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Conjugate Vaccine Immunotherapy for Substance Use Disorder

Pharmacological reviews, 2017-07, Vol.69 (3), p.298-315

2017

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Combatting Synthetic Designer Opioids: A Conjugate Vaccine Ablates Lethal Doses of Fentanyl Class Drugs

Angewandte Chemie (International ed.), 2016-03, Vol.55 (11), p.3772-3775

International ed. in English, 2016

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Investigation of monoclonal antibody CSX-1004 for fentanyl overdose

Nature communications, 2023-12, Vol.14 (1), p.7700-7700, Article 7700

2023

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Conjugate Vaccine Immunotherapy for Substance Use Disorder

Pharmacological reviews, 2017-07, Vol.69 (3), p.298-315

2017

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Monoclonal Antibodies for Combating Synthetic Opioid Intoxication

Journal of the American Chemical Society, 2019-07, Vol.141 (26), p.10489-10503

2019

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Development of a Clinically Viable Heroin Vaccine

Journal of the American Chemical Society, 2017-06, Vol.139 (25), p.8601-8611

2017

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Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality

Molecular pharmaceutics, 2018-03, Vol.15 (3), p.1062-1072

2018

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Iridium Complexes of CCC-Pincer N-Heterocyclic Carbene Ligands: Synthesis and Catalytic C−H Functionalization

Organometallics, 2010-07, Vol.29 (13), p.3019-3026

2010

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Enhancement of a Heroin Vaccine through Hapten Deuteration

Journal of the American Chemical Society, 2020-08, Vol.142 (31), p.13294-13298

2020

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Injection Route and TLR9 Agonist Addition Significantly Impact Heroin Vaccine Efficacy

Molecular pharmaceutics, 2014-03, Vol.11 (3), p.1075-1080

2014

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Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats

Neuropsychopharmacology (New York, N.Y.), 2019-09, Vol.44 (10), p.1681-1689

2019

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A Highly Efficacious Carfentanil Vaccine That Blunts Opioid-Induced Antinociception and Respiratory Depression

ACS chemical biology, 2021-02, Vol.16 (2), p.277-282

2021

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Vaccine blunts fentanyl potency in male rhesus monkeys

Neuropharmacology, 2019-11, Vol.158, p.107730-107730, Article 107730

2019

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Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays

Journal of medicinal chemistry, 2017-01, Vol.60 (1), p.338-348

2017

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A synthetic opioid vaccine attenuates fentanyl-vs-food choice in male and female rhesus monkeys

Drug and alcohol dependence, 2021-01, Vol.218, p.108348-108348, Article 108348

2021

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Dynamic vaccine blocks relapse to compulsive intake of heroin

Proceedings of the National Academy of Sciences - PNAS, 2013-05, Vol.110 (22), p.9036-9041

2013

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Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone

Drug and alcohol dependence, 2019-11, Vol.204, p.107501-107501, Article 107501

2019

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Methamphetamine Vaccines: Improvement through Hapten Design

Journal of medicinal chemistry, 2016-04, Vol.59 (8), p.3878-3885

2016

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Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain

Chemical communications (Cambridge, England), 2016-10, Vol.52 (84), p.12521-12524

2016

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Investigating the Effects of a Hydrolytically Stable Hapten and a Th1 Adjuvant on Heroin Vaccine Performance

Journal of medicinal chemistry, 2012-12, Vol.55 (23), p.10776-10780

2012

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Developing Translational Vaccines against Heroin and Fentanyl through Investigation of Adjuvants and Stability

Molecular pharmaceutics, 2021-01, Vol.18 (1), p.228-235

2021

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Sulfonate-isosteric replacement examined within heroin-hapten vaccine design

Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (17), p.127388-127388, Article 127388

2020

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Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats

Neuropharmacology, 2017-04, Vol.116, p.1-8

2017

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Rigid, Sterically Diverse N-Heterocyclic Carbene-Pyridine Chelates: Synthesis, Mild Palladation, and Palladium-Catalyzed Allylic Substitution

Organometallics, 2009-09, Vol.28 (17), p.5244-5252

2009

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Benzoquinones as inhibitors of botulinum neurotoxin serotype A

Bioorganic & medicinal chemistry, 2014-08, Vol.22 (15), p.3971-3981

2014

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Conjugate Vaccine Immunotherapy for Substance Use Disorder

Combatting Synthetic Designer Opioids: A Conjugate Vaccine Ablates Lethal Doses of Fentanyl Class Drugs

Investigation of monoclonal antibody CSX-1004 for fentanyl overdose

Conjugate Vaccine Immunotherapy for Substance Use Disorder

Monoclonal Antibodies for Combating Synthetic Opioid Intoxication

Development of a Clinically Viable Heroin Vaccine

Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality

Iridium Complexes of CCC-Pincer N-Heterocyclic Carbene Ligands: Synthesis and Catalytic C−H Functionalization

Enhancement of a Heroin Vaccine through Hapten Deuteration

Injection Route and TLR9 Agonist Addition Significantly Impact Heroin Vaccine Efficacy

Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats

A Highly Efficacious Carfentanil Vaccine That Blunts Opioid-Induced Antinociception and Respiratory Depression

Vaccine blunts fentanyl potency in male rhesus monkeys

Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays

A synthetic opioid vaccine attenuates fentanyl-vs-food choice in male and female rhesus monkeys

Dynamic vaccine blocks relapse to compulsive intake of heroin

Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone

Methamphetamine Vaccines: Improvement through Hapten Design

Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain

Investigating the Effects of a Hydrolytically Stable Hapten and a Th1 Adjuvant on Heroin Vaccine Performance

Developing Translational Vaccines against Heroin and Fentanyl through Investigation of Adjuvants and Stability

Sulfonate-isosteric replacement examined within heroin-hapten vaccine design

Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats

Rigid, Sterically Diverse N-Heterocyclic Carbene-Pyridine Chelates: Synthesis, Mild Palladation, and Palladium-Catalyzed Allylic Substitution

Benzoquinones as inhibitors of botulinum neurotoxin serotype A

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