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Effectiveness of COVID-19 mRNA Vaccination in Preventing COVID-19-Associated Hospitalization Among Adults with Previous SARS-CoV-2 Infection - United States, June 2021-February 2022

MMWR. Morbidity and mortality weekly report, 2022-04, Vol.71 (15), p.549-555

2022

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Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

Nature structural & molecular biology, 2017-02, Vol.24 (2), p.108

2017

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Ruthenium Half-Sandwich Complexes Bound to Protein Kinase Pim-1

Angewandte Chemie (International ed.), 2006-02, Vol.45 (10), p.1580-1585

2006

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Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4320-4342

2013

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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7818-7839

2016

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An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells

Cancer research (Chicago, Ill.), 2007, Vol.67 (1), p.209-217

2007

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A Modular Synthesis of the Lamellarins: Total Synthesis of Lamellarin G Trimethyl Ether

Journal of organic chemistry, 2004-04, Vol.69 (7), p.2362-2366

2004

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Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor

PloS one, 2009-10, Vol.4 (10), p.e7112-e7112

2009

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Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain

PloS one, 2015-09, Vol.10 (9), p.e0138140-e0138140

2015

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Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand

Organic & biomolecular chemistry, 2007-01, Vol.5 (8), p.1218-1227

2007

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement

ACS medicinal chemistry letters, 2016-12, Vol.7 (12), p.1062-1067

2016

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Ruthenium Half-Sandwich Complexes as Protein Kinase Inhibitors: An N-Succinimidyl Ester for Rapid Derivatizations of the Cyclopentadienyl Moiety

Organic letters, 2006-11, Vol.8 (24), p.5465-5468

2006

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Rapid Access to Unexplored Chemical Space by Ligand Scanning around a Ruthenium Center: Discovery of Potent and Selective Protein Kinase Inhibitors

Journal of the American Chemical Society, 2006-01, Vol.128 (3), p.877-884

2006

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Discovery of a Class of Novel Tankyrase Inhibitors that Bind to Both the Nicotinamide Pocket and the Induced Pocket

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.1341-1345

2013

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The Crystal Structure of BRAF in Complex with an Organoruthenium Inhibitor Reveals a Mechanism for Inhibition of an Active Form of BRAF Kinase

Biochemistry (Easton), 2009-06, Vol.48 (23), p.5187-5198

2009

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The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors

Journal of medicinal chemistry, 2017-02, Vol.60 (3), p.1105-1125

2017

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Exploring Chemical Space with Organometallics: Ruthenium Complexes as Protein Kinase Inhibitors

Synlett, 2007-05, Vol.2007 (8), p.1177-1189

2007

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An Organometallic Inhibitor for Glycogen Synthase Kinase 3

Journal of the American Chemical Society, 2004-10, Vol.126 (42), p.13594-13595

2004

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Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10003-10015

2013

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Organometallic Compounds with Biological Activity: A Very Selective and Highly Potent Cellular Inhibitor for Glycogen Synthase Kinase 3

Chembiochem : a European journal of chemical biology, 2006-09, Vol.7 (9), p.1443-1450

2006

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Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators

European journal of medicinal chemistry, 2017-09, Vol.137, p.63-75

2017

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The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (15), p.3477-3485

2017

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Identification of a Potent, State-Dependent Inhibitor of Nav1.7 with Oral Efficacy in the Formalin Model of Persistent Pain

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4427-4445

2011

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Effectiveness of COVID-19 mRNA Vaccination in Preventing COVID-19-Associated Hospitalization Among Adults with Previous SARS-CoV-2 Infection - United States, June 2021-February 2022

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

Ruthenium Half-Sandwich Complexes Bound to Protein Kinase Pim-1

Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors

An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells

A Modular Synthesis of the Lamellarins: Total Synthesis of Lamellarin G Trimethyl Ether

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor

Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain

Ruthenium half-sandwich complexes as protein kinase inhibitors: derivatization of the pyridocarbazole pharmacophore ligand

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement

Ruthenium Half-Sandwich Complexes as Protein Kinase Inhibitors: An N-Succinimidyl Ester for Rapid Derivatizations of the Cyclopentadienyl Moiety

Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis

Rapid Access to Unexplored Chemical Space by Ligand Scanning around a Ruthenium Center: Discovery of Potent and Selective Protein Kinase Inhibitors

Discovery of a Class of Novel Tankyrase Inhibitors that Bind to Both the Nicotinamide Pocket and the Induced Pocket

The Crystal Structure of BRAF in Complex with an Organoruthenium Inhibitor Reveals a Mechanism for Inhibition of an Active Form of BRAF Kinase

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities

The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors

Exploring Chemical Space with Organometallics: Ruthenium Complexes as Protein Kinase Inhibitors

An Organometallic Inhibitor for Glycogen Synthase Kinase 3

Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors

Organometallic Compounds with Biological Activity: A Very Selective and Highly Potent Cellular Inhibitor for Glycogen Synthase Kinase 3

Applications of parallel synthetic lead hopping and pharmacophore-based virtual screening in the discovery of efficient glycine receptor potentiators

The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement

Identification of a Potent, State-Dependent Inhibitor of Nav1.7 with Oral Efficacy in the Formalin Model of Persistent Pain

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