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Treg Cell Function in Rheumatoid Arthritis Is Compromised by CTLA‐4 Promoter Methylation Resulting in a Failure to Activate the Indoleamine 2,3‐Dioxygenase Pathway

Arthritis & rheumatology (Hoboken, N.J.), 2014-09, Vol.66 (9), p.2344-2354

2014

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Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course

Scientific reports, 2020-06, Vol.10 (1), p.8830, Article 8830

2020

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A novel upstream enhancer of FOXP3, sensitive to methylation‐induced silencing, exhibits dysregulated methylation in rheumatoid arthritis Treg cells

European journal of immunology, 2014-10, Vol.44 (10), p.2968-2978

2014

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Evidence that cytokines play a role in rheumatoid arthritis

The Journal of clinical investigation, 2008-11, Vol.118 (11), p.3537-3545

2008

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Recent developments in the immunobiology of rheumatoid arthritis

Arthritis research & therapy, 2008-01, Vol.10 (2), p.204-204

2008

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Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells

Proceedings of the National Academy of Sciences - PNAS, 2011-10, Vol.108 (40), p.16717-16722

2011

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Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures

The Journal of immunology (1950), 2008-12, Vol.181 (11), p.8002-8009

2008

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ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

Annual review of immunology, 1996-01, Vol.14 (1), p.397-440

1996

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Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood

The Journal of immunology (1950), 2010-09, Vol.185 (6), p.3694-3701

2010

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Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells

BMC biotechnology, 2013-11, Vol.13 (1), p.98-98, Article 98

2013

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Interleukin-10 regulates TNF-α-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism

European journal of immunology, 2008-04, Vol.38 (4), p.1106-1117

2008

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Lung-marginated Monocytes Modulate Pulmonary Microvascular Injury during Early Endotoxemia

American journal of respiratory and critical care medicine, 2005-11, Vol.172 (9), p.1119-1127

2005

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Anti-TNF therapy: Where have we got to in 2005?

Journal of autoimmunity, 2005, Vol.25, p.26-28

2005

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CXCR4 and vascular cell adhesion molecule 1 are key chemokine/adhesion receptors in the migration of cytokine-activated T cells

Arthritis & rheumatology (Hoboken, N.J.), 2012-07, Vol.64 (7), p.2137-2146

2012

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Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

Arthritis research & therapy, 2010-01, Vol.12 (3), p.R107-R107, Article R107

2010

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The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: Major contributors or essential homeostatic modulators?

Immunology letters, 2011-05, Vol.136 (2), p.115-121

2011

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The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis

Best practice & research. Clinical rheumatology, 2004-02, Vol.18 (1), p.59-80

2004

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Selective Blockade of Tumor Necrosis Factor Receptor I Inhibits Proinflammatory Cytokine and Chemokine Production in Human Rheumatoid Arthritis Synovial Membrane Cell Cultures

Arthritis & rheumatology (Hoboken, N.J.), 2013-09, Vol.65 (9), p.2262-2273

2013

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Bruton's Tyrosine Kinase Is Required for TLR2 and TLR4-Induced TNF, but Not IL-6, Production

Journal of Immunology, 2006-03, Vol.176 (6), p.3635-3641

2006

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Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism

The Journal of immunology (1950), 2012-02, Vol.188 (3), p.1307-1317

2012

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Blockade of NKG2D ameliorates disease in mice with collagen‐induced arthritis: A potential pathogenic role in chronic inflammatory arthritis

Arthritis & rheumatology (Hoboken, N.J.), 2011-09, Vol.63 (9), p.2617-2629

2011

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Activation of p38 mitogen-activated protein kinase is critical step for acquisition of effector function in cytokine-activated T cells, but acts as a negative regulator in T cells activated through the T-cell receptor

Immunology, 2011, Vol.132 (1), p.104-110

2011

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TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines

Rheumatology (Oxford, England), 2009-11, Vol.48 (11), p.1352-1358

2009

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Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production

The Journal of experimental medicine, 2003-06, Vol.197 (12), p.1603-1611

2003

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Effective antigen presentation by dendritic cells is NF-κB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines

International immunology, 2001-05, Vol.13 (5), p.675-683

2001

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Treg Cell Function in Rheumatoid Arthritis Is Compromised by CTLA‐4 Promoter Methylation Resulting in a Failure to Activate the Indoleamine 2,3‐Dioxygenase Pathway

Novel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course

A novel upstream enhancer of FOXP3, sensitive to methylation‐induced silencing, exhibits dysregulated methylation in rheumatoid arthritis Treg cells

Evidence that cytokines play a role in rheumatoid arthritis

Recent developments in the immunobiology of rheumatoid arthritis

Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells

Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood

Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells

Interleukin-10 regulates TNF-α-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism

Lung-marginated Monocytes Modulate Pulmonary Microvascular Injury during Early Endotoxemia

Anti-TNF therapy: Where have we got to in 2005?

CXCR4 and vascular cell adhesion molecule 1 are key chemokine/adhesion receptors in the migration of cytokine-activated T cells

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: Major contributors or essential homeostatic modulators?

The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis

Selective Blockade of Tumor Necrosis Factor Receptor I Inhibits Proinflammatory Cytokine and Chemokine Production in Human Rheumatoid Arthritis Synovial Membrane Cell Cultures

Bruton's Tyrosine Kinase Is Required for TLR2 and TLR4-Induced TNF, but Not IL-6, Production

Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism

Blockade of NKG2D ameliorates disease in mice with collagen‐induced arthritis: A potential pathogenic role in chronic inflammatory arthritis

Activation of p38 mitogen-activated protein kinase is critical step for acquisition of effector function in cytokine-activated T cells, but acts as a negative regulator in T cells activated through the T-cell receptor

TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines

Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production

Effective antigen presentation by dendritic cells is NF-κB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines

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