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Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting

Biochemical Society transactions, 2018-12, Vol.46 (6), p.1753-1770

2018

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Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly

Nature communications, 2022-02, Vol.13 (1), p.1040-15, Article 1040

2022

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Structural Insights into FGFR Kinase Isoform Selectivity: Diverse Binding Modes of AZD4547 and Ponatinib in Complex with FGFR1 and FGFR4

Structure (London), 2014-12, Vol.22 (12), p.1764-1774

2014

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RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

Nature communications, 2021-06, Vol.12 (1), p.4045-4045, Article 4045

2021

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Dimers of D76N-β2-microglobulin display potent antiamyloid aggregation activity

The Journal of biological chemistry, 2022-12, Vol.298 (12), p.102659-102659, Article 102659

2022

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Fragment screening to predict druggability (ligandability) and lead discovery success

Drug discovery today, 2011-04, Vol.16 (7), p.284-287

2011

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Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence

The Journal of biological chemistry, 2016-01, Vol.291 (4), p.1703-1718

2016

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The role of the IT-state in D76N β2-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?

The Journal of biological chemistry, 2020-08, Vol.295 (35), p.12474-12484

2020

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Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2265-2274

2015

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Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

Journal of medicinal chemistry, 2012-04, Vol.55 (7), p.3285-3306

2012

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Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

Oncotarget, 2016-04, Vol.7 (17), p.24252-24268

2016

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Small-Molecule Proteomimetic Inhibitors of the HIF-1α-p300 Protein-Protein Interaction

Chembiochem : a European journal of chemical biology, 2014-05, Vol.15 (8), p.1083-1087

2014

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NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 1

Biomolecular NMR assignments, 2014-04, Vol.8 (1), p.85-88

2014

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Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

Nature communications, 2015-07, Vol.6 (1), p.7877-7877, Article 7877

2015

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The Leishmania PABP1-eIF4E4 interface: a novel 5'-3' interaction architecture for trans-spliced mRNAs

Nucleic acids research, 2019-02, Vol.47 (3), p.1493-1504

2019

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Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

Chemical communications (Cambridge, England), 2016-04, Vol.52 (31), p.5421-5424

2016

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Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System

Structure (London), 2018-03, Vol.26 (3), p.446-458.e8

2018

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Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups

Organic & biomolecular chemistry, 2016-01, Vol.14 (15), p.3782-3786

2016

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Evaluation of 15N-detected H–N correlation experiments on increasingly large RNAs

Journal of biomolecular NMR, 2017-09, Vol.69 (1), p.31-44

2017

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Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies

Molecular bioSystems, 2015-10, Vol.11 (10), p.2738-2749

2015

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EFCAB4B (CRACR2A/Rab46) Genetic Variants Associated with COVID-19 Fatality

COVID, 2024-07, Vol.4 (7), p.1087-1099

2024

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Dimers of D76N-β 2 -microglobulin display potent antiamyloid aggregation activity

The Journal of biological chemistry, 2022-12, Vol.298 (12), p.102659

2022

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Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data

Journal of biomolecular NMR, 2018-05, Vol.71 (1), p.1-9

2018

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Target-Based Whole-Cell Screening by 1H NMR Spectroscopy

Angewandte Chemie (International ed.), 2015-04, Vol.54 (16), p.4764-4767

2015

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Real-Time Monitoring of New Delhi Metallo-β-Lactamase Activity in Living Bacterial Cells by 1H NMR Spectroscopy

Angewandte Chemie (International ed.), 2014-02, Vol.53 (8), p.2130-2133

International ed. in English, 2014

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Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting

Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly

Structural Insights into FGFR Kinase Isoform Selectivity: Diverse Binding Modes of AZD4547 and Ponatinib in Complex with FGFR1 and FGFR4

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

Dimers of D76N-β2-microglobulin display potent antiamyloid aggregation activity

Fragment screening to predict druggability (ligandability) and lead discovery success

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence

The role of the IT-state in D76N β2-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?

Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

Small-Molecule Proteomimetic Inhibitors of the HIF-1α-p300 Protein-Protein Interaction

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 1

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

The Leishmania PABP1-eIF4E4 interface: a novel 5'-3' interaction architecture for trans-spliced mRNAs

Towards "bionic" proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups

Evaluation of 15N-detected H–N correlation experiments on increasingly large RNAs

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies

EFCAB4B (CRACR2A/Rab46) Genetic Variants Associated with COVID-19 Fatality

Dimers of D76N-β 2 -microglobulin display potent antiamyloid aggregation activity

Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data

Target-Based Whole-Cell Screening by 1H NMR Spectroscopy

Real-Time Monitoring of New Delhi Metallo-β-Lactamase Activity in Living Bacterial Cells by 1H NMR Spectroscopy

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