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Toxicokinetic Triage for Environmental Chemicals

Toxicological sciences, 2015-09, Vol.147 (1), p.55-67

2015

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Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling

European journal of pharmaceutical sciences, 2014-12, Vol.65, p.156-166

2014

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Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide

Molecular therapy. Nucleic acids, 2019-09, Vol.17, p.601-614

2019

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P816: PHARMACODYNAMIC ACTIVITY OF GEN3014 (HEXABODY‐CD38) IN PATIENTS WITH MULTIPLE MYELOMA SUPPORTS ENHANCED COMPLEMENT DEPENDENT CYTOTOXICITY OF GEN3014 COMPARED TO DARATUMUMAB

HemaSphere, 2023-08, Vol.7 (S3), p.e008261b-n/a

2023

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Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context

Reproductive toxicology (Elmsford, N.Y.), 2015-08, Vol.55, p.11-19

2015

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Availability of Polychlorinated Biphenyls (PCBs) and Lindane for Uptake by Intestinal Caco-2 Cells

Environmental health perspectives, 2001-07, Vol.109 (7), p.731-737

2001

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Interpreting in vitro developmental toxicity test battery results: The consideration of toxicokinetics

Reproductive toxicology (Elmsford, N.Y.), 2015-08, Vol.55, p.73-80

2015

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An asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies

Journal of pharmacokinetics and pharmacodynamics, 2024-06

2024

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Preliminary Dose-Escalation Results from a Phase 1/2 Study of GEN3014 (HexaBody®-CD38) in Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM)

Blood, 2022-11, Vol.140 (Supplement 1), p.7320-7321

2022

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An improved model to predict physiologically based model parameters and their inter-individual variability from anthropometry

Critical reviews in toxicology, 2012-10, Vol.42 (9), p.751-767

2012

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Human glycemic response curves after intake of carbohydrate foods are accurately predicted by combining in vitro gastrointestinal digestion with in silico kinetic modeling

Clinical Nutrition Experimental, 2018-02, Vol.17 (C), p.8-22

2018

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Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

Archives of toxicology, 2015-07, Vol.89 (7), p.1135-1148

2015

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Preclinical Anti-Tumor Activity of Hexabody-CD38 in Patient-Derived B Cell Lymphoma and Acute Myeloid Leukemia Xenograft Models

Blood, 2020-11, Vol.136 (Supplement 1), p.19-20

2020

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To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics

Clinical pharmacokinetics, 2016-01, Vol.55 (1), p.1-15

2016

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Next Generation Exon 51 Skipping Antisense Oligonucleotides for Duchenne Muscular Dystrophy

Nucleic acid therapeutics, 2023-06, Vol.33 (3), p.193

2023

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Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay

Archives of toxicology, 2017-01, Vol.91 (1), p.365-391

2017

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Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity

EBioMedicine, 2023-07, Vol.93, p.104663-104663, Article 104663

2023

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Extrapolation of toxic concentrations in in vitro assays by a high throughput PBPK model

Toxicology letters, 2012-06, Vol.211, p.S63-S63

2012

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An integrated probabilistic framework for cumulative risk assessment of common mechanism chemicals in food: An example with organophosphorus pesticides

Regulatory toxicology and pharmacology, 2009-07, Vol.54 (2), p.124-133

2009

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Human risk assessment—Choosing the appropriate dose metric by PBPK-modeling

Toxicology letters, 2012-06, Vol.211, p.S127-S127

2012

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Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26Al Microtracer Approach

Clinical and translational science, 2018-11, Vol.11 (6), p.573-581

2018

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Integrated testing strategy for reproductive toxicity

Reproductive toxicology (Elmsford, N.Y.), 2012-09, Vol.34 (2), p.172-172

2012

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Probabilistic cumulative risk assessment of anti-androgenic pesticides in food

Food and chemical toxicology, 2009-12, Vol.47 (12), p.2951-2962

2009

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Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26 Al Microtracer Approach

Clinical and translational science, 2018-11, Vol.11 (6), p.573-581

2018

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Toxicokinetic Triage for Environmental Chemicals

Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling

Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide

P816: PHARMACODYNAMIC ACTIVITY OF GEN3014 (HEXABODY‐CD38) IN PATIENTS WITH MULTIPLE MYELOMA SUPPORTS ENHANCED COMPLEMENT DEPENDENT CYTOTOXICITY OF GEN3014 COMPARED TO DARATUMUMAB

Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context

Availability of Polychlorinated Biphenyls (PCBs) and Lindane for Uptake by Intestinal Caco-2 Cells

Interpreting in vitro developmental toxicity test battery results: The consideration of toxicokinetics

An asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies

Preliminary Dose-Escalation Results from a Phase 1/2 Study of GEN3014 (HexaBody®-CD38) in Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM)

An improved model to predict physiologically based model parameters and their inter-individual variability from anthropometry

Human glycemic response curves after intake of carbohydrate foods are accurately predicted by combining in vitro gastrointestinal digestion with in silico kinetic modeling

Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling

Preclinical Anti-Tumor Activity of Hexabody-CD38 in Patient-Derived B Cell Lymphoma and Acute Myeloid Leukemia Xenograft Models

To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics

Next Generation Exon 51 Skipping Antisense Oligonucleotides for Duchenne Muscular Dystrophy

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay

Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activityResearch in context

Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity

Extrapolation of toxic concentrations in in vitro assays by a high throughput PBPK model

An integrated probabilistic framework for cumulative risk assessment of common mechanism chemicals in food: An example with organophosphorus pesticides

Human risk assessment—Choosing the appropriate dose metric by PBPK-modeling

Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26Al Microtracer Approach

Integrated testing strategy for reproductive toxicity

Probabilistic cumulative risk assessment of anti-androgenic pesticides in food

Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26 Al Microtracer Approach

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