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A framework for chemical safety assessment incorporating new approach methodologies within REACH

Archives of toxicology, 2022-03, Vol.96 (3), p.743-766

2022

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Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice

PloS one, 2016-10, Vol.11 (10), p.e0164094

2016

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Skin sensitization risk assessment for plant protection products: The applicability of sensitization assessment factors

Regulatory toxicology and pharmacology, 2019-04, Vol.103, p.216-217

2019

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Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity

Archives of toxicology, 2023-08, Vol.97 (8), p.2291-2302

2023

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Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments?

Critical reviews in toxicology, 2020-10, Vol.50 (9), p.740-763

2020

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Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny-part III: how is substance-mediated thyroid hormone imbalance in pregnant/lactating rats or their progeny related to neurodevelopmental effects?

Critical reviews in toxicology, 2022-08, Vol.52 (7), p.546-617

2022

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Hazard identification, classification, and risk assessment of carcinogens: too much or too little? - Report of an ECETOC workshop

Critical reviews in toxicology, 2020-01, Vol.50 (1), p.72-95

2020

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Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments?

Critical reviews in toxicology, 2021-04, Vol.51 (4), p.328-358

2021

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Paraquat pharmacokinetics in primates and extrapolation to humans

Toxicology and applied pharmacology, 2021-04, Vol.417, p.115463, Article 115463

2021

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Integration of paraquat pharmacokinetic data across species using PBPK modelling

Toxicology and applied pharmacology, 2021-04, Vol.417, p.115462, Article 115462

2021

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Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice

Neurotoxicology (Park Forest South), 2013-07, Vol.37, p.1-14

2013

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Dietary administration of paraquat for 13weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice

Regulatory toxicology and pharmacology, 2014-03, Vol.68 (2), p.250-258

2014

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Dietary administration of paraquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice

Regulatory toxicology and pharmacology, 2014-03, Vol.68 (2), p.250

2014

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Dietary administration of diquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice

Regulatory toxicology and pharmacology, 2016-03, Vol.75, p.81-88

2016

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The validation of in vitro methods for skin irritation

Toxicology letters, 2004-04, Vol.149 (1), p.387-390

Botham, Philip A.

2004

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Outcome of the ECVAM skin irritation validation study

Toxicology (Amsterdam), 2007, Vol.231 (2), p.98-99

Botham, Philip A

2007

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ECVAM's Activities in Validating Alternative Tests for Skin Corrosion and Irritation

ATLA. Alternatives to laboratory animals, 2002-12, Vol.30 (2), p.61-67

2002

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Acute systemic toxicity

ILAR journal, 2002, Vol.43 Suppl (Suppl_1), p.S27-S30

Botham, Philip A

2002

Volltextzugriff (PDF)

ECVAM, ECETOC and the EU Chemicals Policy

ATLA. Alternatives to laboratory animals, 2002-12, Vol.30 (2), p.185-187

Botham, Philip A

2002

Volltextzugriff (PDF)

Follow-up to the ECVAM prevalidation study on in vitro tests for acute skin Irritation. ECVAM Skin Irritation Task Force Report 2

Alternatives to laboratory animals, 2002, Vol.30 (1), p.109-129

2002

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Update on the validation and regulatory acceptance of alternative tests for skin corrosion and irritation

Alternatives to laboratory animals, 2004-06, Vol.32 Suppl 1B (1_suppl), p.683-688

2004

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Skin irritation and corrosion

Alternatives to laboratory animals, 2005-07, Vol.33 Suppl 1, p.35

2005

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The international symposium on regulatory testing and animal welfare: recommendations on best scientific practices for acute local skin and eye toxicity testing

ILAR journal, 2002, Vol.43 Suppl, p.S105

2002

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Assessment of the relative skin sensitizing potency of 3 biocides using the murine local lymph node assay

Contact dermatitis, 1991-09, Vol.25 (3), p.172-177

1991

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A framework for chemical safety assessment incorporating new approach methodologies within REACH

Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice

Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - Part IV: the ECETOC and CLE Proposal for a Thyroid Function-Related Neurodevelopmental Toxicity Testing and Assessment Scheme (Thyroid-NDT-TAS)

Skin sensitization risk assessment for plant protection products: The applicability of sensitization assessment factors

Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity

Toward a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part I: which parameters from human studies are most relevant for toxicological assessments?

Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny-part III: how is substance-mediated thyroid hormone imbalance in pregnant/lactating rats or their progeny related to neurodevelopmental effects?

Hazard identification, classification, and risk assessment of carcinogens: too much or too little? - Report of an ECETOC workshop

Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny - part II: how can key events of relevant adverse outcome pathways be addressed in toxicological assessments?

Paraquat pharmacokinetics in primates and extrapolation to humans

Integration of paraquat pharmacokinetic data across species using PBPK modelling

Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice

Dietary administration of paraquat for 13weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice

Dietary administration of paraquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice

Dietary administration of diquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice

The validation of in vitro methods for skin irritation

Outcome of the ECVAM skin irritation validation study

ECVAM's Activities in Validating Alternative Tests for Skin Corrosion and Irritation

Acute systemic toxicity

ECVAM, ECETOC and the EU Chemicals Policy

Follow-up to the ECVAM prevalidation study on in vitro tests for acute skin Irritation. ECVAM Skin Irritation Task Force Report 2

Update on the validation and regulatory acceptance of alternative tests for skin corrosion and irritation

Skin irritation and corrosion

The international symposium on regulatory testing and animal welfare: recommendations on best scientific practices for acute local skin and eye toxicity testing

Assessment of the relative skin sensitizing potency of 3 biocides using the murine local lymph node assay

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