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Assessment of cardiomyocyte contraction in human-induced pluripotent stem cell-derived cardiomyocytes

Toxicological sciences, 2015-04, Vol.144 (2), p.227-237

2015

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Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes

Toxicology in vitro, 2014-03, Vol.28 (2), p.171-181

2014

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MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity

Toxicological sciences, 2015-03, Vol.144 (1), p.173-185

2015

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Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

Nature reviews. Drug discovery, 2012-12, Vol.11 (12), p.909-922

2012

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Inhibition of the Activity of Poly (ADP Ribose) Synthetase Reduces Ischemia--Reperfusion Injury in the Heart and Skeletal Muscle

Proceedings of the National Academy of Sciences - PNAS, 1997-01, Vol.94 (2), p.679-683

1997

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Use of an Esophageal Heat Exchanger to Maintain Core Temperature during Burn Excisions and to Attenuate Pyrexia on the Burns Intensive Care Unit

Case reports in anesthesiology, 2016-01, Vol.2016, p.7306341-6

2016

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Inhibitors of the activity of poly (ADP‐ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts

British journal of pharmacology, 1998-08, Vol.124 (8), p.1760-1766

1998

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An inhibitor of poly (ADP‐ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart

British journal of pharmacology, 1999-07, Vol.127 (6), p.1518-1524

1999

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Interpretation of in vitro pharmacological profiling data in preclinical safety assessment

Journal of pharmacological and toxicological methods, 2014-11, Vol.70 (3), p.323-323

2014

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Development of a hERG trafficking inhibitor screen

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.165-165

2012

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Correlation of in vitro screening technologies for secondary pharmacodynamic assessment

Journal of pharmacological and toxicological methods, 2014-11, Vol.70 (3), p.320-320

2014

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Acetylcholinesterase: Is there a recommended level of off target activity that can be tolerated and predicted safe?

Journal of pharmacological and toxicological methods, 2014-11, Vol.70 (3), p.327-327

2014

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Secondary pharmacology: Case studies of integration with safety pharmacology data

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e17-e18

2011

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Development of an in vitro screen of neurite outgrowth to predict drug-induced neurotoxicity

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.192-192

2012

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Mechanistic understanding of drug-induced mitochondrial toxicity using isolated mitochondrial complex assays

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.165-165

2012

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A comprehensive assessment of cardiovascular risk in telemetered cynomolgus monkeys

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.186-186

2012

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Predictive secondary pharmacology: Concepts and application to drug discovery

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e17-e17

2011

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Cardiac contractility strategy: A case study using early preclinical models

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e29-e29

2011

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Tempol reduces infarct size in rodent models of regional myocardial ischemia and reperfusion

Free radical biology & medicine, 1999-09, Vol.27 (5), p.493-503

1999

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Rational design of an in vitro safety profiling panel to reduce undesired secondary pharmacology of drug candidates

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e18-e18

2011

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Development and application of Rat and human screens for AhR activators/CYP1A inducers

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e13-e13

2011

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Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress

Cardiovascular research, 1999, Vol.41 (1), p.126-134

1999

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Effects of inhibitors of the activity of poly (ADP‐ribose) synthetase on the liver injury caused by ischaemia‐reperfusion: a comparison with radical scavengers

British journal of pharmacology, 1998-07, Vol.124 (6), p.1254-1260

1998

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Development of a phospholipidosis screen: Comparison of a rat hepatoma cell line with rat isolated hepatocytes

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e12-e12

2011

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The L-type calcium channel: A comparison of automated electrophysiological and ligand-binding data, and prediction of in vivo effects

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e5-e6

2011

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Assessment of cardiomyocyte contraction in human-induced pluripotent stem cell-derived cardiomyocytes

Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes

MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

Inhibition of the Activity of Poly (ADP Ribose) Synthetase Reduces Ischemia--Reperfusion Injury in the Heart and Skeletal Muscle

Use of an Esophageal Heat Exchanger to Maintain Core Temperature during Burn Excisions and to Attenuate Pyrexia on the Burns Intensive Care Unit

Inhibitors of the activity of poly (ADP‐ribose) synthetase reduce the cell death caused by hydrogen peroxide in human cardiac myoblasts

An inhibitor of poly (ADP‐ribose) synthetase activity reduces contractile dysfunction and preserves high energy phosphate levels during reperfusion of the ischaemic rat heart

Interpretation of in vitro pharmacological profiling data in preclinical safety assessment

Development of a hERG trafficking inhibitor screen

Correlation of in vitro screening technologies for secondary pharmacodynamic assessment

Acetylcholinesterase: Is there a recommended level of off target activity that can be tolerated and predicted safe?

Secondary pharmacology: Case studies of integration with safety pharmacology data

Development of an in vitro screen of neurite outgrowth to predict drug-induced neurotoxicity

Mechanistic understanding of drug-induced mitochondrial toxicity using isolated mitochondrial complex assays

A comprehensive assessment of cardiovascular risk in telemetered cynomolgus monkeys

Predictive secondary pharmacology: Concepts and application to drug discovery

Cardiac contractility strategy: A case study using early preclinical models

Tempol reduces infarct size in rodent models of regional myocardial ischemia and reperfusion

Rational design of an in vitro safety profiling panel to reduce undesired secondary pharmacology of drug candidates

Development and application of Rat and human screens for AhR activators/CYP1A inducers

Inhibitors of poly (ADP-ribose) synthetase protect rat cardiomyocytes against oxidant stress

Effects of inhibitors of the activity of poly (ADP‐ribose) synthetase on the liver injury caused by ischaemia‐reperfusion: a comparison with radical scavengers

Development of a phospholipidosis screen: Comparison of a rat hepatoma cell line with rat isolated hepatocytes

The L-type calcium channel: A comparison of automated electrophysiological and ligand-binding data, and prediction of in vivo effects

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