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MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs

Science advances, 2015-10, Vol.1 (9), p.e1500463-e1500463

2015

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Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity

Cell reports (Cambridge), 2014-05, Vol.7 (3), p.654-660

2014

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Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids

Scientific reports, 2022-04, Vol.12 (1), p.6169-6169, Article 6169

2022

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Bromodomain-Containing Protein 9 Regulates Signaling Pathways and Reprograms the Epigenome in Immortalized Human Uterine Fibroid Cells

International journal of molecular sciences, 2024-01, Vol.25 (2), p.905

2024

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Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

The Journal of biological chemistry, 2018-03, Vol.293 (13), p.4870-4882

2018

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Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

Endocrine reviews, 2022-08, Vol.43 (4), p.678-719

2022

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CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF

The Journal of clinical investigation, 2022-10, Vol.132 (20), p.1-14

2022

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Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network

PLoS genetics, 2021-09, Vol.17 (9), p.e1009785-e1009785

2021

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Basic Helix-Loop-Helix Transcription Factor Twist1 Inhibits Transactivator Function of Master Chondrogenic Regulator Sox9

The Journal of biological chemistry, 2012-06, Vol.287 (25), p.21082-21092

2012

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Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

Cells (Basel, Switzerland), 2024-08, Vol.13 (17), p.1443

2024

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Mediator Modulates Gli3-Dependent Sonic Hedgehog Signaling

Molecular and Cellular Biology, 2006-12, Vol.26 (23), p.8667-8682

2006

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MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling

Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (48), p.19763-19768

2012

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Targeting Class I Histone Deacetylases in Human Uterine Leiomyosarcoma

Cells (Basel, Switzerland), 2022-11, Vol.11 (23), p.3801

2022

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The Functional Role and Regulatory Mechanism of Bromodomain-Containing Protein 9 in Human Uterine Leiomyosarcoma

Cells (Basel, Switzerland), 2022-07, Vol.11 (14), p.2160

2022

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MED19 and MED26 Are Synergistic Functional Targets of the RE1 Silencing Transcription Factor in Epigenetic Silencing of Neuronal Gene Expression

The Journal of biological chemistry, 2009-01, Vol.284 (5), p.2648-2656

2009

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Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (49), p.19678-19682

2011

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CARM1 methylates MED12 to regulate its RNA-binding ability

Life science alliance, 2018-10, Vol.1 (5), p.e201800117-e201800117

2018

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Mediator kinase module and human tumorigenesis

Critical reviews in biochemistry and molecular biology, 2015-01, Vol.50 (5), p.393-426

2015

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MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas

JCI insight, 2023-09, Vol.8 (18)

2023

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Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/β-Catenin Signaling Pathway

Endocrinology (Philadelphia), 2017-03, Vol.158 (3), p.592-603

2017

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Introduction of Somatic Mutation in MED12 Induces Wnt4/β-Catenin and Disrupts Autophagy in Human Uterine Myometrial Cell

Reproductive sciences (Thousand Oaks, Calif.), 2020-03, Vol.27 (3), p.823-832

2020

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Vitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells

The journal of clinical endocrinology and metabolism, 2016-04, Vol.101 (4), p.1542-1551

2016

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Mediator Is a Transducer of Wnt/β-Catenin Signaling

The Journal of biological chemistry, 2006-05, Vol.281 (20), p.14066-14075

2006

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BRCA1 Mediates Ligand-Independent Transcriptional Repression of the Estrogen Receptor

Proceedings of the National Academy of Sciences - PNAS, 2001-08, Vol.98 (17), p.9587-9592

2001

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Transcriptional kinases: Less is more (or less)

Nature chemical biology, 2016-01, Vol.12 (1), p.4

Boyer, Thomas G

2016

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MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs

Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity

Aberrant R-loop-induced replication stress in MED12-mutant uterine fibroids

Bromodomain-Containing Protein 9 Regulates Signaling Pathways and Reprograms the Epigenome in Immortalized Human Uterine Fibroid Cells

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19

Comprehensive Review of Uterine Fibroids: Developmental Origin, Pathogenesis, and Treatment

CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF

Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network

Basic Helix-Loop-Helix Transcription Factor Twist1 Inhibits Transactivator Function of Master Chondrogenic Regulator Sox9

Unraveling the Role of Bromodomain and Extra-Terminal Proteins in Human Uterine Leiomyosarcoma

Mediator Modulates Gli3-Dependent Sonic Hedgehog Signaling

MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling

Targeting Class I Histone Deacetylases in Human Uterine Leiomyosarcoma

The Functional Role and Regulatory Mechanism of Bromodomain-Containing Protein 9 in Human Uterine Leiomyosarcoma

MED19 and MED26 Are Synergistic Functional Targets of the RE1 Silencing Transcription Factor in Epigenetic Silencing of Neuronal Gene Expression

Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet

CARM1 methylates MED12 to regulate its RNA-binding ability

Mediator kinase module and human tumorigenesis

MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas

Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/β-Catenin Signaling Pathway

Introduction of Somatic Mutation in MED12 Induces Wnt4/β-Catenin and Disrupts Autophagy in Human Uterine Myometrial Cell

Vitamin D3 Inhibits Wnt/β-Catenin and mTOR Signaling Pathways in Human Uterine Fibroid Cells

Mediator Is a Transducer of Wnt/β-Catenin Signaling

BRCA1 Mediates Ligand-Independent Transcriptional Repression of the Estrogen Receptor

Transcriptional kinases: Less is more (or less)

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