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UV Signature Mutations

Photochemistry and photobiology, 2015-01, Vol.91 (1), p.15-26

Brash, Douglas E.

2015

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Common contaminants in next-generation sequencing that hinder discovery of low-abundance microbes

PloS one, 2014-05, Vol.9 (5), p.e97876-e97876

2014

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Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure

Science (American Association for the Advancement of Science), 2015-02, Vol.347 (6224), p.842-847

2015

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Genomic sites hypersensitive to ultraviolet radiation

Proceedings of the National Academy of Sciences - PNAS, 2019-11, Vol.116 (48), p.24196-24205

2019

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Chemical excitation of electrons: A dark path to melanoma

DNA repair, 2016-08, Vol.44, p.169-177

2016

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Keratinocyte Apoptosis in Epidermal Development and Disease

Journal of investigative dermatology, 2006-02, Vol.126 (2), p.243-257

2006

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Human telomeres are hypersensitive to UV-induced DNA Damage and refractory to repair

PLoS genetics, 2010-04, Vol.6 (4), p.e1000926

2010

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Defective postreplication repair of UV photoproducts in melanoma: a mutator phenotype

Molecular oncology, 2020-01, Vol.14 (1), p.5-7

2020

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Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia

Proceedings of the National Academy of Sciences - PNAS, 2010-01, Vol.107 (1), p.270-275

2010

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Rethinking Causation for Data-intensive Biology: Constraints, Cancellations, and Quantized Organisms: Causality in complex organisms is sculpted by constraints rather than instigators, with outcomes perhaps better described by quantized patterns than rectilinear pathways

BioEssays, 2020-07, Vol.42 (7), p.e1900135-e1900135

Brash, Douglas E

2020

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Next-generation sequencing methodologies to detect low-frequency mutations: “Catch me if you can”

Mutation research. Reviews in mutation research, 2023-07, Vol.792, p.108471-108471, Article 108471

2023

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UV-induced Melanin Chemiexcitation: A New Mode of Melanoma Pathogenesis

Toxicologic pathology, 2016-06, Vol.44 (4), p.552-554

Brash, Douglas E.

2016

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Triplet-Energy Quenching Functions of Antioxidant Molecules

Antioxidants, 2022-02, Vol.11 (2), p.357

2022

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Melanin Acts as a Potent UVB Photosensitizer to Cause an Atypical Mode of Cell Death in Murine Skin

Proceedings of the National Academy of Sciences - PNAS, 2004-10, Vol.101 (42), p.15076-15081

2004

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Chemiexcitation and melanin in photoreceptor disc turnover and prevention of macular degeneration

Proceedings of the National Academy of Sciences - PNAS, 2023-05, Vol.120 (20), p.e2216935120-e2216935120

2023

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Reply to Pfeffer: Macular degeneration clues from comparative anatomy

Proceedings of the National Academy of Sciences - PNAS, 2023-10, Vol.120 (44), p.e2315582120-e2315582120

2023

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Chemiexcitation: Mammalian Photochemistry in the Dark

Photochemistry and photobiology, 2023-03, Vol.99 (2), p.251-276

2023

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Accelerating cancer without mutations

eLife, 2019-03, Vol.8

Brash, Douglas E

2019

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Cyclobutane Pyrimidine Dimer Hyperhotspots as Sensitive Indicators of Keratinocyte UV Exposure

Photochemistry and photobiology, 2022-09, Vol.98 (5), p.987-997

2022

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Influence of cytosine methylation on ultraviolet-induced cyclobutane pyrimidine dimer formation in genomic DNA

Mutation research, 2009-06, Vol.665 (1), p.7-13

2009

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New Careers for Antioxidants

Proceedings of the National Academy of Sciences - PNAS, 2002-10, Vol.99 (22), p.13969-13971

2002

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Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

Nature genetics, 2012-09, Vol.44 (9), p.1006-1014

2012

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Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death

Molecular cancer therapeutics, 2017-06, Vol.16 (6), p.1092-1101

2017

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Preprocancer

Science (American Association for the Advancement of Science), 2015-05, Vol.348 (6237), p.867-868

Brash, Douglas E

2015

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Escaping the Stem Cell Compartment: Sustained UVB Exposure Allows p53-Mutant Keratinocytes to Colonize Adjacent Epidermal Proliferating Units without Incurring Additional Mutations

Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (24), p.13948-13953

2001

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UV Signature Mutations

Common contaminants in next-generation sequencing that hinder discovery of low-abundance microbes

Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure

Genomic sites hypersensitive to ultraviolet radiation

Chemical excitation of electrons: A dark path to melanoma

Keratinocyte Apoptosis in Epidermal Development and Disease

Human telomeres are hypersensitive to UV-induced DNA Damage and refractory to repair

Defective postreplication repair of UV photoproducts in melanoma: a mutator phenotype

Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia

Rethinking Causation for Data-intensive Biology: Constraints, Cancellations, and Quantized Organisms: Causality in complex organisms is sculpted by constraints rather than instigators, with outcomes perhaps better described by quantized patterns than rectilinear pathways

Next-generation sequencing methodologies to detect low-frequency mutations: “Catch me if you can”

UV-induced Melanin Chemiexcitation: A New Mode of Melanoma Pathogenesis

Triplet-Energy Quenching Functions of Antioxidant Molecules

Melanin Acts as a Potent UVB Photosensitizer to Cause an Atypical Mode of Cell Death in Murine Skin

Chemiexcitation and melanin in photoreceptor disc turnover and prevention of macular degeneration

Reply to Pfeffer: Macular degeneration clues from comparative anatomy

Chemiexcitation: Mammalian Photochemistry in the Dark

Accelerating cancer without mutations

Cyclobutane Pyrimidine Dimer Hyperhotspots as Sensitive Indicators of Keratinocyte UV Exposure

Influence of cytosine methylation on ultraviolet-induced cyclobutane pyrimidine dimer formation in genomic DNA

New Careers for Antioxidants

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death

Preprocancer

Escaping the Stem Cell Compartment: Sustained UVB Exposure Allows p53-Mutant Keratinocytes to Colonize Adjacent Epidermal Proliferating Units without Incurring Additional Mutations

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