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GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates

Cell metabolism, 2020-12, Vol.32 (6), p.938-950.e6

2020

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Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK

Biochemical and biophysical research communications, 2008-09, Vol.374 (1), p.117-122

2008

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Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network

Nature medicine, 2015-05, Vol.21 (5), p.498-505

2015

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Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15

Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (27), p.1

2021

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Nutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes

Diabetes (New York, N.Y.), 2013-09, Vol.62 (9), p.3005-3013

2013

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Effects of insulin on the vasculature

Current vascular pharmacology, 2011-05, Vol.9 (3), p.321

2011

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Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK

Journal of vascular research, 2020-11, Vol.57 (6), p.325-340

2020

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Pharmacological inhibition of IRAK4 kinase activity does not prevent cachexia in mice with pancreatic cancer

JCSM rapid communications, 2023-07, Vol.6 (2), p.122-133

2023

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Jejunal Leptin-PI3K Signaling Lowers Glucose Production

Cell metabolism, 2014-01, Vol.19 (1), p.155-161

2014

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In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity

Metabolism, clinical and experimental, 2015-02, Vol.64 (2), p.315-322

2015

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Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation

iScience, 2021-06, Vol.24 (6), p.102554-102554, Article 102554

2021

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Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury

Arteriosclerosis, thrombosis, and vascular biology, 2009-07, Vol.29 (7), p.1060

2009

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Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes

Nature medicine, 2012-06, Vol.18 (6), p.950-955

2012

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Characterization of cachexia in the human fibrosarcoma HT‐1080 mouse tumour model

Journal of cachexia, sarcopenia and muscle, 2020-12, Vol.11 (6), p.1813-1829

2020

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Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo

Applied physiology, nutrition, and metabolism, 2015-11, Vol.40 (11), p.1129

2015

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Phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia: PROACC-1 study design

Journal of cachexia, sarcopenia and muscle, 2024-03

2024

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Latest approaches for the treatment of obesity

Expert opinion on drug discovery, 2015-08, Vol.10 (8), p.825-839

2015

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High-dose metformin (420 mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis

Metabolism, clinical and experimental, 2017-03, Vol.68, p.108-118

2017

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The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent

Atherosclerosis, 2015-07, Vol.241 (1), p.111-120

2015

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Lipid sensing in the gut, brain and liver

Trends in endocrinology and metabolism, 2012-02, Vol.23 (2), p.49-55

2012

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Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism

Atherosclerosis, 2012-06, Vol.222 (2), p.375-381

2012

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Duodenal Activation of cAMP-Dependent Protein Kinase Induces Vagal Afferent Firing and Lowers Glucose Production in Rats

Gastroenterology (New York, N.Y. 1943), 2012-04, Vol.142 (4), p.834-843.e3

2012

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Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo

Nutrition & diabetes, 2019-03, Vol.9 (1), p.11-11, Article 11

2019

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Local insulin application on the carotid artery inhibits neointima formation

Canadian journal of physiology and pharmacology, 2013-12, Vol.91 (12), p.1086

2013

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Duodenal PKC-δ and Cholecystokinin Signaling Axis Regulates Glucose Production

Diabetes (New York, N.Y.), 2011-12, Vol.60 (12), p.3148-3153

2011

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GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates

Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network

Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15

Nutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes

Effects of insulin on the vasculature

Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK

Pharmacological inhibition of IRAK4 kinase activity does not prevent cachexia in mice with pancreatic cancer

Jejunal Leptin-PI3K Signaling Lowers Glucose Production

In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity

Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation

Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury

Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes

Characterization of cachexia in the human fibrosarcoma HT‐1080 mouse tumour model

Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo

Phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia: PROACC-1 study design

Latest approaches for the treatment of obesity

High-dose metformin (420 mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis

The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent

Lipid sensing in the gut, brain and liver

Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism

Duodenal Activation of cAMP-Dependent Protein Kinase Induces Vagal Afferent Firing and Lowers Glucose Production in Rats

Pharmacologic or genetic activation of SIRT1 attenuates the fat-induced decrease in beta-cell function in vivo

Local insulin application on the carotid artery inhibits neointima formation

Duodenal PKC-δ and Cholecystokinin Signaling Axis Regulates Glucose Production

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