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Physiologically based pharmacokinetic model for ethyl tertiary‐butyl ether and tertiary‐butyl alcohol in rats: Contribution of binding to α2u–globulin in male rats and high‐exposure nonlinear kinetics to toxicity and cancer outcomes

Journal of applied toxicology, 2017-05, Vol.37 (5), p.621-640

2017

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RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days

Data in brief, 2021-10, Vol.38, p.107420-107420, Article 107420

2021

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Assessment of the applicability of the threshold of toxicological concern for per- and polyfluoroalkyl substances

Regulatory toxicology and pharmacology, 2022-08, Vol.133, p.105190-105190, Article 105190

2022

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Oral toxicity evaluation of cannabidiol

Food and chemical toxicology, 2023-06, Vol.176, p.113778-113778, Article 113778

2023

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Assessment of the genotoxicity of tert‐butyl alcohol in an in vivo thyroid comet assay

Environmental and molecular mutagenesis, 2024-03, Vol.65 (3-4), p.129-136

2024

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Comparison of threshold of toxicological concern (TTC) values to oral reference dose (RfD) values

Regulatory toxicology and pharmacology, 2020-06, Vol.113, p.104651, Article 104651

2020

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Kinetics of Genistein and Its Conjugated Metabolites in Pregnant Sprague-Dawley Rats Following Single and Repeated Genistein Administration

Toxicological sciences, 2006-03, Vol.90 (1), p.230-240

2006

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A Framework for Systematic Evaluation and Quantitative Integration of Mechanistic Data in Assessments of Potential Human Carcinogens

Toxicological sciences, 2019-02, Vol.167 (2), p.322-335

2019

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Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame

Food and chemical toxicology, 2023-02, Vol.172, p.113549, Article 113549

2023

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Kinetics of selected di- n -butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats

Toxicology (Amsterdam), 2009-01, Vol.255 (1), p.80-90

2009

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Adverse outcome pathway (AOP): α2u-globulin nephropathy and kidney tumors in male rats

Critical reviews in toxicology, 2022-05, Vol.52 (5), p.345-357

2022

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A systematic approach to evaluate plausible modes of actions for mouse lung tumors in mice exposed to 4-methylimidozole

Regulatory toxicology and pharmacology, 2021-08, Vol.124, p.104977, Article 104977

2021

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An Adverse Outcome Pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events

Regulatory toxicology and pharmacology, 2018-07, Vol.96, p.30-40

2018

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Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to alpha 2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes

Journal of applied toxicology, 2017-05, Vol.37 (5), p.621-640

2017

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Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents

Regulatory toxicology and pharmacology, 2007-03, Vol.47 (2), p.156-165

2007

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Nondetectable or minimal detectable residue levels of N-(n-butyl) thiophosphoric triamide in bovine tissues and milk from a 28-d NBPT dosing study

Translational animal science, 2019-07, Vol.3 (4), p.1606-1616

2019

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Physiologically Based Pharmacokinetic Model of Methyl Tertiary Butyl Ether and Tertiary Butyl Alcohol Dosimetry in Male Rats Based on Binding to α2u-Globulin

Toxicological sciences, 2009-06, Vol.109 (2), p.321-335

2009

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Physiologically based pharmacokinetic rat model for methyl tertiary -butyl ether; comparison of selected dose metrics following various MTBE exposure scenarios used for toxicity and carcinogenicity evaluation

Toxicology (Amsterdam), 2010-09, Vol.275 (1), p.79-91

2010

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Tissue Exposures to Free and Glucuronidated Monobutylyphthalate in the Pregnant and Fetal Rat following Exposure to Di-n-butylphthalate: Evaluation with a PBPK Model

Toxicological sciences, 2008-06, Vol.103 (2), p.241-259

2008

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Lessons learned, challenges, and opportunities: the U.S. Endocrine Disruptor Screening Program

ALTEX, alternatives to animal experimentation, 2014, Vol.31 (1), p.63-78

2014

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Bayesian Estimation of Pharmacokinetic and Pharmacodynamic Parameters in a Mode-of-Action-Based Cancer Risk Assessment for Chloroform

Risk analysis, 2007-12, Vol.27 (6), p.1535-1551

2007

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Pharmacokinetics of monobutylphthalate, the active metabolite of di- n-butylphthalate, in pregnant rats

Toxicology letters, 2005-11, Vol.159 (2), p.144-153

2005

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Male Mice Deficient in Microsomal Epoxide Hydrolase Are Not Susceptible to Benzene-Induced Toxicity

Toxicological sciences, 2003-04, Vol.72 (2), p.201-209

2003

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Physiologically-Based Pharmacokinetic Modeling of Genistein in Rats, Part I: Model Development

Risk analysis, 2006-04, Vol.26 (2), p.483-500

2006

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A Physiologically Based Pharmacokinetic Model for Methyl tert-Butyl Ether in Humans: Implementing Sensitivity and Variability Analyses

Toxicological sciences, 2001-08, Vol.62 (2), p.191-204

2001

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Physiologically based pharmacokinetic model for ethyl tertiary‐butyl ether and tertiary‐butyl alcohol in rats: Contribution of binding to α2u–globulin in male rats and high‐exposure nonlinear kinetics to toxicity and cancer outcomes

RNA-sequencing (transcriptomic) data collected in liver and lung of male and female B6C3F1 mice exposed to various dose levels of 4-methylimidazole for 2, 5, or 28 days

Assessment of the applicability of the threshold of toxicological concern for per- and polyfluoroalkyl substances

Oral toxicity evaluation of cannabidiol

Assessment of the genotoxicity of tert‐butyl alcohol in an in vivo thyroid comet assay

Comparison of threshold of toxicological concern (TTC) values to oral reference dose (RfD) values

Kinetics of Genistein and Its Conjugated Metabolites in Pregnant Sprague-Dawley Rats Following Single and Repeated Genistein Administration

A Framework for Systematic Evaluation and Quantitative Integration of Mechanistic Data in Assessments of Potential Human Carcinogens

Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame

Kinetics of selected di- n -butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats

Adverse outcome pathway (AOP): α2u-globulin nephropathy and kidney tumors in male rats

A systematic approach to evaluate plausible modes of actions for mouse lung tumors in mice exposed to 4-methylimidozole

An Adverse Outcome Pathway (AOP) for forestomach tumors induced by non-genotoxic initiating events

Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to alpha 2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes

Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents

Nondetectable or minimal detectable residue levels of N-(n-butyl) thiophosphoric triamide in bovine tissues and milk from a 28-d NBPT dosing study

Physiologically Based Pharmacokinetic Model of Methyl Tertiary Butyl Ether and Tertiary Butyl Alcohol Dosimetry in Male Rats Based on Binding to α2u-Globulin

Physiologically based pharmacokinetic rat model for methyl tertiary -butyl ether; comparison of selected dose metrics following various MTBE exposure scenarios used for toxicity and carcinogenicity evaluation

Tissue Exposures to Free and Glucuronidated Monobutylyphthalate in the Pregnant and Fetal Rat following Exposure to Di-n-butylphthalate: Evaluation with a PBPK Model

Lessons learned, challenges, and opportunities: the U.S. Endocrine Disruptor Screening Program

Bayesian Estimation of Pharmacokinetic and Pharmacodynamic Parameters in a Mode-of-Action-Based Cancer Risk Assessment for Chloroform

Pharmacokinetics of monobutylphthalate, the active metabolite of di- n-butylphthalate, in pregnant rats

Male Mice Deficient in Microsomal Epoxide Hydrolase Are Not Susceptible to Benzene-Induced Toxicity

Physiologically-Based Pharmacokinetic Modeling of Genistein in Rats, Part I: Model Development

A Physiologically Based Pharmacokinetic Model for Methyl tert-Butyl Ether in Humans: Implementing Sensitivity and Variability Analyses

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