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Discovery of 5‑Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors

ACS medicinal chemistry letters, 2023-12, Vol.14 (12), p.1673-1681

2023

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5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties

ACS medicinal chemistry letters, 2016-07, Vol.7 (7), p.666-670

2016

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Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring

Bioorganic & medicinal chemistry letters, 2012-05, Vol.22 (10), p.3392-3397

2012

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Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3156-3161

2006

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Practical Enantioselective Synthesis of β-Substituted-β-amino Esters

Journal of organic chemistry, 2005-07, Vol.70 (14), p.5387-5397

2005

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(−)-Sparteine-Mediated α-Lithiation of N-Boc-N-(p-methoxyphenyl)benzylamine: Enantioselective Syntheses of (S) and (R) Mono- and Disubstituted N-Boc-benzylamines

Journal of the American Chemical Society, 1996-04, Vol.118 (15), p.3757-3758

1996

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Abstract 1635: OKI-1546 is a selective, orally bioavailable inhibitor of CDK12 that causes tumor regression in multiple preclinical cancer models

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1635-1635

2023

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Abstract PO3-25-09: OKI-219, a PI3KαH1047R-mutant-selective inhibitor demonstrates efficacy as a single agent and drives combination responses with standard of care therapies in pre-clinical PI3KαH1047R mutant breast cancer models

Cancer research (Chicago, Ill.), 2024-05, Vol.84 (9_Supplement), p.PO3-25-09-PO3-25-09

2024

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Abstract LB174: OKI-219 is an inhibitor of PI3Kα H1047R that has brain penetrance and anti-tumor activity in a preclinical intracranial model of metastatic breast cancer

Cancer research (Chicago, Ill.), 2024-04, Vol.84 (7_Supplement), p.LB174-LB174

2024

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Abstract B163: Discovery and characterization of OKI-219, an orally bioavailable H1047R-mutant-selective inhibitor of PI3Kα

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.B163-B163

2023

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Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.845-849

2006

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Total Synthesis of (+)-Papuamine: An Antifungal Pentacyclic Alkaloid from a Marine Sponge, Haliclona sp

Journal of organic chemistry, 1996-01, Vol.61 (2), p.685-699

1996

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An activin receptor-like kinase 5 inhibitor reduces collagen deposition in a rat dermal incision wound healing model

Plastic and reconstructive surgery (1963), 2011-11, Vol.128 (5), p.451e-459e

2011

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One-Pot Process for the Preparation of a β-Alkynyl β-Amino Acid Ester

Organic process research & development, 1997-05, Vol.1 (3), p.233-239

1997

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Abstract 551: A potent and selective cFMS inhibitor regulates the tumor macrophage microenvironment leading to tumor growth inhibition

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.551-551

2011

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Preparation of Primary Thioamides From Nitriles Using Sodium Hydrogen Sulfide and Diethylamine Hydrochloride

Synthetic communications, 2006-01, Vol.36 (3), p.295-298

2006

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Abstract 4484: AR-mTOR-26 - A potent, selective mTORC 1/2 kinase inhibitor for the treatment of malignancy

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.4484-4484

2010

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A synthesis of the platelet aggregation inhibitor xemilofiban from L-aspartic acid. Confirmation of the absolute configuration

Tetrahedron letters, 1998-05, Vol.39 (21), p.3449-3450

Boys, Mark L.

1998

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Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3156-3161

2006

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Synthesis of pyrazoles and isoxazoles as potent alpha sub(v) beta sub(3) receptor antagonists

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3156-3161

2006

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Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha(v)beta3 integrin receptor antagonists with improved oral pharmacokinetic properties

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.845-849

2006

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Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha sub(v) beta sub(3) integrin receptor antagonists with improved oral pharmacokinetic properties

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.845-849

2006

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Synthesis of 2,5-thiazole butanoic acids as potent and selective α vβ 3 integrin receptor antagonists with improved oral pharmacokinetic properties

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (4), p.845-849

2006

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Discovery of 5‑Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors

5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties

Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring

Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists

Practical Enantioselective Synthesis of β-Substituted-β-amino Esters

(−)-Sparteine-Mediated α-Lithiation of N-Boc-N-(p-methoxyphenyl)benzylamine: Enantioselective Syntheses of (S) and (R) Mono- and Disubstituted N-Boc-benzylamines

Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective αvβ3 receptor antagonists

Abstract 1635: OKI-1546 is a selective, orally bioavailable inhibitor of CDK12 that causes tumor regression in multiple preclinical cancer models

Abstract PO3-25-09: OKI-219, a PI3KαH1047R-mutant-selective inhibitor demonstrates efficacy as a single agent and drives combination responses with standard of care therapies in pre-clinical PI3KαH1047R mutant breast cancer models

Abstract LB174: OKI-219 is an inhibitor of PI3Kα H1047R that has brain penetrance and anti-tumor activity in a preclinical intracranial model of metastatic breast cancer

Abstract B163: Discovery and characterization of OKI-219, an orally bioavailable H1047R-mutant-selective inhibitor of PI3Kα

Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties

Total Synthesis of (+)-Papuamine: An Antifungal Pentacyclic Alkaloid from a Marine Sponge, Haliclona sp

An activin receptor-like kinase 5 inhibitor reduces collagen deposition in a rat dermal incision wound healing model

One-Pot Process for the Preparation of a β-Alkynyl β-Amino Acid Ester

Abstract 551: A potent and selective cFMS inhibitor regulates the tumor macrophage microenvironment leading to tumor growth inhibition

Preparation of Primary Thioamides From Nitriles Using Sodium Hydrogen Sulfide and Diethylamine Hydrochloride

Abstract 4484: AR-mTOR-26 - A potent, selective mTORC 1/2 kinase inhibitor for the treatment of malignancy

A synthesis of the platelet aggregation inhibitor xemilofiban from L-aspartic acid. Confirmation of the absolute configuration

Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists

Synthesis of pyrazoles and isoxazoles as potent alpha sub(v) beta sub(3) receptor antagonists

Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha(v)beta3 integrin receptor antagonists with improved oral pharmacokinetic properties

Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha sub(v) beta sub(3) integrin receptor antagonists with improved oral pharmacokinetic properties

Synthesis of 2,5-thiazole butanoic acids as potent and selective α vβ 3 integrin receptor antagonists with improved oral pharmacokinetic properties

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