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Humanized Mouse Models for Immuno‐oncology Drug Discovery

Current protocols, 2023-08, Vol.3 (8), p.e852-n/a

2023

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Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

Frontiers in immunology, 2024-02, Vol.15, p.1357716-1357716

2024

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5-Aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy

Molecular cancer therapeutics, 2008-06, Vol.7 (6), p.1720-1729

2008

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Effective photoinactivation of Gram-positive and Gram-negative bacterial strains using an HIV-1 Tat peptide-porphyrin conjugate

Photochemical & photobiological sciences, 2010-12, Vol.9 (12), p.1613-162

2010

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Improved Peptide Prodrugs of 5-ALA for PDT: Rationalization of Cellular Accumulation and Protoporphyrin IX Production by Direct Determination of Cellular Prodrug Uptake and Prodrug Metabolization

Journal of medicinal chemistry, 2009-07, Vol.52 (13), p.4026-4037

2009

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Indirect detection of photosensitizer ex vivo

Journal of photochemistry and photobiology. B, Biology, 2002-05, Vol.67 (1), p.23-31

2002

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Novel prodrug approach to photodynamic therapy: Fmoc solid-phase synthesis of a cell permeable peptide incorporating 5-aminolaevulinic acid

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4518-4522

2007

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Quantitative determination of 5-aminolaevulinic acid and its esters in cell lysates by HPLC-fluorescence

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-11, Vol.875 (2), p.562-566

2008

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1119 Selective reversal of key features of T cell exhaustion in an in vitro model by a SMARCA4/2 ATPase inhibitor

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A1232-A1232

2023

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447 Evaluation of efficacy and toxicity of human CD40 agonistic antibodies in C57BL/6-hCD40/hFcγRIIB HuGEMMTM

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A497-A497

2023

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Abstract 3110: Identification of the phosphorylation network in PDX and corresponding organoid (PDXO) models upon targeted therapy treatment using deep phosphoproteomic analysis[MB1]

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.3110-3110

2022

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Results of a first-in-human phase I study of INVAC-1, an optimized plasmid DNA encoding an inactive form of human telomerase reverse transcriptase (hTERT), in patients with advanced solid tumors

Journal of clinical oncology, 2017-05, Vol.35 (15_suppl), p.3087-3087

2017

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908 Humanized model for assessment of therapies targeting either lymphoid or myeloid compartment: enhanced evaluation of clinical relevancy & translatability

Journal for immunotherapy of cancer, 2021-11, Vol.9 (Suppl 2), p.A953-A953

2021

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Abstract 185: Global mapping of pathway modules and phosphorylation networks in PDX and corresponding organoid (PDXO) models treated with targeted therapies

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.185-185

2023

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Enhancement of Delta Aminolevulinic Acid-Photodynamic Therapy In Vivo by Decreasing Tumor pH With Glucose and Amiloride

The Laryngoscope, 2001-12, Vol.111 (12), p.2205-2213

2001

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Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?

Biotechnology advances, 2011-07, Vol.29 (4), p.402-417

2011

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Cellular distribution and phototoxicity of benzoporphyrin derivative and Photofrin

Research in experimental medicine, 2000-06, Vol.199 (6), p.341-357

2000

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Abstract LB435: Large panel organoid drug testing combined with biomarker analysis: Unveiling prospects for mechanism of action identification and preclinical patient stratification

Cancer research (Chicago, Ill.), 2024-04, Vol.84 (7_Supplement), p.LB435-LB435

2024

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Abstract 538: Establishment of PARP inhibitor-induced resistant patient-derived ovarian cancer xenograft models

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.538-538

2024

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Abstract 1942: Characterization of a panel of CRISPR/Cas9 engineered KRAS G12C inhibitor-resistant tumor models

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.1942-1942

2024

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Abstract 2827: Characterization of acute myeloid leukemia PDX models with hotspot gene mutations for therapeutic evaluation

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.2827-2827

2024

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Abstract 5264: KRASG12C inhibition synergizes with checkpoint blockade in KRASG12C-mutated tumor model

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.5264-5264

2024

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Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models

Drug discovery today, 2011-03, Vol.16 (5), p.203-218

2011

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Abstract A006: Characterizing antitumor response of PARP inhibitor and synergy of docetaxel and PARP Inhibitor in BRCA1/2 mutant TNBC breast cancer PDX models

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.A006-A006

2023

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Humanized Mouse Models for Immuno‐oncology Drug Discovery

Myeloid and dendritic cells enhance therapeutics-induced cytokine release syndrome features in humanized BRGSF-HIS preclinical model

5-Aminolaevulinic acid peptide prodrugs enhance photosensitization for photodynamic therapy

Effective photoinactivation of Gram-positive and Gram-negative bacterial strains using an HIV-1 Tat peptide-porphyrin conjugate

Improved Peptide Prodrugs of 5-ALA for PDT: Rationalization of Cellular Accumulation and Protoporphyrin IX Production by Direct Determination of Cellular Prodrug Uptake and Prodrug Metabolization

Indirect detection of photosensitizer ex vivo

Novel prodrug approach to photodynamic therapy: Fmoc solid-phase synthesis of a cell permeable peptide incorporating 5-aminolaevulinic acid

Quantitative determination of 5-aminolaevulinic acid and its esters in cell lysates by HPLC-fluorescence

1119 Selective reversal of key features of T cell exhaustion in an in vitro model by a SMARCA4/2 ATPase inhibitor

447 Evaluation of efficacy and toxicity of human CD40 agonistic antibodies in C57BL/6-hCD40/hFcγRIIB HuGEMMTM

INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death

Abstract 3110: Identification of the phosphorylation network in PDX and corresponding organoid (PDXO) models upon targeted therapy treatment using deep phosphoproteomic analysis[MB1]

Results of a first-in-human phase I study of INVAC-1, an optimized plasmid DNA encoding an inactive form of human telomerase reverse transcriptase (hTERT), in patients with advanced solid tumors

908 Humanized model for assessment of therapies targeting either lymphoid or myeloid compartment: enhanced evaluation of clinical relevancy & translatability

Abstract 185: Global mapping of pathway modules and phosphorylation networks in PDX and corresponding organoid (PDXO) models treated with targeted therapies

Enhancement of Delta Aminolevulinic Acid-Photodynamic Therapy In Vivo by Decreasing Tumor pH With Glucose and Amiloride

Can non-viral technologies knockdown the barriers to siRNA delivery and achieve the next generation of cancer therapeutics?

Cellular distribution and phototoxicity of benzoporphyrin derivative and Photofrin

Abstract LB435: Large panel organoid drug testing combined with biomarker analysis: Unveiling prospects for mechanism of action identification and preclinical patient stratification

Abstract 538: Establishment of PARP inhibitor-induced resistant patient-derived ovarian cancer xenograft models

Abstract 1942: Characterization of a panel of CRISPR/Cas9 engineered KRAS G12C inhibitor-resistant tumor models

Abstract 2827: Characterization of acute myeloid leukemia PDX models with hotspot gene mutations for therapeutic evaluation

Abstract 5264: KRASG12C inhibition synergizes with checkpoint blockade in KRASG12C-mutated tumor model

Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models

Abstract A006: Characterizing antitumor response of PARP inhibitor and synergy of docetaxel and PARP Inhibitor in BRCA1/2 mutant TNBC breast cancer PDX models

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