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Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys

mAbs, 2015-09, Vol.7 (5), p.829-837

2015

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Safety Assessment and Dose Selection for First-in-Human Clinical Trials With Immunomodulatory Monoclonal Antibodies

Clinical pharmacology and therapeutics, 2009-03, Vol.85 (3), p.247-258

2009

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HESI/FDA workshop on immunomodulators and cancer risk assessment: Building blocks for a weight-of-evidence approach

Regulatory toxicology and pharmacology, 2016-03, Vol.75, p.72-80

2016

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Non-clinical safety evaluation of novel vaccines and adjuvants: new products, new strategies

Vaccine, 2005-05, Vol.23 (24), p.3210-3222

2005

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CD44 Expression by Leucocytes in Rheumatoid Arthritis and Modulation by Specific Antibody: Implications for Lymphocyte Adhesion to Endothelial Cells and Synoviocytes In Vitro

Scandinavian journal of immunology, 1997-02, Vol.45 (2), p.213-220

1997

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Characterization of Salmonella enterica Derivatives Harboring Defined aroC and Salmonella Pathogenicity Island 2 Type III Secretion System (ssaV) Mutations by Immunization of Healthy Volunteers

Infection and Immunity, 2002-07, Vol.70 (7), p.3457-3467

2002

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Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis

Nature medicine, 1995, Vol.1 (6), p.558-563

1995

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Antibodies against a truncated Staphylococcus aureus fibronectin-binding protein protect against dissemination of infection in the rat

Vaccine, 2001-05, Vol.19 (25), p.3376-3383

2001

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Preclinical safety testing of biotechnology-derived pharmaceuticals: Understanding the issues and addressing the challenges

Molecular biotechnology, 2004-05, Vol.27 (1), p.59-74

2004

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Human monocyte/macrophage response to cobalt-chromium corrosion products and titanium particles in patients with total joint replacements

Journal of orthopaedic research, 1997-01, Vol.15 (1), p.40-49

1997

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Inactivated recombinant plant virus protects dogs from a lethal challenge with canine parvovirus

Vaccine, 2001-06, Vol.19 (27), p.3661-3670

2001

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Salmonella typhi and S. typhimurium derivatives harbouring deletions in aromatic biosynthesis and Salmonella Pathogenicity Island-2 (SPI-2) genes as vaccines and vectors

Vaccine, 2003-01, Vol.21 (5), p.538-548

2003

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Optimization of Salmonella enterica Serovar Typhi ΔaroC ΔssaV Derivatives as Vehicles for Delivering Heterologous Antigens by Chromosomal Integration and In Vivo Inducible Promoters

Infection and Immunity, 2005-01, Vol.73 (1), p.362-368

2005

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Chimeric Plant Virus Particles Administered Nasally or Orally Induce Systemic and Mucosal Immune Responses in Mice

Journal of Virology, 1999-02, Vol.73 (2), p.930-938

1999

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CD44 is involved in selective leucocyte extravasation during inflammatory central nervous system disease

Immunology, 1999-11, Vol.98 (3), p.427-435

1999

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Characterization of the immune response to canine parvovirus induced by vaccination with chimaeric plant viruses

Vaccine, 2002-06, Vol.20 (21), p.2727-2734

2002

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Immunogenicity of peptides derived from a fibronectin-binding protein of S. aureus expressed on two different plant viruses

Vaccine, 1999-04, Vol.17 (15), p.1846-1857

1999

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Intranasal immunization with a plant virus expressing a peptide from HIV-1 gp41 stimulates better mucosal and systemic HIV-1-specific IgA and IgG than oral immunization

Journal of immunological methods, 1998-11, Vol.220 (1), p.93-103

1998

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Analysis of the ability of five adjuvants to enhance immune responses to a chimeric plant virus displaying an HIV-1 peptide

Vaccine, 1999-03, Vol.17 (11), p.1359-1368

1999

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Pseudomonas aeruginosa outer-membrane protein F epitopes are highly immunogenic in mice when expressed on a plant virus

Microbiology (Society for General Microbiology), 1999-01, Vol.145 ( Pt 1) (1), p.211-220

1999

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A chimaeric plant virus vaccine protects mice against a bacterial infection

Microbiology (Society for General Microbiology), 1999-08, Vol.145 ( Pt 8) (8), p.2061-2067

1999

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Effect of priming/booster immunisation protocols on immune response to canine parvovirus peptide induced by vaccination with a chimaeric plant virus construct

Vaccine, 2003-06, Vol.21 (19), p.2441-2447

2003

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Cowpea mosaic virus as a vaccine carrier of heterologous antigens

Molecular biotechnology, 2001, Vol.17 (1), p.15-26

2001

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A role for alpha 4-integrin in the pathology following Semliki Forest virus infection

Journal of neuroimmunology, 2000-07, Vol.106 (1-2), p.60-68

2000

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Anti‐CD44 treatment does not prevent the extravasation of autopathogenic T cells to the thyroid in experimental autoimmune thyroiditis

Immunology, 1999-07, Vol.97 (3), p.533-539

1999

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Integrated pharmacokinetic, pharmacodynamic and immunogenicity profiling of an anti-CCL21 monoclonal antibody in cynomolgus monkeys

Safety Assessment and Dose Selection for First-in-Human Clinical Trials With Immunomodulatory Monoclonal Antibodies

HESI/FDA workshop on immunomodulators and cancer risk assessment: Building blocks for a weight-of-evidence approach

Non-clinical safety evaluation of novel vaccines and adjuvants: new products, new strategies

CD44 Expression by Leucocytes in Rheumatoid Arthritis and Modulation by Specific Antibody: Implications for Lymphocyte Adhesion to Endothelial Cells and Synoviocytes In Vitro

Characterization of Salmonella enterica Derivatives Harboring Defined aroC and Salmonella Pathogenicity Island 2 Type III Secretion System (ssaV) Mutations by Immunization of Healthy Volunteers

Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis

Antibodies against a truncated Staphylococcus aureus fibronectin-binding protein protect against dissemination of infection in the rat

Preclinical safety testing of biotechnology-derived pharmaceuticals: Understanding the issues and addressing the challenges

Human monocyte/macrophage response to cobalt-chromium corrosion products and titanium particles in patients with total joint replacements

Inactivated recombinant plant virus protects dogs from a lethal challenge with canine parvovirus

Salmonella typhi and S. typhimurium derivatives harbouring deletions in aromatic biosynthesis and Salmonella Pathogenicity Island-2 (SPI-2) genes as vaccines and vectors

Optimization of Salmonella enterica Serovar Typhi ΔaroC ΔssaV Derivatives as Vehicles for Delivering Heterologous Antigens by Chromosomal Integration and In Vivo Inducible Promoters

Chimeric Plant Virus Particles Administered Nasally or Orally Induce Systemic and Mucosal Immune Responses in Mice

CD44 is involved in selective leucocyte extravasation during inflammatory central nervous system disease

Characterization of the immune response to canine parvovirus induced by vaccination with chimaeric plant viruses

Immunogenicity of peptides derived from a fibronectin-binding protein of S. aureus expressed on two different plant viruses

Intranasal immunization with a plant virus expressing a peptide from HIV-1 gp41 stimulates better mucosal and systemic HIV-1-specific IgA and IgG than oral immunization

Analysis of the ability of five adjuvants to enhance immune responses to a chimeric plant virus displaying an HIV-1 peptide

Pseudomonas aeruginosa outer-membrane protein F epitopes are highly immunogenic in mice when expressed on a plant virus

A chimaeric plant virus vaccine protects mice against a bacterial infection

Effect of priming/booster immunisation protocols on immune response to canine parvovirus peptide induced by vaccination with a chimaeric plant virus construct

Cowpea mosaic virus as a vaccine carrier of heterologous antigens

A role for alpha 4-integrin in the pathology following Semliki Forest virus infection

Anti‐CD44 treatment does not prevent the extravasation of autopathogenic T cells to the thyroid in experimental autoimmune thyroiditis

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