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In Vitro-In Vivo Extrapolation and Hepatic Clearance-Dependent Underprediction

Journal of pharmaceutical sciences, 2019-07, Vol.108 (7), p.2500-2504

2019

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The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation

Drug metabolism and disposition, 2019-04, Vol.47 (4), p.358-363

2019

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An Exceptionally Potent Inhibitor of Human CD73

Biochemistry (Easton), 2019-08, Vol.58 (31), p.3331-3334

2019

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Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling

Drug metabolism and disposition, 2021-07, Vol.49 (7), p.530-539

2021

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Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System

Drug metabolism and disposition, 2016-11, Vol.44 (11), p.1731-1735

2016

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Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties

Pharmaceutical research, 2019-08, Vol.36 (8), p.113-8, Article 113

2019

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In Vitro-In Vivo Inaccuracy: The CYP3A4 Anomaly

Drug metabolism and disposition, 2019-12, Vol.47 (12), p.1368-1371

2019

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The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses

Pharmaceutical research, 2018-12, Vol.35 (12), p.242-12, Article 242

2018

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How Transporters Have Changed Basic Pharmacokinetic Understanding

The AAPS journal, 2019-09, Vol.21 (6), p.103-103, Article 103

2019

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Changes in Organic Anion Transporting Polypeptide Uptake in HEK293 Overexpressing Cells in the Presence and Absence of Human Plasma

Drug metabolism and disposition, 2020-01, Vol.48 (1), p.18-24

2020

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General Base–General Acid Catalysis in Human Histone Deacetylase 8

Biochemistry (Easton), 2016-02, Vol.55 (5), p.820-832

2016

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Examination of Physiologically‐Based Pharmacokinetic Models of Rosuvastatin

CPT: pharmacometrics and systems pharmacology, 2021-01, Vol.10 (1), p.5-17

2021

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Characterization of AB598, a CD39 Enzymatic Inhibitory Antibody for the Treatment of Solid Tumors

Molecular cancer therapeutics, 2024-05

2024

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Understanding CYP3A4 and P-GP mediated drug-drug interactions through PBPK modeling - case example of pralsetinib

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100969, Article 100969

2024

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Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders

Biochemistry (Easton), 2015-10, Vol.54 (42), p.6501-6513

2015

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Continuing Delay in the Diagnosis of Slipped Capital Femoral Epiphysis

The Journal of pediatrics, 2016-10, Vol.177, p.250-254

2016

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Extremity Pressure in Splints Wrapped With an Elastic Bandage Versus Bias Cut Stockinette: An Experimental Model

Hand (New York, N.Y.), 2024-05, Vol.19 (3), p.488-492

2024

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How does specialist nursing contribute to HIV service delivery across England?

International journal of STD & AIDS, 2017-07, Vol.28 (8), p.808-813

2017

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Understanding CYP3A4 and P‐gp mediated drug–drug interactions through PBPK modeling – Case example of pralsetinib

CPT: pharmacometrics and systems pharmacology, 2024-04, Vol.13 (4), p.660-672

2024

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Treatment Trends in Pediatric Trigger Thumb Among Hand Surgeons, Pediatric Orthopedic Surgeons, and Pediatric Hand Surgeons

Hand (New York, N.Y.), 2023-11, p.15589447231210925-15589447231210925

2023

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Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders

ACS chemical biology, 2014-09, Vol.9 (9), p.2157-2164

2014

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Synthesis and evaluation of N8-acetylspermidine analogues as inhibitors of bacterial acetylpolyamine amidohydrolase

Bioorganic & medicinal chemistry, 2013-08, Vol.21 (15), p.4530-4540

2013

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The contribution of the HIV specialist nurse to HIV care: a scoping review

Journal of clinical nursing, 2013-12, Vol.22 (23-24), p.3349-3360

2013

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Use of an Accelerated Discharge Pathway in Patients With Severe Cerebral Palsy Undergoing Posterior Spinal Fusion for Neuromuscular Scoliosis

Spine deformity, 2019-09, Vol.7 (5), p.804-811

2019

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In Vitro-In Vivo Extrapolation and Hepatic Clearance-Dependent Underprediction

The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation

An Exceptionally Potent Inhibitor of Human CD73

Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling

Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System

Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial

Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties

In Vitro-In Vivo Inaccuracy: The CYP3A4 Anomaly

The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses

How Transporters Have Changed Basic Pharmacokinetic Understanding

Changes in Organic Anion Transporting Polypeptide Uptake in HEK293 Overexpressing Cells in the Presence and Absence of Human Plasma

General Base–General Acid Catalysis in Human Histone Deacetylase 8

Examination of Physiologically‐Based Pharmacokinetic Models of Rosuvastatin

Characterization of AB598, a CD39 Enzymatic Inhibitory Antibody for the Treatment of Solid Tumors

Understanding CYP3A4 and P-GP mediated drug-drug interactions through PBPK modeling - case example of pralsetinib

Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders

Continuing Delay in the Diagnosis of Slipped Capital Femoral Epiphysis

Extremity Pressure in Splints Wrapped With an Elastic Bandage Versus Bias Cut Stockinette: An Experimental Model

How does specialist nursing contribute to HIV service delivery across England?

Understanding CYP3A4 and P‐gp mediated drug–drug interactions through PBPK modeling – Case example of pralsetinib

Treatment Trends in Pediatric Trigger Thumb Among Hand Surgeons, Pediatric Orthopedic Surgeons, and Pediatric Hand Surgeons

Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders

Synthesis and evaluation of N8-acetylspermidine analogues as inhibitors of bacterial acetylpolyamine amidohydrolase

The contribution of the HIV specialist nurse to HIV care: a scoping review

Use of an Accelerated Discharge Pathway in Patients With Severe Cerebral Palsy Undergoing Posterior Spinal Fusion for Neuromuscular Scoliosis

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