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Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase

Journal of virology, 2018-07, Vol.92 (13)

2018

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HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors

Journal of Virology, 2012-05, Vol.86 (10), p.5885-5894

2012

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Structural basis of HIV-1 resistance to AZT by excision

Nature structural & molecular biology, 2010-10, Vol.17 (10), p.1202-1209

2010

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Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)

Viruses, 2021-07, Vol.13 (8), p.1495

2021

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Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

The Journal of biological chemistry, 2009-12, Vol.284 (50), p.35092-35100

2009

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Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

Nature structural & molecular biology, 2004-05, Vol.11 (5), p.469-474

2004

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HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (31), p.10943-10948

2008

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Synthesis and Biological Activity of Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2-Aryl-Substituted Benzimidazoles

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4199-4207

1997

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The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance

Journal of molecular biology, 2001-06, Vol.309 (2), p.437-445

2001

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Foamy Retrovirus Integrase Contains a Pol Dimerization Domain Required for Protease Activation

Journal of Virology, 2011-02, Vol.85 (4), p.1655-1661

2011

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Nucleoside Analog Resistance Caused by Insertions in the Fingers of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involves ATP-Mediated Excision

Journal of Virology, 2002-09, Vol.76 (18), p.9143-9151

2002

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Fixed Conformation Nucleoside Analogs Effectively Inhibit Excision-proficient HIV-1 Reverse Transcriptases

Journal of molecular biology, 2005-01, Vol.345 (3), p.441-450

2005

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The M184V Mutation Reduces the Selective Excision of Zidovudine 5′-Monophosphate (AZTMP) by the Reverse Transcriptase of Human Immunodeficiency Virus Type 1

Journal of Virology, 2002-04, Vol.76 (7), p.3248-3256

2002

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Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase

Antimicrobial agents and chemotherapy, 2015-12, Vol.59 (12), p.7184-7196

2015

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4′-C-Methyl-2′-Deoxyadenosine and 4′-C-Ethyl-2′-Deoxyadenosine Inhibit HIV-1 Replication

Antimicrobial Agents and Chemotherapy, 2011-05, Vol.55 (5), p.2379-2389

2011

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A Combination of Amino Acid Mutations Leads to Resistance to Multiple Nucleoside Analogs in Reverse Transcriptases from HIV-1 Subtypes B and C

Antimicrobial agents and chemotherapy, 2022-01, Vol.66 (1), p.e0150021

2022

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Apparent Defects in Processive DNA Synthesis, Strand Transfer, and Primer Elongation of Met-184 Mutants of HIV-1 Reverse Transcriptase Derive Solely from a dNTP Utilization Defect

The Journal of biological chemistry, 2008-04, Vol.283 (14), p.9196-9205

2008

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Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs

Journal of virology, 2019-06, Vol.93 (11)

2019

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4‑Amino-1-hydroxy-2-oxo-1,8-naphthyridine-Containing Compounds Having High Potency against Raltegravir-Resistant Integrase Mutants of HIV‑1

Journal of medicinal chemistry, 2014-06, Vol.57 (12), p.5190-5202

2014

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Trapping HIV-1 Reverse Transcriptase Before and After Translocation on DNA

The Journal of biological chemistry, 2003-05, Vol.278 (18), p.16280-16288

2003

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Effects of the Δ67 Complex of Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Nucleoside Analog Excision

Journal of Virology, 2004-09, Vol.78 (18), p.9987-9997

2004

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Characterization of the Polymerase and RNase H Activities of Human Foamy Virus Reverse Transcriptase

Journal of Virology, 2004-06, Vol.78 (12), p.6112-6121

2004

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D-(+)-iso-Methanocarbathymidine: a High-Affinity Substrate for Herpes Simplex Virus 1 Thymidine Kinase

ChemMedChem, 2008-07, Vol.3 (7), p.1129-1134

2008

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Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

The EMBO journal, 2001-03, Vol.20 (6), p.1449-1461

2001

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Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase

HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase Inhibitors

Structural basis of HIV-1 resistance to AZT by excision

Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)

Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision

Synthesis and Biological Activity of Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2-Aryl-Substituted Benzimidazoles

The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance

Foamy Retrovirus Integrase Contains a Pol Dimerization Domain Required for Protease Activation

Nucleoside Analog Resistance Caused by Insertions in the Fingers of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involves ATP-Mediated Excision

Fixed Conformation Nucleoside Analogs Effectively Inhibit Excision-proficient HIV-1 Reverse Transcriptases

The M184V Mutation Reduces the Selective Excision of Zidovudine 5′-Monophosphate (AZTMP) by the Reverse Transcriptase of Human Immunodeficiency Virus Type 1

Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase

4′-C-Methyl-2′-Deoxyadenosine and 4′-C-Ethyl-2′-Deoxyadenosine Inhibit HIV-1 Replication

A Combination of Amino Acid Mutations Leads to Resistance to Multiple Nucleoside Analogs in Reverse Transcriptases from HIV-1 Subtypes B and C

Apparent Defects in Processive DNA Synthesis, Strand Transfer, and Primer Elongation of Met-184 Mutants of HIV-1 Reverse Transcriptase Derive Solely from a dNTP Utilization Defect

Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs

4‑Amino-1-hydroxy-2-oxo-1,8-naphthyridine-Containing Compounds Having High Potency against Raltegravir-Resistant Integrase Mutants of HIV‑1

Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants

Trapping HIV-1 Reverse Transcriptase Before and After Translocation on DNA

Effects of the Δ67 Complex of Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Nucleoside Analog Excision

Characterization of the Polymerase and RNase H Activities of Human Foamy Virus Reverse Transcriptase

D-(+)-iso-Methanocarbathymidine: a High-Affinity Substrate for Herpes Simplex Virus 1 Thymidine Kinase

Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

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