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Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (6), p.2069-2074

2005

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Orphan receptor HNF-4 and bZip protein C/EBP alpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription

The Journal of biological chemistry, 1993-08, Vol.268 (22), p.16831-16838

1993

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Hepatic Scavenger Receptor BI Promotes Rapid Clearance of High Density Lipoprotein Free Cholesterol and Its Transport into Bile

The Journal of biological chemistry, 1999-11, Vol.274 (47), p.33398-33402

1999

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Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse

Proceedings of the National Academy of Sciences - PNAS, 1994-09, Vol.91 (20), p.9607-9611

1994

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Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction

The New England journal of medicine, 1993-12, Vol.329 (25), p.1829-1834

1993

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Scavenger receptor BI (SR-BI) is up-regulated in adrenal gland in apolipoprotein A-I and hepatic lipase knock-out mice as a response to depletion of cholesterol stores. In vivo evidence that SR-BI is a functional high density lipoprotein receptor under feedback control

The Journal of biological chemistry, 1996-08, Vol.271 (35), p.21001-21004

1996

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Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice

Proceedings of the National Academy of Sciences - PNAS, 1996-09, Vol.93 (19), p.10022-10027

1996

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Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility

Proceedings of the National Academy of Sciences - PNAS, 1996-12, Vol.93 (25), p.14788-14794

1996

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Ultrastructure of early lipid accumulation in ApoE-deficient mice

Arteriosclerosis, thrombosis, and vascular biology, 1999-04, Vol.19 (4), p.847-853

1999

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Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase

Proceedings of the National Academy of Sciences - PNAS, 1997-09, Vol.94 (19), p.10261-10266

1997

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Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption

Proceedings of the National Academy of Sciences - PNAS, 1998-08, Vol.95 (17), p.10194-10199

1998

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Intestinal Absorption of Dietary Cholesteryl Ester Is Decreased but Retinyl Ester Absorption Is Normal in Carboxyl Ester Lipase Knockout Mice

Biochemistry (Easton), 1999-03, Vol.38 (13), p.4143-4149

1999

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Cholesterol feeding of mice expressing cholesterol 7α-hydroxylase increases bile acid pool size despite decreased enzyme activity

Proceedings of the National Academy of Sciences - PNAS, 2004-02, Vol.101 (7), p.1846-1851

2004

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Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels

Proceedings of the National Academy of Sciences - PNAS, 1999-03, Vol.96 (6), p.3165-3170

1999

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Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels

Journal of lipid research, 1994-11, Vol.35 (11), p.1918-1924

1994

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Transgenic Mouse Models of Lipoprotein Metabolism and Atherosclerosis

Proceedings of the National Academy of Sciences - PNAS, 1993-09, Vol.90 (18), p.8314-8318

Breslow, Jan L.

1993

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Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice

The Journal of biological chemistry, 1991-06, Vol.266 (17), p.10796-10801

1991

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A Novel Missense Mutation in the Gene for Lipoprotein Lipase Resulting in a Highly Conservative Amino Acid Substitution (Asp180→Glu) Causes Familial Chylomicronemia (Type I Hyperlipoproteinemia)

Genomics (San Diego, Calif.), 1993-11, Vol.18 (2), p.392-396

1993

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Apolipoprotein E gene expression in mouse 3T3-L1 adipocytes and human adipose tissue and its regulation by differentiation and lipid content

The Journal of biological chemistry, 1991-06, Vol.266 (16), p.10583-10588

1991

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Lipoprotein(a) reduction by N-acetylcysteine

The Lancet (British edition), 1991-01, Vol.337 (8735), p.203-204

1991

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Human cholesteryl ester transfer protein gene proximal promoter contains dietary cholesterol positive responsive elements and mediates expression in small intestine and periphery while predominant liver and spleen expression is controlled by 5'-distal sequences. Cis-acting sequences mapped in transgenic mice

The Journal of biological chemistry, 1996-12, Vol.271 (50), p.31831-31838

1996

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Dietary Fat Elevates Hepatic ApoA-I Production by Increasing the Fraction of Apolipoprotein A-I mRNA in the Translating Pool (∗)

The Journal of biological chemistry, 1995-08, Vol.270 (34), p.19833-19838

1995

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Dietary monounsaturated fatty acids and carbohydrates increase VLDL-cholesterol and atherosclerosis in mice via an apo E dependent pathway

Atherosclerosis, 2000-07, Vol.151 (1), p.113-113

2000

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Plasma lipoprotein(a) concentration is controlled by apolipoprotein(a) (apo(a)) protein size and the abundance of hepatic apo(a) mRNA in a cynomolgus monkey model

The Journal of biological chemistry, 1991-07, Vol.266 (21), p.13866-13872

1991

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ApoE Distribution Among Lipoproteins of Rhesus Monkeys Is Modulated by Dietary Fat and Cholesterol

The Journal of nutrition, 1986-09, Vol.116 (9), p.1611-1619

1986

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Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment

Orphan receptor HNF-4 and bZip protein C/EBP alpha bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription

Hepatic Scavenger Receptor BI Promotes Rapid Clearance of High Density Lipoprotein Free Cholesterol and Its Transport into Bile

Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse

Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction

Scavenger receptor BI (SR-BI) is up-regulated in adrenal gland in apolipoprotein A-I and hepatic lipase knock-out mice as a response to depletion of cholesterol stores. In vivo evidence that SR-BI is a functional high density lipoprotein receptor under feedback control

Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice

Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility

Ultrastructure of early lipid accumulation in ApoE-deficient mice

Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase

Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption

Intestinal Absorption of Dietary Cholesteryl Ester Is Decreased but Retinyl Ester Absorption Is Normal in Carboxyl Ester Lipase Knockout Mice

Cholesterol feeding of mice expressing cholesterol 7α-hydroxylase increases bile acid pool size despite decreased enzyme activity

Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels

Transcriptional regulation of the apoC-III gene by insulin in diabetic mice: correlation with changes in plasma triglyceride levels

Transgenic Mouse Models of Lipoprotein Metabolism and Atherosclerosis

Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice

A Novel Missense Mutation in the Gene for Lipoprotein Lipase Resulting in a Highly Conservative Amino Acid Substitution (Asp180→Glu) Causes Familial Chylomicronemia (Type I Hyperlipoproteinemia)

Apolipoprotein E gene expression in mouse 3T3-L1 adipocytes and human adipose tissue and its regulation by differentiation and lipid content

Lipoprotein(a) reduction by N-acetylcysteine

Dietary Fat Elevates Hepatic ApoA-I Production by Increasing the Fraction of Apolipoprotein A-I mRNA in the Translating Pool (∗)

Dietary monounsaturated fatty acids and carbohydrates increase VLDL-cholesterol and atherosclerosis in mice via an apo E dependent pathway

Plasma lipoprotein(a) concentration is controlled by apolipoprotein(a) (apo(a)) protein size and the abundance of hepatic apo(a) mRNA in a cynomolgus monkey model

ApoE Distribution Among Lipoproteins of Rhesus Monkeys Is Modulated by Dietary Fat and Cholesterol

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