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Weight and Glucose Reduction Observed with a Combination of Nutritional Agents in Rodent Models Does Not Translate to Humans in a Randomized Clinical Trial with Healthy Volunteers and Subjects with Type 2 Diabetes

PloS one, 2016-04, Vol.11 (4), p.e0153151-e0153151

2016

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Synthesis and evaluation of novel heterocyclic inhibitors of GSK-3

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (8), p.2091-2094

2006

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N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as Potent and Selective Inhibitors of Glycogen Synthase Kinase 3 with Good Cellular Efficacy

Journal of medicinal chemistry, 2004-09, Vol.47 (19), p.4716-4730

2004

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Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2121-2125

2004

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Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (4), p.1177-1182

2009

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Novel GSK-3 inhibitors with improved cellular activity

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2127-2130

2004

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Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4068-4071

2008

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Regulation of Ingestive Behaviors in the Rat by GSK1521498, a Novel μ-Opioid Receptor-Selective Inverse Agonist

The Journal of pharmacology and experimental therapeutics, 2011-10, Vol.339 (1), p.24-34

2011

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Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

Cancer research (Chicago, Ill.), 1986-03, Vol.46 (3), p.1280-1284

1986

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P2U Agonists Induce Chemotaxis and Actin Polymerization in Human Neutrophils and Differentiated HL60 Cells

The Journal of biological chemistry, 1996-06, Vol.271 (26), p.15597-15601

1996

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High- to Low-Dose Extrapolation: Critical Determinants Involved in the Dose Response of Carcinogenic Substances

Environmental Health Perspectives [ENVIRON. HEALTH PERSPECT.]. 1987, 1987-12, Vol.76, p.57-63

1987

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POSTERS: INSULIN ACTION-METABOLISM

Diabetes (New York, N.Y.), 2004-06, Vol.53, p.A319

2004

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Biochemical and morphologic studies of heterogeneous lobe responses in hepatocarcinogenesis

Carcinogenesis (New York), 1986, Vol.7 (2), p.247-251

1986

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Hepatocyte initiation during continuous administration of diethylnitrosamine and 1,2-sym-dimethylhydrazine

Cancer research (Chicago, Ill.), 1988-02, Vol.48 (4), p.988-992

1988

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Regulation of ingestive behaviors in the rat by GSK1521498, a novel micro-opioid receptor-selective inverse agonist

The Journal of pharmacology and experimental therapeutics, 2011-10, Vol.339 (1), p.24

2011

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Relationships between DNA Adduct Formation and Carcinogenesis

Environmental health perspectives, 1985-10, Vol.62, p.177-183

1985

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Molecular dosimetry of O4-ethyldeoxythymidine in rats continuously exposed to diethylnitrosamine

Cancer research (Chicago, Ill.), 1987-03, Vol.47 (6), p.1577

1987

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Differential repair of O4-alkylthymidine following exposure to methylating and ethylating hepatocarcinogens

Carcinogenesis (New York), 1985-04, Vol.6 (4), p.625-629

1985

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Differential repair of O 4 -alkylthymidine following exposure to methylating and ethylating hepatocarcinogens

Carcinogenesis (New York), 1985, Vol.6 (4), p.625-629

1985

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Novel GSK-3 Inhibitor with Improved Cellular Activity

ChemInform, 2004-08, Vol.35 (35), p.no-no

2004

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Macromolecular adducts of ethylene oxide: a literature review and a time-course study on the formation of 7-(2-hydroxyethyl)guanine following exposures of rats by inhalation

Mutation research, 1990-11, Vol.233 (1-2), p.151-164

1990

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Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models

PloS one, 2015-12, Vol.10 (12), p.e0145499-e0145499

2015

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Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis

Experimental and therapeutic medicine, 2012-10, Vol.4 (4), p.594-604

2012

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Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models: e0145499

PloS one, 2015-12, Vol.10 (12)

2015

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Weight and Glucose Reduction Observed with a Combination of Nutritional Agents in Rodent Models Does Not Translate to Humans in a Randomized Clinical Trial with Healthy Volunteers and Subjects with Type 2 Diabetes

Synthesis and evaluation of novel heterocyclic inhibitors of GSK-3

N-Phenyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amines as Potent and Selective Inhibitors of Glycogen Synthase Kinase 3 with Good Cellular Efficacy

Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors

Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy

Novel GSK-3 inhibitors with improved cellular activity

Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors

Regulation of Ingestive Behaviors in the Rat by GSK1521498, a Novel μ-Opioid Receptor-Selective Inverse Agonist

Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone

P2U Agonists Induce Chemotaxis and Actin Polymerization in Human Neutrophils and Differentiated HL60 Cells

High- to Low-Dose Extrapolation: Critical Determinants Involved in the Dose Response of Carcinogenic Substances

POSTERS: INSULIN ACTION-METABOLISM

Biochemical and morphologic studies of heterogeneous lobe responses in hepatocarcinogenesis

Hepatocyte initiation during continuous administration of diethylnitrosamine and 1,2-sym-dimethylhydrazine

Regulation of ingestive behaviors in the rat by GSK1521498, a novel micro-opioid receptor-selective inverse agonist

Relationships between DNA Adduct Formation and Carcinogenesis

Molecular dosimetry of O4-ethyldeoxythymidine in rats continuously exposed to diethylnitrosamine

Differential repair of O4-alkylthymidine following exposure to methylating and ethylating hepatocarcinogens

Differential repair of O 4 -alkylthymidine following exposure to methylating and ethylating hepatocarcinogens

Novel GSK-3 Inhibitor with Improved Cellular Activity

Macromolecular adducts of ethylene oxide: a literature review and a time-course study on the formation of 7-(2-hydroxyethyl)guanine following exposures of rats by inhalation

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models

Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models: e0145499

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