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New quinolone antibiotics: a survey of the literature from 2005 to 2010

Expert opinion on therapeutic patents, 2010-10, Vol.20 (10), p.1295-1319

2010

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In Vitro and In Vivo Profiles of ACH-702, an Isothiazoloquinolone, against Bacterial Pathogens

Antimicrobial Agents and Chemotherapy, 2011-06, Vol.55 (6), p.2860-2871

2011

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Recent advances in bacterial topoisomerase inhibitors

Current opinion in pharmacology, 2008-10, Vol.8 (5), p.574-581

2008

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Dual Targeting of DNA Gyrase and Topoisomerase IV: Target Interactions of Heteroaryl Isothiazolones in Staphylococcus aureus

Antimicrobial Agents and Chemotherapy, 2007-07, Vol.51 (7), p.2445-2453

2007

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In Vitro and In Vivo Antibacterial Activities of Heteroaryl Isothiazolones against Resistant Gram-Positive Pathogens

Antimicrobial Agents and Chemotherapy, 2007-04, Vol.51 (4), p.1259-1267

2007

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Selenophene-Containing Inhibitors of Type IIA Bacterial Topoisomerases

Journal of medicinal chemistry, 2011-05, Vol.54 (9), p.3418-3425

2011

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Exploration of the Activity of 7-Pyrrolidino-8-methoxyisothiazoloquinolones against Methicillin-Resistant Staphylococcus aureus (MRSA)

Journal of medicinal chemistry, 2011-05, Vol.54 (9), p.3268-3282

2011

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Small molecule inhibitors of E. coli primase, a novel bacterial target

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (10), p.2807-2810

2007

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Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: Synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1272-1276

2006

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Isothiazoloquinolones with Enhanced Antistaphylococcal Activities against Multidrug-Resistant Strains: Effects of Structural Modifications at the 6-, 7-, and 8-Positions

Journal of medicinal chemistry, 2007-01, Vol.50 (2), p.199-210

2007

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Isothiazolopyridones: Synthesis, Structure, and Biological Activity of a New Class of Antibacterial Agents

Journal of medicinal chemistry, 2006-01, Vol.49 (1), p.39-42

2006

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Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1277-1281

2006

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Practical Synthesis and Molecular Structure of a Potent Broad-Spectrum Antibacterial Isothiazoloquinolone

Organic process research & development, 2007-05, Vol.11 (3), p.389-398

2007

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Functionalized congener approach to muscarinic antagonists: analogs of pirenzepine

Journal of medicinal chemistry, 1991-07, Vol.34 (7), p.2133-2145

1991

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Synthesis and Complement Inhibitory Activity of B/C/D-Ring Analogues of the Fungal Metabolite 6,7-Diformyl-3‘,4‘,4a‘,5‘,6‘,7‘,8‘,8a‘-octahydro-4,6‘,7‘-trihydroxy- 2‘,5‘,5‘,8a‘-tetramethylspiro[1‘(2‘H)-naphthalene-2(3H)-benzofuran]

Journal of medicinal chemistry, 2003-06, Vol.46 (13), p.2697-2705

2003

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Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors

Journal of medicinal chemistry, 1989-08, Vol.32 (8), p.1873-1879

1989

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Muscarinic receptor binding and activation of second messengers by substituted N-methyl-N-[4-(1-azacycloalkyl)-2-butynyl]acetamides

Journal of medicinal chemistry, 1991-03, Vol.34 (3), p.1073-1079

1991

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Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides

Journal of medicinal chemistry, 1990-02, Vol.33 (2), p.741-748

1990

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Mammalian metabolism of phencyclidine

Journal of medicinal chemistry, 1981-06, Vol.24 (6), p.666-669

1981

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Synthesis of substituted spiro (benzofuran-2(3H) - cyclohexanes) as partial derivatives of the complement inhibitor, K-76

Bradbury, Barton J

1988

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Synthesis of 4,7-disubstituted spirobenzofuran-2(3H)-cyclohexanes

Journal of heterocyclic chemistry, 1989-11, Vol.26 (6), p.1827-1833

1989

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Integrated analyses of SNP-genotype and environmental data in a continuously distributed snapper species ( Lutjanus johnii , Bloch, 1792) reveals a mosaic of populations and a challenge for sustainable management

ICES journal of marine science, 2021-11, Vol.78 (9), p.3212-3229

2021

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Study protocol for a randomized controlled trial comparing the efficacy of a specialist and a generic parenting programme for the treatment of preschool ADHD

Trials, 2014-04, Vol.15 (1), p.142-142, Article 142

2014

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An assessment of the coverage of a district-wide diabetic retinopathy screening service

Diabetic medicine, 2005-07, Vol.22 (7), p.840-841

2005

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New quinolone antibiotics: a survey of the literature from 2005 to 2010

In Vitro and In Vivo Profiles of ACH-702, an Isothiazoloquinolone, against Bacterial Pathogens

Recent advances in bacterial topoisomerase inhibitors

Dual Targeting of DNA Gyrase and Topoisomerase IV: Target Interactions of Heteroaryl Isothiazolones in Staphylococcus aureus

In Vitro and In Vivo Antibacterial Activities of Heteroaryl Isothiazolones against Resistant Gram-Positive Pathogens

Selenophene-Containing Inhibitors of Type IIA Bacterial Topoisomerases

Exploration of the Activity of 7-Pyrrolidino-8-methoxyisothiazoloquinolones against Methicillin-Resistant Staphylococcus aureus (MRSA)

Small molecule inhibitors of E. coli primase, a novel bacterial target

Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: Synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells

Isothiazoloquinolones with Enhanced Antistaphylococcal Activities against Multidrug-Resistant Strains: Effects of Structural Modifications at the 6-, 7-, and 8-Positions

Isothiazolopyridones: Synthesis, Structure, and Biological Activity of a New Class of Antibacterial Agents

Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus

Practical Synthesis and Molecular Structure of a Potent Broad-Spectrum Antibacterial Isothiazoloquinolone

Functionalized congener approach to muscarinic antagonists: analogs of pirenzepine

Synthesis and Complement Inhibitory Activity of B/C/D-Ring Analogues of the Fungal Metabolite 6,7-Diformyl-3‘,4‘,4a‘,5‘,6‘,7‘,8‘,8a‘-octahydro-4,6‘,7‘-trihydroxy- 2‘,5‘,5‘,8a‘-tetramethylspiro[1‘(2‘H)-naphthalene-2(3H)-benzofuran]

Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors

Muscarinic receptor binding and activation of second messengers by substituted N-methyl-N-[4-(1-azacycloalkyl)-2-butynyl]acetamides

Functionalized congener approach for the design of novel muscarinic agents. Synthesis and pharmacological evaluation of N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl] amides

Mammalian metabolism of phencyclidine

Synthesis of substituted spiro (benzofuran-2(3H) - cyclohexanes) as partial derivatives of the complement inhibitor, K-76

Synthesis of 4,7-disubstituted spirobenzofuran-2(3H)-cyclohexanes

Integrated analyses of SNP-genotype and environmental data in a continuously distributed snapper species ( Lutjanus johnii , Bloch, 1792) reveals a mosaic of populations and a challenge for sustainable management

Study protocol for a randomized controlled trial comparing the efficacy of a specialist and a generic parenting programme for the treatment of preschool ADHD

An assessment of the coverage of a district-wide diabetic retinopathy screening service

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