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Carbamoylphosphonates Control Tumor Cell Proliferation and Dissemination by Simultaneously Inhibiting Carbonic Anhydrase IX and Matrix Metalloproteinase-2. Toward Nontoxic Chemotherapy Targeting Tumor Microenvironment

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7875-7882

2012

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Abstract 5065: Orally active nontoxic dual MMP2 and CAIX inhibitors as anticancer therapy

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.5065-5065

Breuer, Eli

2013

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Carbamoylphosphonate Matrix Metalloproteinase Inhibitors 3: In vivo Evaluation of Cyclopentylcarbamoylphosphonic Acid in Experimental Metastasis and Angiogenesis

Clinical cancer research, 2005-05, Vol.11 (10), p.3925-3929

2005

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Phosphorus based inhibitors of matrix metalloproteinases

Comptes rendus. Chimie, 2010-08, Vol.13 (8-9), p.1191-1202

2010

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Spontaneous Lossen Rearrangement of (Phosphonoformyl)hydroxamates. The Migratory Aptitude of the Phosphonyl Group

Journal of organic chemistry, 1997-06, Vol.62 (12), p.3858-3861

1997

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Carbamoylphosphonate Matrix Metalloproteinase Inhibitors 6: cis-2-Aminocyclohexylcarbamoylphosphonic Acid, A Novel Orally Active Antimetastatic Matrix Metalloproteinase-2 Selective InhibitorSynthesis and Pharmacodynamic and Pharmacokinetic Analysis

Journal of medicinal chemistry, 2008-03, Vol.51 (5), p.1406-1414

2008

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Carbamoylphosphonates inhibit autotaxin and metastasis formation in vivo

Journal of enzyme inhibition and medicinal chemistry, 2015-09, Vol.30 (5), p.767-772

2015

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Synthesis of Enantiomeric Aminoalkylcarbamoylphosphonates and Their Evaluation as Dual-Action Anticancer MMP and Carbonic Anhydrase Inhibitors

Heteroatom chemistry, 2015-07, Vol.26 (4), p.257-269

2015

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Orally Active, Antimetastatic, Nontoxic Diphenyl Ether-Derived Carbamoylphosphonate Matrix Metalloproteinase Inhibitors

ChemMedChem, 2011-08, Vol.6 (8), p.1471-1477

2011

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Aminoalkylcarbamoylphosphonates reduce TNFα release from activated immune cells

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6518-6523

2010

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Recent non-hydroxamate matrix metalloproteinase inhibitors

Expert opinion on therapeutic patents, 2005-03, Vol.15 (3), p.253-269

2005

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Carbamoylphosphonates part 7. An efficient method for the synthesis of hindered carbamoylphosphonates using 4-nitrophenoxycarbonylphosphonate diesters

Tetrahedron letters, 2008-04, Vol.49 (18), p.2875-2877

2008

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Phosphorus based inhibitors of matrix metalloproteinases: Un panorama des recherches actuelles en chimie du phosphore : Un hommage à la mémoire de Pascal Le Floch

Comptes rendus. Chimie, 2010, Vol.13 (8-9), p.1191-1202

2010

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Nitroxides

Nitrones, Nitronates and Nitroxides (1989), 1989, p.313-370

1989

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Tumor Microenvironment as Target in Cancer Therapy

Annual Reports in Medicinal Chemistry, 2014, Vol.49, p.269-284

2014

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Glossary of terms related to pharmaceutics (IUPAC Recommendations 2009)

Pure and applied chemistry, 2009-05, Vol.81 (5), p.971-999

2009

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Ring–chain tautomerism and protolytic equilibria of 3-hydroxy-3-phosphonoisobenzofuranone studied by 1H, 13C and 31P NMR-controlled titrations

New journal of chemistry, 2008, Vol.32 (9), p.1608

2008

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A Peptide Prodrug Approach for Improving Bisphosphonate Oral Absorption

Journal of medicinal chemistry, 2000-10, Vol.43 (20), p.3641-3652

2000

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Methyltrifluoropyruvate imines possessing N-oxalyl and N-phosphonoformyl groups--precursors to a variety of alpha-CF3-alpha-amino acid derivatives

Organic & biomolecular chemistry, 2006-10, Vol.4 (19), p.3669-3674

2006

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Carbamoylphosphonate-based matrix metalloproteinase inhibitor metal complexes: solution studies and stability constants. Towards a zinc-selective binding group

Journal of biological inorganic chemistry, 2004-04, Vol.9 (3), p.307-315

2004

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Carbamoylphosphonates, a New Class of in Vivo Active Matrix Metalloproteinase Inhibitors. 1. Alkyl- and Cycloalkylcarbamoylphosphonic Acids

Journal of medicinal chemistry, 2004-05, Vol.47 (11), p.2826-2832

2004

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Carbamoylphosphonate MMP inhibitors. Part 4: The influence of chirality and geometrical isomerism on the potency and selectivity of inhibition

Tetrahedron: asymmetry, 2004-08, Vol.15 (15), p.2415-2420

2004

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Carbamoylphosphonate Matrix Metalloproteinase Inhibitors 6: cis-2-Aminocyclohexylcarbamoylphosphonic Acid, A Novel Orally Active Antimetastatic Matrix Metalloproteinase-2 Selective InhibitorSynthesis and Pharmacodynamic and Pharmacokinetic Analysis

Journal of medicinal chemistry, 2008-07, Vol.51 (14), p.4357-4358

2008

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Aldol-Type Cyclization of Bisacylphosphonates. A Unique Concerted Catalytic Effect of Diamines

Phosphorus, sulfur, and silicon and the related elements, 1996-04, Vol.111 (1-4), p.164-164

1996

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An autoxidation study of C2 substituted pyrimidine amino reductones

Tetrahedron, 2006-06, Vol.62 (23), p.5469-5473

2006

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Carbamoylphosphonates Control Tumor Cell Proliferation and Dissemination by Simultaneously Inhibiting Carbonic Anhydrase IX and Matrix Metalloproteinase-2. Toward Nontoxic Chemotherapy Targeting Tumor Microenvironment

Abstract 5065: Orally active nontoxic dual MMP2 and CAIX inhibitors as anticancer therapy

Carbamoylphosphonate Matrix Metalloproteinase Inhibitors 3: In vivo Evaluation of Cyclopentylcarbamoylphosphonic Acid in Experimental Metastasis and Angiogenesis

Phosphorus based inhibitors of matrix metalloproteinases

Spontaneous Lossen Rearrangement of (Phosphonoformyl)hydroxamates. The Migratory Aptitude of the Phosphonyl Group

Carbamoylphosphonate Matrix Metalloproteinase Inhibitors 6: cis-2-Aminocyclohexylcarbamoylphosphonic Acid, A Novel Orally Active Antimetastatic Matrix Metalloproteinase-2 Selective InhibitorSynthesis and Pharmacodynamic and Pharmacokinetic Analysis

Carbamoylphosphonates inhibit autotaxin and metastasis formation in vivo

Synthesis of Enantiomeric Aminoalkylcarbamoylphosphonates and Their Evaluation as Dual-Action Anticancer MMP and Carbonic Anhydrase Inhibitors

Orally Active, Antimetastatic, Nontoxic Diphenyl Ether-Derived Carbamoylphosphonate Matrix Metalloproteinase Inhibitors

Aminoalkylcarbamoylphosphonates reduce TNFα release from activated immune cells

Recent non-hydroxamate matrix metalloproteinase inhibitors

Carbamoylphosphonates part 7. An efficient method for the synthesis of hindered carbamoylphosphonates using 4-nitrophenoxycarbonylphosphonate diesters

Phosphorus based inhibitors of matrix metalloproteinases: Un panorama des recherches actuelles en chimie du phosphore : Un hommage à la mémoire de Pascal Le Floch

Nitroxides

Tumor Microenvironment as Target in Cancer Therapy

Glossary of terms related to pharmaceutics (IUPAC Recommendations 2009)

Ring–chain tautomerism and protolytic equilibria of 3-hydroxy-3-phosphonoisobenzofuranone studied by 1H, 13C and 31P NMR-controlled titrations

A Peptide Prodrug Approach for Improving Bisphosphonate Oral Absorption

Methyltrifluoropyruvate imines possessing N-oxalyl and N-phosphonoformyl groups--precursors to a variety of alpha-CF3-alpha-amino acid derivatives

Carbamoylphosphonate-based matrix metalloproteinase inhibitor metal complexes: solution studies and stability constants. Towards a zinc-selective binding group

Carbamoylphosphonates, a New Class of in Vivo Active Matrix Metalloproteinase Inhibitors. 1. Alkyl- and Cycloalkylcarbamoylphosphonic Acids

Carbamoylphosphonate MMP inhibitors. Part 4: The influence of chirality and geometrical isomerism on the potency and selectivity of inhibition

Carbamoylphosphonate Matrix Metalloproteinase Inhibitors 6: cis-2-Aminocyclohexylcarbamoylphosphonic Acid, A Novel Orally Active Antimetastatic Matrix Metalloproteinase-2 Selective InhibitorSynthesis and Pharmacodynamic and Pharmacokinetic Analysis

Aldol-Type Cyclization of Bisacylphosphonates. A Unique Concerted Catalytic Effect of Diamines

An autoxidation study of C2 substituted pyrimidine amino reductones

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