p21.3 Results in the Genetic Fusion of MLH1 and ITGA9 in a Lynch Syndrome Family

Clinical cancer research, 2009-02, Vol.15 (3), p.762-769

2009

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Expression and secretion of the pro-inflammatory cytokine IL-8 is increased in colorectal cancer cells following the knockdown of non-erythroid spectrin [alpha]ll

International journal of oncology, 2020-06, Vol.56 (6), p.1551

2020

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Phosphorylation meets DNA mismatch repair

DNA repair, 2018-12, Vol.72, p.107-114

2018

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A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation

Nucleic acids research, 2023-07, Vol.51 (12), p.6307-6320

2023

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Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis

American journal of human genetics, 2016-08, Vol.99 (2), p.337-351

2016

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Analysis of MUTYH alternative transcript expression, promoter function, and the effect of human genetic variants

Human mutation, 2019-04, Vol.40 (4), p.472-482

2019

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Functional analysis of MMR gene VUS from potential Lynch syndrome patients

PloS one, 2024-06, Vol.19 (6), p.e0304141

2024

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Expression Defect Size among Unclassified MLH1 Variants Determines Pathogenicity in Lynch Syndrome Diagnosis

Clinical cancer research, 2013-05, Vol.19 (9), p.2432-2441

2013

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Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure

American Journal of Physiology: Cell Physiology, 2023-07, Vol.325 (1), p.C129-C140

2023

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Key role of phosphorylation sites in ATPase domain and Linker region of MLH1 for DNA binding and functionality of MutLα

Erk Inhibition as a Promising Therapeutic Strategy for High IL-8-Secreting and Low SPTAN1-Expressing Colorectal Cancer

CK2 and the Hallmarks of Cancer

Investigation of the Wilson gene ATP7B transcriptional start site and the effect of core promoter alterations

Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region

Functional characterization of MLH1 missense variants unveils mechanisms of pathogenicity and clarifies role in cancer

Downregulation of SPTAN1 is related to MLH1 deficiency and metastasis in colorectal cancer

Functional characterization of MLH1 missense variants unveils mechanisms of pathogenicity and clarifies role in cancer

High Expression of Casein Kinase 2 Alpha Is Responsible for Enhanced Phosphorylation of DNA Mismatch Repair Protein MLH1 and Increased Tumor Mutation Rates in Colorectal Cancer

The Role of Hypoxia-Inducible Factor 1 Alpha in Acute-on-Chronic Liver Failure

Promoter methylation of MLH1, PMS2, MSH2 and p16 is a phenomenon of advanced-stage HCCs

SPTAN1 Expression Predicts Treatment and Survival Outcomes in Colorectal Cancer

The Role of Nonerythroid Spectrin αII in Cancer

C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins

Functional analysis of hMLH1 variants and HNPCC-related mutations using a human expression system

Expression and secretion of the pro‑inflammatory cytokine IL‑8 is increased in colorectal cancer cells following the knockdown of non‑erythroid spectrin αII

An Interstitial Deletion at 3p21.3 Results in the Genetic Fusion of MLH1 and ITGA9 in a Lynch Syndrome Family

Expression and secretion of the pro-inflammatory cytokine IL-8 is increased in colorectal cancer cells following the knockdown of non-erythroid spectrin [alpha]ll

Phosphorylation meets DNA mismatch repair

A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation

Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis

Analysis of MUTYH alternative transcript expression, promoter function, and the effect of human genetic variants

Functional analysis of MMR gene VUS from potential Lynch syndrome patients

Expression Defect Size among Unclassified MLH1 Variants Determines Pathogenicity in Lynch Syndrome Diagnosis

Pathogenetic mechanisms and therapeutic approaches of acute-to-chronic liver failure

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