UB Paderborn / Katalog / Suche / in CDI

Sortiert nach

Einfacher Volltextzugriff von (fast) überall

Installieren Sie die LibKey Nomad-Browsererweiterung und erhalten Sie von vielen Webseiten einfachen Zugriff auf lizenzierte Volltexte oder Open Access Publikationen. Mehr erfahren...

Design and Synthesis of Cyclopenta[g]quinazoline-Based Antifolates as Inhibitors of Thymidylate Synthase and Potential Antitumor Agents

Journal of medicinal chemistry, 2000-05, Vol.43 (10), p.1910-1926

2000

Volltextzugriff (PDF)

Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase

Clinical cancer research, 1997-06, Vol.3 (6), p.911-921

1997

Volltextzugriff (PDF)

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

British journal of cancer, 1995-05, Vol.71 (5), p.914-924

1995

Volltextzugriff (PDF)

Design and Synthesis of Potent Non-Polyglutamatable Quinazoline Antifolate Thymidylate Synthase Inhibitors

Journal of medicinal chemistry, 1999-09, Vol.42 (19), p.3809-3820

1999

Volltextzugriff (PDF)

ZD1694 (Tomudex): A new thymidylate synthase inhibitor with activity in colorectal cancer

European journal of cancer (1990), 1995-07, Vol.31 (7), p.1277-1282

1995

Volltextzugriff (PDF)

The renal effects of the water-soluble, non-folylpolyglutamate synthetase-dependent thymidylate synthase inhibitor ZD9331 in mice

British journal of cancer, 1998-12, Vol.78 (11), p.1457-1463

1998

Volltextzugriff (PDF)

Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity

Molecular pharmacology, 1995-09, Vol.48 (3), p.459

1995

Volltextzugriff (PDF)

Quinazoline Antifolates Thymidylate Synthase Inhibitors: Lipophilic Analogues with Modification to the C2-Methyl Substituent

Journal of medicinal chemistry, 1996-02, Vol.39 (3), p.695-704

1996

Volltextzugriff (PDF)

New Mustard Prodrugs for Antibody-Directed Enzyme Prodrug Therapy: Alternatives to the Amide Link

Journal of medicinal chemistry, 1996-03, Vol.39 (5), p.1100-1105

1996

Volltextzugriff (PDF)

Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine

Journal of medicinal chemistry, 2000-11, Vol.43 (22), p.4071

2000

Volltextzugriff (PDF)

Quinazoline Antifolate Thymidylate Synthase Inhibitors: Replacement of Glutamic Acid in the C2-Methyl Series

Journal of medicinal chemistry, 1995-03, Vol.38 (6), p.994-1004

1995

Volltextzugriff (PDF)

Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity

Anti-cancer drug design, 1995-10, Vol.10 (7), p.555

1995

Volltextzugriff (PDF)

The in vivo metabolic stability of dipeptide analogues of the quinazoline antifolate, ICI 198583, in mice

Biochemical pharmacology, 1993-12, Vol.46 (12), p.2229-2234

1993

Volltextzugriff (PDF)

Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation

Anti-cancer drug design, 1995-10, Vol.10 (7), p.573

1995

Volltextzugriff (PDF)

Folate-Based Inhibitors of Thymidylate Synthase: Synthesis and Antitumor Activity of γ-Linked Sterically Hindered Dipeptide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583)

Journal of medicinal chemistry, 1997-05, Vol.40 (10), p.1495-1510

1997

Volltextzugriff (PDF)

Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study

Annals of oncology, 2021-12, Vol.32 (12), p.1571-1581

2021

Volltextzugriff (PDF)

The reduced folate/methotrexate carrier and a membrane-associated folate binding protein as transport routes for novel antifolates: structure-activity relationships

Advances in experimental medicine and biology, 1993, Vol.338, p.767

1993

Volltextzugriff (PDF)

Antitumor effects of an antibody-carboxypeptidase G2 conjugate in combination with a benzoic acid mustard prodrug

Cell biophysics, 1993-01, Vol.22 (1-3), p.1-8

1993

Volltextzugriff (PDF)

Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT)

Anti-cancer drug design, 1996-12, Vol.11 (8), p.625

1996

Volltextzugriff (PDF)

Tomudex (ZD1694): from concept to care, a programme in rational drug discovery

Investigational new drugs, 1996, Vol.14 (3), p.305

1996

Volltextzugriff (PDF)

The role of the reduced-folate carrier and metabolism to intracellular polyglutamates for the activity of ICI D1694

Advances in experimental medicine and biology, 1993, Vol.339, p.265

1993

Volltextzugriff (PDF)

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

The New England journal of medicine, 2011-06, Vol.364 (26), p.2507-2516

2011

Volltextzugriff (PDF)

Antifungal Antibiotics from Calcarisporium thermophilum: A New Source of 15-Azahomosterol Derivatives

Zeitschrift für Naturforschung C. A journal of biosciences, 1990-04, Vol.45 (3), p.179-186

1990

Volltextzugriff (PDF)

Quinazoline Antifolate Thymidylate Synthase Inhibitors: γ-Linked l-d, d-d, and d-l Dipeptide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583)

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.73-85

1996

Volltextzugriff (PDF)

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Nature structural & molecular biology, 2002-10, Vol.9 (10), p.745-749

2002

Volltextzugriff (PDF)

1 – 25 von 4.314

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(3.644)
Mit Volltextzugriff
(3.533)

Publikationsform

4 weitere anzeigen...

Weniger anzeigen...

Sprache

Erscheinungsjahr

n.n

Thema

Science & Technology
(2.435)
Life Sciences & Biomedicine
(1.714)
Humans
(1.276)
Female
(740)
Male
(652)
Biological And Medical Sciences
(612)
Physical Sciences
(526)
Medical Sciences
(478)
Technology
(438)
Adult
(414)
Middle Aged
(399)
Animals
(365)
Aged
(331)
Computer Science
(309)
Computer Science, Artificial Intelligence
(287)
Computer Science, Theory & Methods
(285)
Physics
(208)
Oncology
(204)
Adolescent
(181)
Child
(174)

15 weitere anzeigen...

Weniger anzeigen...

Zeitschrift / Serie

5 weitere anzeigen...

Weniger anzeigen...

Neu hinzugefügt

... seit 30 Tagen
(9)
... seit 90 Tagen
(27)

Menü

Weitere Dienste

Einstellungen

Design and Synthesis of Cyclopenta[g]quinazoline-Based Antifolates as Inhibitors of Thymidylate Synthase and Potential Antitumor Agents

Cellular pharmacology and in vivo activity of a new anticancer agent, ZD9331: a water-soluble, nonpolyglutamatable, quinazoline-based inhibitor of thymidylate synthase

Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines

Design and Synthesis of Potent Non-Polyglutamatable Quinazoline Antifolate Thymidylate Synthase Inhibitors

ZD1694 (Tomudex): A new thymidylate synthase inhibitor with activity in colorectal cancer

The renal effects of the water-soluble, non-folylpolyglutamate synthetase-dependent thymidylate synthase inhibitor ZD9331 in mice

Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity

Quinazoline Antifolates Thymidylate Synthase Inhibitors: Lipophilic Analogues with Modification to the C2-Methyl Substituent

New Mustard Prodrugs for Antibody-Directed Enzyme Prodrug Therapy: Alternatives to the Amide Link

Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine

Quinazoline Antifolate Thymidylate Synthase Inhibitors: Replacement of Glutamic Acid in the C2-Methyl Series

Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity

The in vivo metabolic stability of dipeptide analogues of the quinazoline antifolate, ICI 198583, in mice

Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation

Folate-Based Inhibitors of Thymidylate Synthase: Synthesis and Antitumor Activity of γ-Linked Sterically Hindered Dipeptide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583)

Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study

The reduced folate/methotrexate carrier and a membrane-associated folate binding protein as transport routes for novel antifolates: structure-activity relationships

Antitumor effects of an antibody-carboxypeptidase G2 conjugate in combination with a benzoic acid mustard prodrug

Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT)

Tomudex (ZD1694): from concept to care, a programme in rational drug discovery

The role of the reduced-folate carrier and metabolism to intracellular polyglutamates for the activity of ICI D1694

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Antifungal Antibiotics from Calcarisporium thermophilum: A New Source of 15-Azahomosterol Derivatives

Quinazoline Antifolate Thymidylate Synthase Inhibitors: γ-Linked l-d, d-d, and d-l Dipeptide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583)

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

Suchergebnisse filtern