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The Role of Allylic Strain for Conformational Control in Medicinal Chemistry

Journal of medicinal chemistry, 2023-06, Vol.66 (12), p.7730-7755

2023

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Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection

Journal of medicinal chemistry, 2019-02, Vol.62 (3), p.1385-1406

2019

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Regio- and Stereoselective Synthesis of Functionalized Cyclopentene Derivatives via Mizoroki–Heck Reactions

Organic letters, 2017-04, Vol.19 (7), p.1602-1605

2017

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Continuous Flow Synthesis under High-Temperature/High-Pressure Conditions Using a Resistively Heated Flow Reactor

Organic process research & development, 2017-07, Vol.21 (7), p.947-955

2017

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Selective Synthesis of Spirooxindoles by an Intramolecular Heck–Mizoroki Reaction

Organic letters, 2017-05, Vol.19 (10), p.2738-2741

2017

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Unexpected Retroaldol-Aldol Reaction during O‑Alkylation of Hydroxylated Vince Lactam Derivatives

Journal of organic chemistry, 2016-01, Vol.81 (2), p.708-714

2016

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Regio- and Stereoselective Synthesis of Spirooxindoles via Mizoroki–Heck Coupling of Aryl Iodides

Synlett, 2019-01, Vol.30 (1), p.82-88

2019

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Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability

Journal of medicinal chemistry, 2016-07, Vol.59 (14), p.6658-6670

2016

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A One-Pot Asymmetric Synthesis of a N‑Acylated 4,5-Dihydropyrazole, A Key Intermediate of Thrombin Inhibitor AZD8165

Organic process research & development, 2014-08, Vol.18 (8), p.969-975

2014

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Total Synthesis of Muconin by Efficient Assembly of Chiral Building Blocks

Journal of organic chemistry, 1998-07, Vol.63 (15), p.4876-4877

1998

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Identification of novel GPR81 agonist lead series for target biology evaluation

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (4), p.126953-126953, Article 126953

2020

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Asymmetric Hetero-Diels−Alder Reactions Catalyzed by Chiral (Salen)Chromium(III) Complexes

Journal of organic chemistry, 1998-01, Vol.63 (2), p.403-405

1998

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Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dioxolan-2-yl]nucleosides as Potential Inhibitors of HIV

Journal of organic chemistry, 1996-05, Vol.61 (11), p.3599-3603

1996

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Synthesis of potential thrombin inhibitors. Incorporation of tartaric acid templates as P2 proline mimetics

Bioorganic & medicinal chemistry, 2002-05, Vol.10 (5), p.1567-1580

2002

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New Proline Mimetics: Synthesis of Thrombin Inhibitors Incorporating Cyclopentane- and Cyclopentenedicarboxylic Acid Templates in the P2 Position. Binding Conformation Investigated by X-ray Crystallography

Journal of medicinal chemistry, 2000-05, Vol.43 (9), p.1705-1713

2000

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Synthesis of [4,5-Bis(hydroxymethyl)-1,3-oxathiolan-2-yl]nucleosides as Potential Inhibitors of HIV via Stereospecific Base-Induced Rearrangement of a 2,3-Epoxy Thioacetate(1)

Journal of organic chemistry, 1996-05, Vol.61 (11), p.3604-3610

1996

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Synthesis of 2',3'-Dideoxy-3'-C-(hydroxymethyl)-4'-thionucleosides as Potential Inhibitors of HIV

Journal of organic chemistry, 1994-04, Vol.59 (7), p.1783-1788

1994

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A convenient synthesis of 1-(S)-[1′-(S)-( t-butyloxycarbonylamino)-2′-phenylethyl]oxirane. A useful building block in the synthesis of HIV protease inhibitors

Tetrahedron letters, 1997-05, Vol.38 (19), p.3483-3486

1997

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Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dithiolan-2-yl]nucleosides as Potential Inhibitors of HIV(1)

Journal of organic chemistry, 1996-05, Vol.61 (11), p.3611-3615

1996

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New Proline Mimetics: Synthesis of Thrombin Inhibitors Incorporating

Journal of medicinal chemistry, 2000, Vol.43, p.1705

2000

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Synthesis of enantiomerically pure cis and trans 2-aminocyclopentanecarboxylic acids. Use of proline replacements in potential HIV-protease inhibitors

Tetrahedron, 1997-06, Vol.53 (23), p.7975-7984

1997

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Synthesis of [4,5-Bis(hydroxymethyl)-1,3-oxathiolan-2-yl]nucleosides as Potential Inhibitors of HIV via Stereospecific Base-Induced Rearrangement of a 2,3-Epoxy Thioacetate1

Journal of organic chemistry, 1996-05, Vol.61 (11), p.3604-3610

1996

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Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dithiolan-2-yl]nucleosides as Potential Inhibitors of HIV1

Journal of organic chemistry, 1996-05, Vol.61 (11), p.3611-3615

1996

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A New Synthesis of 4-Thiofuranosides via Regioselective Opening of an Episulfide with Allylmagnesium Bromide

Journal of organic chemistry, 1994-08, Vol.59 (16), p.4430-4432

1994

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Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dithiolan-2-yl]nucleosides as Potential Inhibitors of HIV 1

Journal of organic chemistry, 1996-01, Vol.61 (11), p.3611-3615

1996

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The Role of Allylic Strain for Conformational Control in Medicinal Chemistry

Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection

Regio- and Stereoselective Synthesis of Functionalized Cyclopentene Derivatives via Mizoroki–Heck Reactions

Continuous Flow Synthesis under High-Temperature/High-Pressure Conditions Using a Resistively Heated Flow Reactor

Selective Synthesis of Spirooxindoles by an Intramolecular Heck–Mizoroki Reaction

Unexpected Retroaldol-Aldol Reaction during O‑Alkylation of Hydroxylated Vince Lactam Derivatives

Regio- and Stereoselective Synthesis of Spirooxindoles via Mizoroki–Heck Coupling of Aryl Iodides

Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability

A One-Pot Asymmetric Synthesis of a N‑Acylated 4,5-Dihydropyrazole, A Key Intermediate of Thrombin Inhibitor AZD8165

Total Synthesis of Muconin by Efficient Assembly of Chiral Building Blocks

Identification of novel GPR81 agonist lead series for target biology evaluation

Asymmetric Hetero-Diels−Alder Reactions Catalyzed by Chiral (Salen)Chromium(III) Complexes

Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dioxolan-2-yl]nucleosides as Potential Inhibitors of HIV

Synthesis of potential thrombin inhibitors. Incorporation of tartaric acid templates as P2 proline mimetics

New Proline Mimetics: Synthesis of Thrombin Inhibitors Incorporating Cyclopentane- and Cyclopentenedicarboxylic Acid Templates in the P2 Position. Binding Conformation Investigated by X-ray Crystallography

Synthesis of [4,5-Bis(hydroxymethyl)-1,3-oxathiolan-2-yl]nucleosides as Potential Inhibitors of HIV via Stereospecific Base-Induced Rearrangement of a 2,3-Epoxy Thioacetate(1)

Synthesis of 2',3'-Dideoxy-3'-C-(hydroxymethyl)-4'-thionucleosides as Potential Inhibitors of HIV

A convenient synthesis of 1-(S)-[1′-(S)-( t-butyloxycarbonylamino)-2′-phenylethyl]oxirane. A useful building block in the synthesis of HIV protease inhibitors

Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dithiolan-2-yl]nucleosides as Potential Inhibitors of HIV(1)

New Proline Mimetics: Synthesis of Thrombin Inhibitors Incorporating

Synthesis of enantiomerically pure cis and trans 2-aminocyclopentanecarboxylic acids. Use of proline replacements in potential HIV-protease inhibitors

Synthesis of [4,5-Bis(hydroxymethyl)-1,3-oxathiolan-2-yl]nucleosides as Potential Inhibitors of HIV via Stereospecific Base-Induced Rearrangement of a 2,3-Epoxy Thioacetate1

Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dithiolan-2-yl]nucleosides as Potential Inhibitors of HIV1

A New Synthesis of 4-Thiofuranosides via Regioselective Opening of an Episulfide with Allylmagnesium Bromide

Synthesis of [4,5-Bis(hydroxymethyl)-1,3-dithiolan-2-yl]nucleosides as Potential Inhibitors of HIV 1

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