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The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

Journal of medicinal chemistry, 2012-07, Vol.55 (14), p.6523-6540

2012

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Rapid Development of Piperidine Carboxamides as Potent and Selective Anaplastic Lymphoma Kinase Inhibitors

Journal of medicinal chemistry, 2012-02, Vol.55 (4), p.1698-1705

2012

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Impact of hydrolysis-mediated clearance on the pharmacokinetics of novel anaplastic lymphoma kinase inhibitors

Drug metabolism and disposition, 2013-01, Vol.41 (1), p.238-247

2013

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NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis

Blood, 2007-11, Vol.110 (10), p.3753-3762

2007

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Comparison of 2 cell-based phosphoprotein assays to support screening and development of an ALK inhibitor

Journal of biomolecular screening, 2011-02, Vol.16 (2), p.164-173

2011

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Cross-contamination with tamoxifen induces transgene expression in non-exposed inducible transgenic mice

Genetics and molecular research, 2004-12, Vol.3 (4), p.456-462

2004

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Specific alternative HOX11 transcripts are expressed in paediatric neural tumours and T-cell acute lymphoblastic leukaemia

Gene, 2003-12, Vol.323, p.89-99

2003

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The functional mapping of long-range transcription control elements of the HOX11 proto-oncogene

Biochemical and biophysical research communications, 2004-01, Vol.313 (2), p.327-335

2004

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Multiple negative elements contribute to repression of the HOX11 proto-oncogene

Oncogene, 1998-10, Vol.17 (14), p.1787-1795

1998

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Abstract C176: The combination of mTORC1/2 and PI3Kα inhibition alleviates PI3K pathway reactivation and leads to significant antitumor activity in multiple preclinical xenograft models

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.C176-C176

2013

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Abstract 1795: Characterization of a novel series of potent, selective inhibitors of wild type and mutant/fusion anaplastic lymphoma kinase

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.1795-1795

2012

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The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

Journal of medicinal chemistry, 2012-07, Vol.55 (14)

2012

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NOTCH 1 pathway activation is an early hallmark of SCL T leukemogenesis

Blood, 2007, Vol.110 (10), p.3753-3762

2007

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A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation

The New England journal of medicine, 2016-10, Vol.375 (17), p.1617-1627

2016

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Use of Social Media as a Platform for Education and Support for People With Diabetes During a Global Pandemic

Journal of diabetes science and technology, 2023-03, Vol.17 (2), p.353-363

2023

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The Long-Term Oxygen Treatment Trial for Chronic Obstructive Pulmonary Disease: Rationale, Design, and Lessons Learned

Annals of the American Thoracic Society, 2018-01, Vol.15 (1), p.89-101

2018

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The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

Rapid Development of Piperidine Carboxamides as Potent and Selective Anaplastic Lymphoma Kinase Inhibitors

Impact of hydrolysis-mediated clearance on the pharmacokinetics of novel anaplastic lymphoma kinase inhibitors

NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis

Comparison of 2 cell-based phosphoprotein assays to support screening and development of an ALK inhibitor

Cross-contamination with tamoxifen induces transgene expression in non-exposed inducible transgenic mice

Specific alternative HOX11 transcripts are expressed in paediatric neural tumours and T-cell acute lymphoblastic leukaemia

The functional mapping of long-range transcription control elements of the HOX11 proto-oncogene

Multiple negative elements contribute to repression of the HOX11 proto-oncogene

Abstract C176: The combination of mTORC1/2 and PI3Kα inhibition alleviates PI3K pathway reactivation and leads to significant antitumor activity in multiple preclinical xenograft models

Abstract 1795: Characterization of a novel series of potent, selective inhibitors of wild type and mutant/fusion anaplastic lymphoma kinase

The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

NOTCH 1 pathway activation is an early hallmark of SCL T leukemogenesis

A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation

Use of Social Media as a Platform for Education and Support for People With Diabetes During a Global Pandemic

The Long-Term Oxygen Treatment Trial for Chronic Obstructive Pulmonary Disease: Rationale, Design, and Lessons Learned

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