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GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates

Cell metabolism, 2020-12, Vol.32 (6), p.938-950.e6

2020

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Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK

Biochemical and biophysical research communications, 2008-09, Vol.374 (1), p.117-122

2008

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Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network

Nature medicine, 2015-05, Vol.21 (5), p.498-505

2015

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Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15

Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (27), p.1

2021

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Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes

Nature medicine, 2012-06, Vol.18 (6), p.950-955

2012

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GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss

Cell reports (Cambridge), 2020-04, Vol.31 (3), p.107543-107543, Article 107543

2020

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Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation

Scientific reports, 2021-04, Vol.11 (1), p.8921-12, Article 8921

2021

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GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia

Cell reports (Cambridge), 2023-01, Vol.42 (1), p.111947-111947, Article 111947

2023

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Phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia: PROACC‐1 study design

Journal of cachexia, sarcopenia and muscle, 2024-06, Vol.15 (3), p.1054-1061

2024

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Nutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes

Diabetes (New York, N.Y.), 2013-09, Vol.62 (9), p.3005-3013

2013

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Effects of insulin on the vasculature

Current vascular pharmacology, 2011-05, Vol.9 (3), p.321-332

2011

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Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK

Journal of vascular research, 2020-11, Vol.57 (6), p.325-340

2020

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Latest approaches for the treatment of obesity

Expert opinion on drug discovery, 2015-08, Vol.10 (8), p.825-839

2015

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Characterization of cachexia in the human fibrosarcoma HT‐1080 mouse tumour model

Journal of cachexia, sarcopenia and muscle, 2020-12, Vol.11 (6), p.1813-1829

2020

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Frequency of weight and body composition increases in advanced non-small cell lung cancer patients during first line therapy

Journal of cachexia, sarcopenia and muscle, 2024-09

2024

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Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo

Applied physiology, nutrition, and metabolism, 2015-11, Vol.40 (11), p.1129-1136

2015

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Jejunal Leptin-PI3K Signaling Lowers Glucose Production

Cell metabolism, 2014-01, Vol.19 (1), p.155-161

2014

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Pharmacological inhibition of IRAK4 kinase activity does not prevent cachexia in mice with pancreatic cancer

JCSM rapid communications, 2023-07, Vol.6 (2), p.122-133

2023

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High-dose metformin (420 mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis

Metabolism, clinical and experimental, 2017-03, Vol.68, p.108-118

2017

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In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity

Metabolism, clinical and experimental, 2015-02, Vol.64 (2), p.315-322

2015

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Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation

iScience, 2021-06, Vol.24 (6), p.102554-102554, Article 102554

2021

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The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent

Atherosclerosis, 2015-07, Vol.241 (1), p.111-120

2015

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Lipid sensing in the gut, brain and liver

Trends in endocrinology and metabolism, 2012-02, Vol.23 (2), p.49-55

2012

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Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism

Atherosclerosis, 2012-06, Vol.222 (2), p.375-381

2012

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Duodenal Activation of cAMP-Dependent Protein Kinase Induces Vagal Afferent Firing and Lowers Glucose Production in Rats

Gastroenterology (New York, N.Y. 1943), 2012-04, Vol.142 (4), p.834-843.e3

2012

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GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates

Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK

Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network

Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15

Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes

GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss

Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation

GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia

Phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia: PROACC‐1 study design

Nutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes

Effects of insulin on the vasculature

Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK

Latest approaches for the treatment of obesity

Characterization of cachexia in the human fibrosarcoma HT‐1080 mouse tumour model

Frequency of weight and body composition increases in advanced non-small cell lung cancer patients during first line therapy

Resveratrol prevents insulin resistance caused by short-term elevation of free fatty acids in vivo

Jejunal Leptin-PI3K Signaling Lowers Glucose Production

Pharmacological inhibition of IRAK4 kinase activity does not prevent cachexia in mice with pancreatic cancer

High-dose metformin (420 mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis

In vivo effects of polyunsaturated, monounsaturated, and saturated fatty acids on hepatic and peripheral insulin sensitivity

Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation

The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent

Lipid sensing in the gut, brain and liver

Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism

Duodenal Activation of cAMP-Dependent Protein Kinase Induces Vagal Afferent Firing and Lowers Glucose Production in Rats

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