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Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery

Antimicrobial agents and chemotherapy, 2016-11, Vol.60 (11), p.6748-6757

2016

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Meropenem-Clavulanic Acid Shows Activity against Mycobacterium tuberculosis In Vivo

Antimicrobial Agents and Chemotherapy, 2012-06, Vol.56 (6), p.3384-3387

2012

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PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

Science (American Association for the Advancement of Science), 2008-11, Vol.322 (5906), p.1392-1395

2008

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Mutations in gidB Confer Low-Level Streptomycin Resistance in Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy, 2011-06, Vol.55 (6), p.2515-2522

2011

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Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches

Journal of medicinal chemistry, 2019-08, Vol.62 (15), p.7210-7232

2019

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The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance

Journal of Bacteriology, 2010-03, Vol.192 (5), p.1279-1291

2010

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Proteasomal Protein Degradation in Mycobacteria Is Dependent upon a Prokaryotic Ubiquitin-like Protein

The Journal of biological chemistry, 2009-01, Vol.284 (5), p.3069-3075

2009

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1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

Molecules (Basel, Switzerland), 2020-06, Vol.25 (12), p.2805

2020

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Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis

ACS infectious diseases, 2016-12, Vol.2 (12), p.958-968

2016

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Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis

PloS one, 2013-09, Vol.8 (9), p.e75245-e75245

2013

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Susceptibility of Mycobacterium tuberculosis Cytochrome bd Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome c

Antimicrobial agents and chemotherapy, 2017-10, Vol.61 (10)

2017

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Structure–Activity Relationships of Pyrazolo[1,5‑a]pyrimidin-7(4H)‑ones as Antitubercular Agents

ACS infectious diseases, 2021-02, Vol.7 (2), p.479-492

2021

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Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis

Molecular microbiology, 2012-10, Vol.86 (2), p.367-381

2012

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Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure–Activity As Potential Antituberculosis Agents

Journal of medicinal chemistry, 2018-06, Vol.61 (11), p.4739-4756

2018

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Editorial: Drug-resistant Mycobacterium tuberculosis

Frontiers in cellular and infection microbiology, 2023-05, Vol.13, p.1215294-1215294

2023

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Tuberculosis - metabolism and respiration in the absence of growth

Nature reviews. Microbiology, 2005-01, Vol.3 (1), p.70-80

2005

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Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents

European journal of medicinal chemistry, 2020-11, Vol.206, p.112659-112659, Article 112659

2020

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genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (47), p.19095-19100

2013

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Discovery and Structure–Activity-Relationship Study of N‑Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β‑d‑ribose 2′-Oxidase

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.9952-9965

2018

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1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis

Journal of medicinal chemistry, 2021-09, Vol.64 (17), p.12790-12807

2021

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Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode

Journal of medicinal chemistry, 2019-12, Vol.62 (23), p.10586-10604

2019

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Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

Nucleic acids research, 2020-08, Vol.48 (14), p.8099

2020

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Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis

ACS medicinal chemistry letters, 2018-04, Vol.9 (4), p.386-391

2018

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Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure–Activity As Potential Antituberculosis Agents

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.18233-18234

2021

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Correction for Singh et al., “The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance”

Journal of bacteriology, 2020-11, Vol.202 (24)

2020

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Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery

Meropenem-Clavulanic Acid Shows Activity against Mycobacterium tuberculosis In Vivo

PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

Mutations in gidB Confer Low-Level Streptomycin Resistance in Mycobacterium tuberculosis

Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches

The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance

Proteasomal Protein Degradation in Mycobacteria Is Dependent upon a Prokaryotic Ubiquitin-like Protein

1-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors

Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis

Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis

Susceptibility of Mycobacterium tuberculosis Cytochrome bd Oxidase Mutants to Compounds Targeting the Terminal Respiratory Oxidase, Cytochrome c

Structure–Activity Relationships of Pyrazolo[1,5‑a]pyrimidin-7(4H)‑ones as Antitubercular Agents

Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis

Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure–Activity As Potential Antituberculosis Agents

Editorial: Drug-resistant Mycobacterium tuberculosis

Tuberculosis - metabolism and respiration in the absence of growth

Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents

genetic strategy to identify targets for the development of drugs that prevent bacterial persistence

Discovery and Structure–Activity-Relationship Study of N‑Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β‑d‑ribose 2′-Oxidase

1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis

Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis

Expanding Benzoxazole-Based Inosine 5′-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure–Activity As Potential Antituberculosis Agents

Correction for Singh et al., “The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance”

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